Exogenous carbohydrate oxidation during ultraendurance exercise
Human Performance Laboratory, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom Submitted 7 September 2004 ; accepted in final form 29 November 2005 The purposes of this study were: 1 ) to obtain a measure of exogenous carbohydrate (CHO Exo ) oxid...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2006-04, Vol.100 (4), p.1134-1141 |
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| creator | Jeukendrup, Asker E Moseley, Luke Mainwaring, Gareth I Samuels, Spencer Perry, Samuel Mann, Christopher H |
| description | Human Performance Laboratory, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Submitted 7 September 2004
; accepted in final form 29 November 2005
The purposes of this study were: 1 ) to obtain a measure of exogenous carbohydrate (CHO Exo ) oxidation and plasma glucose kinetics during 5 h of exercise; and 2 ) to compare CHO Exo following the ingestion of a glucose solution (Glu) or a glucose + fructose solution (2:1 ratio, Glu+Fru) during ultraendurance exercise. Eight well-trained subjects exercised three times for 5 h at 58% maximum O 2 consumption while ingesting either Glu or Glu+Fru (both delivering 1.5 g/min CHO) or water. The CHO used had a naturally high 13 C enrichment, and five subjects received a primed continuous intravenous [6,6- 2 H 2 ]glucose infusion. CHO Exo rates following the ingestion of Glu leveled off after 120 min and peaked at 1.24 ± 0.04 g/min. The ingestion of Glu+Fru resulted in a significantly higher peak rate of CHO Exo (1.40 ± 0.08 g/min), a faster rate of increase in CHO Exo , and an increase in the percentage of CHO Exo oxidized (6577%). However, the rate of appearance and disappearance of Glu continued to increase during exercise, with no differences between trials. These data suggest an important role for gluconeogenesis during the later stages of exercise. Following the ingestion of Glu+Fru, cadence (rpm) was maintained, and the perception of stomach fullness was reduced relative to Glu. The ingestion of Glu+Fru increases CHO Exo compared with the ingestion of Glu alone, potentially through the oxidation of CHO Exo in the liver or through the conversion to, and oxidation of, lactate.
stable isotopes; carbohydrate absorption; glucose; fructose; metabolism
Address for reprint requests and other correspondence: A. Jeukendrup, School of Sport and Exercise Sciences, Univ. of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom (e-mail: A.E.Jeukendrup{at}bham.ac.uk ) |
| doi_str_mv | 10.1152/japplphysiol.00981.2004 |
| format | Article |
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Submitted 7 September 2004
; accepted in final form 29 November 2005
The purposes of this study were: 1 ) to obtain a measure of exogenous carbohydrate (CHO Exo ) oxidation and plasma glucose kinetics during 5 h of exercise; and 2 ) to compare CHO Exo following the ingestion of a glucose solution (Glu) or a glucose + fructose solution (2:1 ratio, Glu+Fru) during ultraendurance exercise. Eight well-trained subjects exercised three times for 5 h at 58% maximum O 2 consumption while ingesting either Glu or Glu+Fru (both delivering 1.5 g/min CHO) or water. The CHO used had a naturally high 13 C enrichment, and five subjects received a primed continuous intravenous [6,6- 2 H 2 ]glucose infusion. CHO Exo rates following the ingestion of Glu leveled off after 120 min and peaked at 1.24 ± 0.04 g/min. The ingestion of Glu+Fru resulted in a significantly higher peak rate of CHO Exo (1.40 ± 0.08 g/min), a faster rate of increase in CHO Exo , and an increase in the percentage of CHO Exo oxidized (6577%). However, the rate of appearance and disappearance of Glu continued to increase during exercise, with no differences between trials. These data suggest an important role for gluconeogenesis during the later stages of exercise. Following the ingestion of Glu+Fru, cadence (rpm) was maintained, and the perception of stomach fullness was reduced relative to Glu. The ingestion of Glu+Fru increases CHO Exo compared with the ingestion of Glu alone, potentially through the oxidation of CHO Exo in the liver or through the conversion to, and oxidation of, lactate.
stable isotopes; carbohydrate absorption; glucose; fructose; metabolism
Address for reprint requests and other correspondence: A. Jeukendrup, School of Sport and Exercise Sciences, Univ. of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom (e-mail: A.E.Jeukendrup{at}bham.ac.uk )</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00981.2004</identifier><identifier>PMID: 16322366</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Administration, Oral ; Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Carbohydrate Metabolism ; Carbohydrates ; Exercise ; Exercise - physiology ; Fructose - administration & dosage ; Fructose - metabolism ; Fundamental and applied biological sciences. Psychology ; Gluconeogenesis ; Glucose ; Glucose - administration & dosage ; Glucose - metabolism ; Humans ; Kinetics ; Liver - metabolism ; Male ; Oxidation ; Oxidation-Reduction ; Physical Endurance - physiology ; Plasma</subject><ispartof>Journal of applied physiology (1985), 2006-04, Vol.100 (4), p.1134-1141</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright American Physiological Society Apr 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-aee6515e620a28b7b5116226251ff864c7c045f9838fe07f2ec703c3c230e1e03</citedby><cites>FETCH-LOGICAL-c528t-aee6515e620a28b7b5116226251ff864c7c045f9838fe07f2ec703c3c230e1e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17665961$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16322366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeukendrup, Asker E</creatorcontrib><creatorcontrib>Moseley, Luke</creatorcontrib><creatorcontrib>Mainwaring, Gareth I</creatorcontrib><creatorcontrib>Samuels, Spencer</creatorcontrib><creatorcontrib>Perry, Samuel</creatorcontrib><creatorcontrib>Mann, Christopher H</creatorcontrib><title>Exogenous carbohydrate oxidation during ultraendurance exercise</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Human Performance Laboratory, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Submitted 7 September 2004
; accepted in final form 29 November 2005
The purposes of this study were: 1 ) to obtain a measure of exogenous carbohydrate (CHO Exo ) oxidation and plasma glucose kinetics during 5 h of exercise; and 2 ) to compare CHO Exo following the ingestion of a glucose solution (Glu) or a glucose + fructose solution (2:1 ratio, Glu+Fru) during ultraendurance exercise. Eight well-trained subjects exercised three times for 5 h at 58% maximum O 2 consumption while ingesting either Glu or Glu+Fru (both delivering 1.5 g/min CHO) or water. The CHO used had a naturally high 13 C enrichment, and five subjects received a primed continuous intravenous [6,6- 2 H 2 ]glucose infusion. CHO Exo rates following the ingestion of Glu leveled off after 120 min and peaked at 1.24 ± 0.04 g/min. The ingestion of Glu+Fru resulted in a significantly higher peak rate of CHO Exo (1.40 ± 0.08 g/min), a faster rate of increase in CHO Exo , and an increase in the percentage of CHO Exo oxidized (6577%). However, the rate of appearance and disappearance of Glu continued to increase during exercise, with no differences between trials. These data suggest an important role for gluconeogenesis during the later stages of exercise. Following the ingestion of Glu+Fru, cadence (rpm) was maintained, and the perception of stomach fullness was reduced relative to Glu. The ingestion of Glu+Fru increases CHO Exo compared with the ingestion of Glu alone, potentially through the oxidation of CHO Exo in the liver or through the conversion to, and oxidation of, lactate.
stable isotopes; carbohydrate absorption; glucose; fructose; metabolism
Address for reprint requests and other correspondence: A. Jeukendrup, School of Sport and Exercise Sciences, Univ. of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom (e-mail: A.E.Jeukendrup{at}bham.ac.uk )</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Carbohydrate Metabolism</subject><subject>Carbohydrates</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Fructose - administration & dosage</subject><subject>Fructose - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gluconeogenesis</subject><subject>Glucose</subject><subject>Glucose - administration & dosage</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Physical Endurance - physiology</subject><subject>Plasma</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFr2zAUhcVYWbNuf2Ezgw324FRXsiTnaYzSboNCX9pnocjXiYJieZJNk38_eTFkDMaehNB37j06h5D3QJcAgl3vTN_7fntMLvglpasalozS6gVZ5FdWgqTwkixqJWipRK0uyeuUdpRCVQl4RS5Bcsa4lAvy5fYQNtiFMRXWxHXYHptoBizCwTVmcKErmjG6blOMfogGu3wzncUCDxitS_iGXLTGJ3w7n1fk6e728eZ7ef_w7cfN1_vSClYPpUGUAgRKRg2r12otACRjkglo21pWVllaiXZV87pFqlqGVlFuuWWcIiDlV-TTaW4fw88R06D3Lln03nSYzWuplBAKqv-CoIBTWasMfvgL3IUxdvkTmjGWE1RslSF1gmwMKUVsdR_d3sSjBqqnJvSfTejfTeipiax8N48f13tszro5-gx8nAGTrPHtlKtLZ05JKVYSMvf5xG3dZvvsIup5W9gcp-3ZCdVVNsOnpeLf7N3o_SMehkl01ui-afkvvg62OA</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Jeukendrup, Asker E</creator><creator>Moseley, Luke</creator><creator>Mainwaring, Gareth I</creator><creator>Samuels, Spencer</creator><creator>Perry, Samuel</creator><creator>Mann, Christopher H</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Exogenous carbohydrate oxidation during ultraendurance exercise</title><author>Jeukendrup, Asker E ; Moseley, Luke ; Mainwaring, Gareth I ; Samuels, Spencer ; Perry, Samuel ; Mann, Christopher H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-aee6515e620a28b7b5116226251ff864c7c045f9838fe07f2ec703c3c230e1e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Carbohydrate Metabolism</topic><topic>Carbohydrates</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Fructose - administration & dosage</topic><topic>Fructose - metabolism</topic><topic>Fundamental and applied biological sciences. 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Submitted 7 September 2004
; accepted in final form 29 November 2005
The purposes of this study were: 1 ) to obtain a measure of exogenous carbohydrate (CHO Exo ) oxidation and plasma glucose kinetics during 5 h of exercise; and 2 ) to compare CHO Exo following the ingestion of a glucose solution (Glu) or a glucose + fructose solution (2:1 ratio, Glu+Fru) during ultraendurance exercise. Eight well-trained subjects exercised three times for 5 h at 58% maximum O 2 consumption while ingesting either Glu or Glu+Fru (both delivering 1.5 g/min CHO) or water. The CHO used had a naturally high 13 C enrichment, and five subjects received a primed continuous intravenous [6,6- 2 H 2 ]glucose infusion. CHO Exo rates following the ingestion of Glu leveled off after 120 min and peaked at 1.24 ± 0.04 g/min. The ingestion of Glu+Fru resulted in a significantly higher peak rate of CHO Exo (1.40 ± 0.08 g/min), a faster rate of increase in CHO Exo , and an increase in the percentage of CHO Exo oxidized (6577%). However, the rate of appearance and disappearance of Glu continued to increase during exercise, with no differences between trials. These data suggest an important role for gluconeogenesis during the later stages of exercise. Following the ingestion of Glu+Fru, cadence (rpm) was maintained, and the perception of stomach fullness was reduced relative to Glu. The ingestion of Glu+Fru increases CHO Exo compared with the ingestion of Glu alone, potentially through the oxidation of CHO Exo in the liver or through the conversion to, and oxidation of, lactate.
stable isotopes; carbohydrate absorption; glucose; fructose; metabolism
Address for reprint requests and other correspondence: A. Jeukendrup, School of Sport and Exercise Sciences, Univ. of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom (e-mail: A.E.Jeukendrup{at}bham.ac.uk )</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>16322366</pmid><doi>10.1152/japplphysiol.00981.2004</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Administration, Oral Adult Biological and medical sciences Blood Glucose - metabolism Carbohydrate Metabolism Carbohydrates Exercise Exercise - physiology Fructose - administration & dosage Fructose - metabolism Fundamental and applied biological sciences. Psychology Gluconeogenesis Glucose Glucose - administration & dosage Glucose - metabolism Humans Kinetics Liver - metabolism Male Oxidation Oxidation-Reduction Physical Endurance - physiology Plasma |
| title | Exogenous carbohydrate oxidation during ultraendurance exercise |
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