Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-β signaling in mesangial cells

Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-β signaling in mesangial cells. Lipid abnormalities and oxidative stress may be involved in the development of glomerulosclerosis. Plasminogen activator inhibitor-1 (PAI-1) is a component of extracellular matrix (ECM) and...

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Veröffentlicht in:	Kidney international 2005-05, Vol.67 (5), p.1743-1752
Hauptverfasser:	Song, Chi Young, Kim, Bong Cho, Hong, Hye Kyoung, Lee, Hyun Soon
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites - genetics Biological and medical sciences CAGA sequences Cells, Cultured DNA - genetics DNA - metabolism DNA-Binding Proteins - metabolism extracellular matrix Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism glomerulosclerosis Humans lipids Lipoproteins, LDL - pharmacology Medical sciences Nephrology. Urinary tract diseases oxidative stress Plasminogen Activator Inhibitor 1 - genetics Promoter Regions, Genetic RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Smad3 Protein TGF-β Trans-Activators - metabolism Transcriptional Activation - drug effects Transfection Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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