A Systematic Study of C-Glucoside Trisphosphates as myo-Inositol Trisphosphate Receptor Ligands. Synthesis of β-C-Glucoside Trisphosphates Based on the Conformational Restriction Strategy

β-C-Glucoside trisphosphates having a C2 side chain (3,7-anhydro-2-deoxy-d-glycero-d-gulo-octitol 1,5,6-trisphosphate, 11) and a C3 side chain (4,8-anhydro-2,3-dideoxy-d-glycero-d-gulo-nonanitol 1,6,7-trisphosphate, 12) were designed as structurally simplified analogues of a potent d-myo-inositol 1,...

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Veröffentlicht in:	Journal of medicinal chemistry 2006-03, Vol.49 (6), p.1900-1909
Hauptverfasser:	Terauchi, Masaru, Abe, Hiroshi, Tovey, Stephen C, Dedos, Skarlatos G, Taylor, Colin W, Paul, Michael, Trusselle, Melanie, Potter, Barry V. L, Matsuda, Akira, Shuto, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Calcium - metabolism Calcium Channels - metabolism Cell Line Chickens Cyclization Glucosides - chemical synthesis Glucosides - chemistry Glucosides - pharmacology Inositol 1,4,5-Trisphosphate Receptors Ligands Medical sciences Miscellaneous Models, Molecular Molecular Conformation Organophosphates - chemical synthesis Organophosphates - chemistry Organophosphates - pharmacology Oxidation-Reduction Pharmacology. Drug treatments Rats Receptors, Cytoplasmic and Nuclear - metabolism Recombinant Proteins - metabolism Silanes - chemistry Structure-Activity Relationship
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