Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders
Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and thos...
Gespeichert in:
| Veröffentlicht in: | Acta neuropathologica 2005-04, Vol.109 (3), p.256-262 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 262 |
|---|---|
| container_issue | 3 |
| container_start_page | 256 |
| container_title | Acta neuropathologica |
| container_volume | 109 |
| creator | Fukae, Jiro Takanashi, Masashi Kubo, Shin-ichiro Nishioka, Ken-ichi Nakabeppu, Yusaku Mori, Hideo Mizuno, Yoshikuni Hattori, Nobutaka |
| description | Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD. |
| doi_str_mv | 10.1007/s00401-004-0937-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67753750</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>828834111</sourcerecordid><originalsourceid>FETCH-LOGICAL-p236t-3b991e5d94043f85f6fba12adf747915e33e884f719b77ee7ea5d8ac461e88f13</originalsourceid><addsrcrecordid>eNpdkE9LAzEQxYMotlY_gBcJHvxziCabZLN7LLVWoVgPel6yzWxZ3SZrsivttzfFepGBN8y8H49hEDpn9I5Rqu4DpYIyEpXQnCuSH6AhEzwhVHJ-iIaURjflSTJAJyF8xClRQh6jAZOZYLGGqJ1uWg8h1M5iV-GMuI1b9drWFvDDyxivmu3ShW2jA-CbxWzGbnFt8av2n7UNzl4HbOoAO1dbgz00ugODLfTeGViBBa-7-ht2lPMGfDhFR5VuApzt-wi9P07fJk9kvpg9T8Zz0iY87Qgv85yBNLmggleZrNKq1CzRplJC5UwC55BlolIsL5UCUKClyfRSpCzuK8ZH6Oo3t_Xuq4fQFes6LKFptAXXhyJVSnIlaQQv_4Efrvc23lYkjKk8oZmI0MUe6ss1mKL19Vr7bfH3SP4DUkN1PA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211792084</pqid></control><display><type>article</type><title>Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Fukae, Jiro ; Takanashi, Masashi ; Kubo, Shin-ichiro ; Nishioka, Ken-ichi ; Nakabeppu, Yusaku ; Mori, Hideo ; Mizuno, Yoshikuni ; Hattori, Nobutaka</creator><creatorcontrib>Fukae, Jiro ; Takanashi, Masashi ; Kubo, Shin-ichiro ; Nishioka, Ken-ichi ; Nakabeppu, Yusaku ; Mori, Hideo ; Mizuno, Yoshikuni ; Hattori, Nobutaka</creatorcontrib><description>Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s00401-004-0937-9</identifier><identifier>PMID: 15841414</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Basal Ganglia Diseases - enzymology ; Blotting, Western - methods ; Brain - enzymology ; Brain - pathology ; Case-Control Studies ; Cell Count - methods ; DNA Glycosylases - metabolism ; Electron Transport Complex IV - metabolism ; Female ; Gene Expression Regulation - physiology ; Humans ; Immunohistochemistry - methods ; Male ; Middle Aged ; Neurons - metabolism ; Parkinson Disease - enzymology ; Postmortem Changes ; Subcellular Fractions - enzymology ; Supranuclear Palsy, Progressive - enzymology ; Time Factors ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>Acta neuropathologica, 2005-04, Vol.109 (3), p.256-262</ispartof><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15841414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukae, Jiro</creatorcontrib><creatorcontrib>Takanashi, Masashi</creatorcontrib><creatorcontrib>Kubo, Shin-ichiro</creatorcontrib><creatorcontrib>Nishioka, Ken-ichi</creatorcontrib><creatorcontrib>Nakabeppu, Yusaku</creatorcontrib><creatorcontrib>Mori, Hideo</creatorcontrib><creatorcontrib>Mizuno, Yoshikuni</creatorcontrib><creatorcontrib>Hattori, Nobutaka</creatorcontrib><title>Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Basal Ganglia Diseases - enzymology</subject><subject>Blotting, Western - methods</subject><subject>Brain - enzymology</subject><subject>Brain - pathology</subject><subject>Case-Control Studies</subject><subject>Cell Count - methods</subject><subject>DNA Glycosylases - metabolism</subject><subject>Electron Transport Complex IV - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation - physiology</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurons - metabolism</subject><subject>Parkinson Disease - enzymology</subject><subject>Postmortem Changes</subject><subject>Subcellular Fractions - enzymology</subject><subject>Supranuclear Palsy, Progressive - enzymology</subject><subject>Time Factors</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkE9LAzEQxYMotlY_gBcJHvxziCabZLN7LLVWoVgPel6yzWxZ3SZrsivttzfFepGBN8y8H49hEDpn9I5Rqu4DpYIyEpXQnCuSH6AhEzwhVHJ-iIaURjflSTJAJyF8xClRQh6jAZOZYLGGqJ1uWg8h1M5iV-GMuI1b9drWFvDDyxivmu3ShW2jA-CbxWzGbnFt8av2n7UNzl4HbOoAO1dbgz00ugODLfTeGViBBa-7-ht2lPMGfDhFR5VuApzt-wi9P07fJk9kvpg9T8Zz0iY87Qgv85yBNLmggleZrNKq1CzRplJC5UwC55BlolIsL5UCUKClyfRSpCzuK8ZH6Oo3t_Xuq4fQFes6LKFptAXXhyJVSnIlaQQv_4Efrvc23lYkjKk8oZmI0MUe6ss1mKL19Vr7bfH3SP4DUkN1PA</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Fukae, Jiro</creator><creator>Takanashi, Masashi</creator><creator>Kubo, Shin-ichiro</creator><creator>Nishioka, Ken-ichi</creator><creator>Nakabeppu, Yusaku</creator><creator>Mori, Hideo</creator><creator>Mizuno, Yoshikuni</creator><creator>Hattori, Nobutaka</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders</title><author>Fukae, Jiro ; Takanashi, Masashi ; Kubo, Shin-ichiro ; Nishioka, Ken-ichi ; Nakabeppu, Yusaku ; Mori, Hideo ; Mizuno, Yoshikuni ; Hattori, Nobutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-3b991e5d94043f85f6fba12adf747915e33e884f719b77ee7ea5d8ac461e88f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Basal Ganglia Diseases - enzymology</topic><topic>Blotting, Western - methods</topic><topic>Brain - enzymology</topic><topic>Brain - pathology</topic><topic>Case-Control Studies</topic><topic>Cell Count - methods</topic><topic>DNA Glycosylases - metabolism</topic><topic>Electron Transport Complex IV - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation - physiology</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurons - metabolism</topic><topic>Parkinson Disease - enzymology</topic><topic>Postmortem Changes</topic><topic>Subcellular Fractions - enzymology</topic><topic>Supranuclear Palsy, Progressive - enzymology</topic><topic>Time Factors</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukae, Jiro</creatorcontrib><creatorcontrib>Takanashi, Masashi</creatorcontrib><creatorcontrib>Kubo, Shin-ichiro</creatorcontrib><creatorcontrib>Nishioka, Ken-ichi</creatorcontrib><creatorcontrib>Nakabeppu, Yusaku</creatorcontrib><creatorcontrib>Mori, Hideo</creatorcontrib><creatorcontrib>Mizuno, Yoshikuni</creatorcontrib><creatorcontrib>Hattori, Nobutaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukae, Jiro</au><au>Takanashi, Masashi</au><au>Kubo, Shin-ichiro</au><au>Nishioka, Ken-ichi</au><au>Nakabeppu, Yusaku</au><au>Mori, Hideo</au><au>Mizuno, Yoshikuni</au><au>Hattori, Nobutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>109</volume><issue>3</issue><spage>256</spage><epage>262</epage><pages>256-262</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><abstract>Oxidative stress including DNA oxidation is implicated in Parkinson's disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15841414</pmid><doi>10.1007/s00401-004-0937-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6322 |
| ispartof | Acta neuropathologica, 2005-04, Vol.109 (3), p.256-262 |
| issn | 0001-6322 1432-0533 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67753750 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Age Factors Aged Aged, 80 and over Basal Ganglia Diseases - enzymology Blotting, Western - methods Brain - enzymology Brain - pathology Case-Control Studies Cell Count - methods DNA Glycosylases - metabolism Electron Transport Complex IV - metabolism Female Gene Expression Regulation - physiology Humans Immunohistochemistry - methods Male Middle Aged Neurons - metabolism Parkinson Disease - enzymology Postmortem Changes Subcellular Fractions - enzymology Supranuclear Palsy, Progressive - enzymology Time Factors Tyrosine 3-Monooxygenase - metabolism |
| title | Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T01%3A56%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%208-oxoguanine%20DNA%20glycosylase%20(OGG1)%20in%20Parkinson's%20disease%20and%20related%20neurodegenerative%20disorders&rft.jtitle=Acta%20neuropathologica&rft.au=Fukae,%20Jiro&rft.date=2005-04-01&rft.volume=109&rft.issue=3&rft.spage=256&rft.epage=262&rft.pages=256-262&rft.issn=0001-6322&rft.eissn=1432-0533&rft_id=info:doi/10.1007/s00401-004-0937-9&rft_dat=%3Cproquest_pubme%3E828834111%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=211792084&rft_id=info:pmid/15841414&rfr_iscdi=true |