Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant

One third of acute myeloid leukemias (AMLs) are characterized by the aberrant cytoplasmic localization of nucleophosmin (NPM) due to mutations within its putative nucleolar localization signal. NPM mutations are mutually exclusive with major AML-associated chromosome rearrangements and are frequentl...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-03, Vol.66 (6), p.3044-3050
Hauptverfasser:	COLOMBO, Emanuela, MARTINELLI, Paola, GIUSEPPE PELICCI, Pier, ZAMPONI, Raffaella, SHING, Danielle C, BONETTI, Paola, LUZI, Lucilla, VOLORIO, Sara, BERNARD, Loris, PRUNERI, Giancarlo, ALCALAY, Myriam
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antineoplastic agents Base Sequence Biological and medical sciences Cell Nucleus - metabolism Cloning, Molecular Cytoplasm - metabolism DNA, Complementary - genetics Hematologic and hematopoietic diseases Humans Leukemia, Myeloid - genetics Leukemia, Myeloid - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mice Molecular Sequence Data Mutation NIH 3T3 Cells Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Nuclear Proteins - metabolism Pharmacology. Drug treatments Plasmids - genetics Transfection Tumor Suppressor Protein p14ARF - genetics Tumor Suppressor Protein p14ARF - metabolism Tumors
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