Constitutive Expression of the Period1 Gene Impairs Behavioral and Molecular Circadian Rhythms

Three mammalian Period (Per) genes, termed Per1, Per2, and Per3, have been identified as structural homologues of the Drosophila circadian clock gene, period (per). The three Per genes are rhythmically expressed in the suprachiasmatic nucleus (SCN), the central circadian pacemaker in mammals. The ph...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-03, Vol.103 (10), p.3716-3721
Hauptverfasser:	Numano, Rika, Yamazaki, Shin, Umeda, Nanae, Samura, Tomonori, Sujino, Mitsugu, Takahashi, Ri-ichi, Ueda, Masatsugu, Mori, Akiko, Yamada, Kazunori, Sakaki, Yoshiyuki, Inouye, Shin-Ichi T., Menaker, Michael, Tei, Hajime
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Base Sequence Behavior, Animal - physiology Biological Sciences Body temperature Cell Cycle Proteins Circadian rhythm Circadian Rhythm - genetics Circadian Rhythm - physiology Drosophila Eye - metabolism Female Gene Expression Genes Genetics Genomics Male Male animals Mammals Messenger RNA Mice Nuclear Proteins - genetics Nuclear Proteins - physiology Period Circadian Proteins Rats Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Siblings Suprachiasmatic Nucleus - metabolism Transcription Factors - genetics Transcription Factors - physiology Transgenes Transgenic animals
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