Is endogenous d‐serine in the rostral anterior cingulate cortex necessary for pain‐related negative affect?
Functional activation of NMDA receptors requires co‐activation of glutamate‐ and glycine‐binding sites. d‐serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin‐induced conditioned place avoidance (F‐CPA) behavioral model and who...
Gespeichert in:
| Veröffentlicht in: | Journal of neurochemistry 2006-03, Vol.96 (6), p.1636-1647 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1647 |
|---|---|
| container_issue | 6 |
| container_start_page | 1636 |
| container_title | Journal of neurochemistry |
| container_volume | 96 |
| creator | Ren, Wen‐Hua Guo, Ji‐Dong Cao, Hong Wang, Hua Wang, Pei‐Fen Sha, Hong Ji, Ru‐Rong Zhao, Zhi‐Qi Zhang, Yu‐Qiu |
| description | Functional activation of NMDA receptors requires co‐activation of glutamate‐ and glycine‐binding sites. d‐serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin‐induced conditioned place avoidance (F‐CPA) behavioral model and whole‐cell patch‐clamp recording in rostral anterior cingulate cortex (rACC) slices, we examined the effects of d‐amino acid oxidase (DAAO), an endogenous d‐serine‐degrading enzyme, and 7‐chlorokynurenate (7Cl‐KYNA), an antagonist of the glycine site of NMDA receptors, on pain‐related aversion. Degradation of endogenous d‐serine with DAAO, or selective blockade of the glycine site of NMDA receptors by 7Cl‐KYNA, effectively inhibited NMDA‐evoked currents in rACC slices. Intra‐rACC injection of DAAO (0.1 U) and 7Cl‐KYNA (2 and 0.2 mm, 0.6 µL per side) 20 min before F‐CPA conditioning greatly attenuated F‐CPA scores, but did not affect formalin‐induced acute nociceptive behaviors and electric foot shock‐induced conditioned place avoidance. This study reveals for the first time that endogenous d‐serine plays a critical role in pain‐related aversion by activating the glycine site of NMDA receptors in the rACC. Furthermore, these results extend our hypothesis that activation of NMDA receptors in the rACC is necessary for the acquisition of specific pain‐related negative emotion. Thus a new and promising strategy for the prevention of chronic pain‐induced emotional disturbance might be raised. |
| doi_str_mv | 10.1111/j.1471-4159.2006.03677.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67754978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67754978</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5447-f914ad2ff598606715ea0c22e5e06551a86e5bfcf3f550be2a372959d9855c7d3</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhi3Uii4tr4B8obeEsRPbyQEhtCpQVJULPVteZ7x4lXUWO9tubzwCz8iT1GFX7bH1ZSzPN-OZ_yeEMihZPh9WJasVK2om2pIDyBIqqVS5e0Vmj4kjMgPgvKig5ifkTUorACZryV6TkxyVhAZmZLhMFEM3LDEM20S7f3_-Jow-IPWBjr-QxiGN0fTUhDG_D5FaH5bb3oxI7RBH3NGAFlMy8Z66nN4YH3KTiBPS5eTSjP4WqXEO7fjpjBw70yd8e4in5ObLxc_5t-Lqx9fL-eerwoq6VoVrWW067pxoGwlSMYEGLOcoEKQQzDQSxcJZVzkhYIHcVIq3ou3aRgiruuqUnO_7buLwe4tp1GufLPa9CZgX1VkuUbeqeRZkiinRMpXBZg_aLEmK6PQm-nVeWzPQkyt6pSfx9SS-nlzR_13Ru1z67vDHdrHG7qnwYEMG3h8Ak6zpXTTB-vTEKQV5Apa5j3vuzvd4_-IB9Pfr-XSrHgDIq6sq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17175917</pqid></control><display><type>article</type><title>Is endogenous d‐serine in the rostral anterior cingulate cortex necessary for pain‐related negative affect?</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via Wiley Online Library</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Free Full-Text Journals in Chemistry</source><creator>Ren, Wen‐Hua ; Guo, Ji‐Dong ; Cao, Hong ; Wang, Hua ; Wang, Pei‐Fen ; Sha, Hong ; Ji, Ru‐Rong ; Zhao, Zhi‐Qi ; Zhang, Yu‐Qiu</creator><creatorcontrib>Ren, Wen‐Hua ; Guo, Ji‐Dong ; Cao, Hong ; Wang, Hua ; Wang, Pei‐Fen ; Sha, Hong ; Ji, Ru‐Rong ; Zhao, Zhi‐Qi ; Zhang, Yu‐Qiu</creatorcontrib><description>Functional activation of NMDA receptors requires co‐activation of glutamate‐ and glycine‐binding sites. d‐serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin‐induced conditioned place avoidance (F‐CPA) behavioral model and whole‐cell patch‐clamp recording in rostral anterior cingulate cortex (rACC) slices, we examined the effects of d‐amino acid oxidase (DAAO), an endogenous d‐serine‐degrading enzyme, and 7‐chlorokynurenate (7Cl‐KYNA), an antagonist of the glycine site of NMDA receptors, on pain‐related aversion. Degradation of endogenous d‐serine with DAAO, or selective blockade of the glycine site of NMDA receptors by 7Cl‐KYNA, effectively inhibited NMDA‐evoked currents in rACC slices. Intra‐rACC injection of DAAO (0.1 U) and 7Cl‐KYNA (2 and 0.2 mm, 0.6 µL per side) 20 min before F‐CPA conditioning greatly attenuated F‐CPA scores, but did not affect formalin‐induced acute nociceptive behaviors and electric foot shock‐induced conditioned place avoidance. This study reveals for the first time that endogenous d‐serine plays a critical role in pain‐related aversion by activating the glycine site of NMDA receptors in the rACC. Furthermore, these results extend our hypothesis that activation of NMDA receptors in the rACC is necessary for the acquisition of specific pain‐related negative emotion. Thus a new and promising strategy for the prevention of chronic pain‐induced emotional disturbance might be raised.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.2006.03677.x</identifier><identifier>PMID: 16476080</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adrenals. Interrenals ; Adrenomedullary hormones. Regulation ; Animals ; Anxiety - etiology ; Anxiety - metabolism ; Anxiety - physiopathology ; Biological and medical sciences ; conditioned place avoidance ; D-Amino-Acid Oxidase - pharmacology ; Excitatory Amino Acid Antagonists - pharmacology ; Fear - drug effects ; Fear - physiology ; Fundamental and applied biological sciences. Psychology ; Glycine - metabolism ; glycine site of N‐methyl‐d‐aspartate receptors ; Gyrus Cinguli - metabolism ; Gyrus Cinguli - physiopathology ; Kynurenic Acid - analogs & derivatives ; Kynurenic Acid - pharmacology ; Male ; Membrane Potentials - drug effects ; Membrane Potentials - physiology ; Molecular and cellular biology ; Molecular genetics ; N-Methylaspartate - pharmacology ; Organ Culture Techniques ; Pain - metabolism ; Pain - physiopathology ; Pain - psychology ; Pain Measurement ; Pain Threshold - drug effects ; Pain Threshold - physiology ; pain‐related negative affect ; Patch-Clamp Techniques ; rat ; Rats ; Rats, Sprague-Dawley ; Receptors, Glycine - metabolism ; Receptors, N-Methyl-D-Aspartate - metabolism ; rostral anterior cingulate cortex ; Serine - metabolism ; Stress, Psychological - etiology ; Stress, Psychological - metabolism ; Stress, Psychological - physiopathology ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Transcription. Transcription factor. Splicing. Rna processing ; Vertebrates: endocrinology ; whole‐cell recording</subject><ispartof>Journal of neurochemistry, 2006-03, Vol.96 (6), p.1636-1647</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5447-f914ad2ff598606715ea0c22e5e06551a86e5bfcf3f550be2a372959d9855c7d3</citedby><cites>FETCH-LOGICAL-c5447-f914ad2ff598606715ea0c22e5e06551a86e5bfcf3f550be2a372959d9855c7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.2006.03677.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.2006.03677.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17701731$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16476080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Wen‐Hua</creatorcontrib><creatorcontrib>Guo, Ji‐Dong</creatorcontrib><creatorcontrib>Cao, Hong</creatorcontrib><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Wang, Pei‐Fen</creatorcontrib><creatorcontrib>Sha, Hong</creatorcontrib><creatorcontrib>Ji, Ru‐Rong</creatorcontrib><creatorcontrib>Zhao, Zhi‐Qi</creatorcontrib><creatorcontrib>Zhang, Yu‐Qiu</creatorcontrib><title>Is endogenous d‐serine in the rostral anterior cingulate cortex necessary for pain‐related negative affect?</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>Functional activation of NMDA receptors requires co‐activation of glutamate‐ and glycine‐binding sites. d‐serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin‐induced conditioned place avoidance (F‐CPA) behavioral model and whole‐cell patch‐clamp recording in rostral anterior cingulate cortex (rACC) slices, we examined the effects of d‐amino acid oxidase (DAAO), an endogenous d‐serine‐degrading enzyme, and 7‐chlorokynurenate (7Cl‐KYNA), an antagonist of the glycine site of NMDA receptors, on pain‐related aversion. Degradation of endogenous d‐serine with DAAO, or selective blockade of the glycine site of NMDA receptors by 7Cl‐KYNA, effectively inhibited NMDA‐evoked currents in rACC slices. Intra‐rACC injection of DAAO (0.1 U) and 7Cl‐KYNA (2 and 0.2 mm, 0.6 µL per side) 20 min before F‐CPA conditioning greatly attenuated F‐CPA scores, but did not affect formalin‐induced acute nociceptive behaviors and electric foot shock‐induced conditioned place avoidance. This study reveals for the first time that endogenous d‐serine plays a critical role in pain‐related aversion by activating the glycine site of NMDA receptors in the rACC. Furthermore, these results extend our hypothesis that activation of NMDA receptors in the rACC is necessary for the acquisition of specific pain‐related negative emotion. Thus a new and promising strategy for the prevention of chronic pain‐induced emotional disturbance might be raised.</description><subject>Adrenals. Interrenals</subject><subject>Adrenomedullary hormones. Regulation</subject><subject>Animals</subject><subject>Anxiety - etiology</subject><subject>Anxiety - metabolism</subject><subject>Anxiety - physiopathology</subject><subject>Biological and medical sciences</subject><subject>conditioned place avoidance</subject><subject>D-Amino-Acid Oxidase - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Fear - drug effects</subject><subject>Fear - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycine - metabolism</subject><subject>glycine site of N‐methyl‐d‐aspartate receptors</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Kynurenic Acid - analogs & derivatives</subject><subject>Kynurenic Acid - pharmacology</subject><subject>Male</subject><subject>Membrane Potentials - drug effects</subject><subject>Membrane Potentials - physiology</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>N-Methylaspartate - pharmacology</subject><subject>Organ Culture Techniques</subject><subject>Pain - metabolism</subject><subject>Pain - physiopathology</subject><subject>Pain - psychology</subject><subject>Pain Measurement</subject><subject>Pain Threshold - drug effects</subject><subject>Pain Threshold - physiology</subject><subject>pain‐related negative affect</subject><subject>Patch-Clamp Techniques</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Glycine - metabolism</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>rostral anterior cingulate cortex</subject><subject>Serine - metabolism</subject><subject>Stress, Psychological - etiology</subject><subject>Stress, Psychological - metabolism</subject><subject>Stress, Psychological - physiopathology</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Transcription. Transcription factor. Splicing. Rna processing</subject><subject>Vertebrates: endocrinology</subject><subject>whole‐cell recording</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi3Uii4tr4B8obeEsRPbyQEhtCpQVJULPVteZ7x4lXUWO9tubzwCz8iT1GFX7bH1ZSzPN-OZ_yeEMihZPh9WJasVK2om2pIDyBIqqVS5e0Vmj4kjMgPgvKig5ifkTUorACZryV6TkxyVhAZmZLhMFEM3LDEM20S7f3_-Jow-IPWBjr-QxiGN0fTUhDG_D5FaH5bb3oxI7RBH3NGAFlMy8Z66nN4YH3KTiBPS5eTSjP4WqXEO7fjpjBw70yd8e4in5ObLxc_5t-Lqx9fL-eerwoq6VoVrWW067pxoGwlSMYEGLOcoEKQQzDQSxcJZVzkhYIHcVIq3ou3aRgiruuqUnO_7buLwe4tp1GufLPa9CZgX1VkuUbeqeRZkiinRMpXBZg_aLEmK6PQm-nVeWzPQkyt6pSfx9SS-nlzR_13Ru1z67vDHdrHG7qnwYEMG3h8Ak6zpXTTB-vTEKQV5Apa5j3vuzvd4_-IB9Pfr-XSrHgDIq6sq</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Ren, Wen‐Hua</creator><creator>Guo, Ji‐Dong</creator><creator>Cao, Hong</creator><creator>Wang, Hua</creator><creator>Wang, Pei‐Fen</creator><creator>Sha, Hong</creator><creator>Ji, Ru‐Rong</creator><creator>Zhao, Zhi‐Qi</creator><creator>Zhang, Yu‐Qiu</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Is endogenous d‐serine in the rostral anterior cingulate cortex necessary for pain‐related negative affect?</title><author>Ren, Wen‐Hua ; Guo, Ji‐Dong ; Cao, Hong ; Wang, Hua ; Wang, Pei‐Fen ; Sha, Hong ; Ji, Ru‐Rong ; Zhao, Zhi‐Qi ; Zhang, Yu‐Qiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5447-f914ad2ff598606715ea0c22e5e06551a86e5bfcf3f550be2a372959d9855c7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adrenals. Interrenals</topic><topic>Adrenomedullary hormones. Regulation</topic><topic>Animals</topic><topic>Anxiety - etiology</topic><topic>Anxiety - metabolism</topic><topic>Anxiety - physiopathology</topic><topic>Biological and medical sciences</topic><topic>conditioned place avoidance</topic><topic>D-Amino-Acid Oxidase - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Fear - drug effects</topic><topic>Fear - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycine - metabolism</topic><topic>glycine site of N‐methyl‐d‐aspartate receptors</topic><topic>Gyrus Cinguli - metabolism</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Kynurenic Acid - analogs & derivatives</topic><topic>Kynurenic Acid - pharmacology</topic><topic>Male</topic><topic>Membrane Potentials - drug effects</topic><topic>Membrane Potentials - physiology</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>N-Methylaspartate - pharmacology</topic><topic>Organ Culture Techniques</topic><topic>Pain - metabolism</topic><topic>Pain - physiopathology</topic><topic>Pain - psychology</topic><topic>Pain Measurement</topic><topic>Pain Threshold - drug effects</topic><topic>Pain Threshold - physiology</topic><topic>pain‐related negative affect</topic><topic>Patch-Clamp Techniques</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Glycine - metabolism</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>rostral anterior cingulate cortex</topic><topic>Serine - metabolism</topic><topic>Stress, Psychological - etiology</topic><topic>Stress, Psychological - metabolism</topic><topic>Stress, Psychological - physiopathology</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><topic>Transcription. Transcription factor. Splicing. Rna processing</topic><topic>Vertebrates: endocrinology</topic><topic>whole‐cell recording</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Wen‐Hua</creatorcontrib><creatorcontrib>Guo, Ji‐Dong</creatorcontrib><creatorcontrib>Cao, Hong</creatorcontrib><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Wang, Pei‐Fen</creatorcontrib><creatorcontrib>Sha, Hong</creatorcontrib><creatorcontrib>Ji, Ru‐Rong</creatorcontrib><creatorcontrib>Zhao, Zhi‐Qi</creatorcontrib><creatorcontrib>Zhang, Yu‐Qiu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Wen‐Hua</au><au>Guo, Ji‐Dong</au><au>Cao, Hong</au><au>Wang, Hua</au><au>Wang, Pei‐Fen</au><au>Sha, Hong</au><au>Ji, Ru‐Rong</au><au>Zhao, Zhi‐Qi</au><au>Zhang, Yu‐Qiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is endogenous d‐serine in the rostral anterior cingulate cortex necessary for pain‐related negative affect?</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2006-03</date><risdate>2006</risdate><volume>96</volume><issue>6</issue><spage>1636</spage><epage>1647</epage><pages>1636-1647</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>Functional activation of NMDA receptors requires co‐activation of glutamate‐ and glycine‐binding sites. d‐serine is considered to be an endogenous ligand for the glycine site of NMDA receptors. Using a combination of a rat formalin‐induced conditioned place avoidance (F‐CPA) behavioral model and whole‐cell patch‐clamp recording in rostral anterior cingulate cortex (rACC) slices, we examined the effects of d‐amino acid oxidase (DAAO), an endogenous d‐serine‐degrading enzyme, and 7‐chlorokynurenate (7Cl‐KYNA), an antagonist of the glycine site of NMDA receptors, on pain‐related aversion. Degradation of endogenous d‐serine with DAAO, or selective blockade of the glycine site of NMDA receptors by 7Cl‐KYNA, effectively inhibited NMDA‐evoked currents in rACC slices. Intra‐rACC injection of DAAO (0.1 U) and 7Cl‐KYNA (2 and 0.2 mm, 0.6 µL per side) 20 min before F‐CPA conditioning greatly attenuated F‐CPA scores, but did not affect formalin‐induced acute nociceptive behaviors and electric foot shock‐induced conditioned place avoidance. This study reveals for the first time that endogenous d‐serine plays a critical role in pain‐related aversion by activating the glycine site of NMDA receptors in the rACC. Furthermore, these results extend our hypothesis that activation of NMDA receptors in the rACC is necessary for the acquisition of specific pain‐related negative emotion. Thus a new and promising strategy for the prevention of chronic pain‐induced emotional disturbance might be raised.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16476080</pmid><doi>10.1111/j.1471-4159.2006.03677.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 2006-03, Vol.96 (6), p.1636-1647 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67754978 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; Wiley Online Library (Open Access Collection); Free Full-Text Journals in Chemistry |
| subjects | Adrenals. Interrenals Adrenomedullary hormones. Regulation Animals Anxiety - etiology Anxiety - metabolism Anxiety - physiopathology Biological and medical sciences conditioned place avoidance D-Amino-Acid Oxidase - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fear - drug effects Fear - physiology Fundamental and applied biological sciences. Psychology Glycine - metabolism glycine site of N‐methyl‐d‐aspartate receptors Gyrus Cinguli - metabolism Gyrus Cinguli - physiopathology Kynurenic Acid - analogs & derivatives Kynurenic Acid - pharmacology Male Membrane Potentials - drug effects Membrane Potentials - physiology Molecular and cellular biology Molecular genetics N-Methylaspartate - pharmacology Organ Culture Techniques Pain - metabolism Pain - physiopathology Pain - psychology Pain Measurement Pain Threshold - drug effects Pain Threshold - physiology pain‐related negative affect Patch-Clamp Techniques rat Rats Rats, Sprague-Dawley Receptors, Glycine - metabolism Receptors, N-Methyl-D-Aspartate - metabolism rostral anterior cingulate cortex Serine - metabolism Stress, Psychological - etiology Stress, Psychological - metabolism Stress, Psychological - physiopathology Synaptic Transmission - drug effects Synaptic Transmission - physiology Transcription. Transcription factor. Splicing. Rna processing Vertebrates: endocrinology whole‐cell recording |
| title | Is endogenous d‐serine in the rostral anterior cingulate cortex necessary for pain‐related negative affect? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T10%3A08%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20endogenous%20d%E2%80%90serine%20in%20the%20rostral%20anterior%20cingulate%20cortex%20necessary%20for%20pain%E2%80%90related%20negative%20affect?&rft.jtitle=Journal%20of%20neurochemistry&rft.au=Ren,%20Wen%E2%80%90Hua&rft.date=2006-03&rft.volume=96&rft.issue=6&rft.spage=1636&rft.epage=1647&rft.pages=1636-1647&rft.issn=0022-3042&rft.eissn=1471-4159&rft.coden=JONRA9&rft_id=info:doi/10.1111/j.1471-4159.2006.03677.x&rft_dat=%3Cproquest_cross%3E67754978%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17175917&rft_id=info:pmid/16476080&rfr_iscdi=true |