The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats

The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats. Renal ischemia/reperfusion (I/R) is a complex neutrophil-mediated syndrome. Adenosine-triphosphate (ATP)-sensitive potassium (KATP) channels are involved in neutrophil migration in vivo. In...

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Veröffentlicht in:	Kidney international 2005-05, Vol.67 (5), p.1785-1796
Hauptverfasser:	Pompermayer, Kenia, Souza, Danielle G., Lara, Giovanna G., Silveira, Kátia D., Cassali, Geovanni D., Andrade, Anderson A., Bonjardim, Cláudio A., Passaglio, Kátia T., Assreuy, Jamil, Cunha, Fernando Q., Vieira, Maria Aparecida R., Teixeira, Mauro M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Biological and medical sciences cytokines Cytokines - metabolism Diazoxide - pharmacology Disease Models, Animal glibenclamide Glyburide - pharmacology inflammation Interleukin-10 - metabolism ischemia and reperfusion kidney Kidney - blood supply Kidney - drug effects Kidney - injuries Kidney - metabolism Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure neutrophils Neutrophils - drug effects Neutrophils - metabolism NF-kappa B - metabolism Potassium Channel Blockers - pharmacology Potassium Channels - metabolism Rats Rats, Wistar Renovascular diseases Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control Tumor Necrosis Factor-alpha - metabolism
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