Diagnosis of gastroesophageal reflux disease using a new questionnaire
Background and Aim: An early and accurate evaluation by a general practitioner is needed to screen out non‐gastroesophageal reflux disease (GERD) patients. A recent questionnaire (QUEST) highlighted problems with specificity and complexity, so the aim of the present study was to design a simplified...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2005-04, Vol.20 (4), p.643-647 |
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| creator | SHIMOYAMA, YASUYUKI KUSANO, MOTOYASU SUGIMOTO, SAYAKA KAWAMURA, OSAMU MAEDA, MASAKI MINASHI, KEIKO KURIBAYASHI, SHIKOU HIGUCHI, TATSUYA ZAI, HIROAKI INO, KYOKO HORIKOSHI, TSUTOMU MOKI, FUMITAKA SUGIYAMA, TADASHI TOKI, MUNETOSHI OHWADA, TSUNEO MORI, MASATOMO |
| description | Background and Aim: An early and accurate evaluation by a general practitioner is needed to screen out non‐gastroesophageal reflux disease (GERD) patients. A recent questionnaire (QUEST) highlighted problems with specificity and complexity, so the aim of the present study was to design a simplified questionnaire.
Methods: When admitted to hospital to undergo an upper gastrointestinal endoscopy for suspected GERD, 333 patients completed a 50‐item questionnaire requiring ‘yes/no’ answers to different combinations of questions relating to symptoms of upper gastrointestinal tract conditions (e.g. GERD, ulcers and functional dyspepsia) and psychosomatic symptoms. The endoscopic diagnosis was then correlated with the rate of positive answers to each question.
Results: Based on the analysis of the 50 items, the 8–10 questions most often answered affirmatively by each of the GERD and non‐GERD groups were chosen for the simplified questionnaire. Three draft questionnaires were compiled. After calculating the sensitivity, specificity and accuracy in relation to the diagnosis of GERD and other conditions, it was found that questionnaire B (selection of persons answering ‘yes’ to at least one of questions 1–5 and exclusion of persons answering ‘yes’ to at least three of questions 7–10) had a high sensitivity, high specificity and low false positive rate.
Conclusion: A novel questionnaire was developed. It was designed to detect the symptoms of GERD while simultaneously excluding non‐GERD patients. This simplified nine‐item simplified questionnaire had a sensitivity of 79.8%, a specificity of 53.6% and an accuracy of 63.4%. |
| doi_str_mv | 10.1111/j.1440-1746.2005.03776.x |
| format | Article |
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Methods: When admitted to hospital to undergo an upper gastrointestinal endoscopy for suspected GERD, 333 patients completed a 50‐item questionnaire requiring ‘yes/no’ answers to different combinations of questions relating to symptoms of upper gastrointestinal tract conditions (e.g. GERD, ulcers and functional dyspepsia) and psychosomatic symptoms. The endoscopic diagnosis was then correlated with the rate of positive answers to each question.
Results: Based on the analysis of the 50 items, the 8–10 questions most often answered affirmatively by each of the GERD and non‐GERD groups were chosen for the simplified questionnaire. Three draft questionnaires were compiled. After calculating the sensitivity, specificity and accuracy in relation to the diagnosis of GERD and other conditions, it was found that questionnaire B (selection of persons answering ‘yes’ to at least one of questions 1–5 and exclusion of persons answering ‘yes’ to at least three of questions 7–10) had a high sensitivity, high specificity and low false positive rate.
Conclusion: A novel questionnaire was developed. It was designed to detect the symptoms of GERD while simultaneously excluding non‐GERD patients. This simplified nine‐item simplified questionnaire had a sensitivity of 79.8%, a specificity of 53.6% and an accuracy of 63.4%.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.2005.03776.x</identifier><identifier>PMID: 15836717</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Biological and medical sciences ; Chi-Square Distribution ; diagnosis ; Diagnosis, Differential ; Endoscopy, Gastrointestinal ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - diagnosis ; gastroesophageal reflux disease ; Humans ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; psychosomatic symptoms ; QUEST ; questionnaire ; Reproducibility of Results ; Sensitivity and Specificity ; Surveys and Questionnaires</subject><ispartof>Journal of gastroenterology and hepatology, 2005-04, Vol.20 (4), p.643-647</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4356-a51aa62ebcc03e6429ecb150129e2da88aaaaf1a9a73d4ab24fb0386c7c81ff73</citedby><cites>FETCH-LOGICAL-c4356-a51aa62ebcc03e6429ecb150129e2da88aaaaf1a9a73d4ab24fb0386c7c81ff73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1746.2005.03776.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1746.2005.03776.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16779271$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15836717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIMOYAMA, YASUYUKI</creatorcontrib><creatorcontrib>KUSANO, MOTOYASU</creatorcontrib><creatorcontrib>SUGIMOTO, SAYAKA</creatorcontrib><creatorcontrib>KAWAMURA, OSAMU</creatorcontrib><creatorcontrib>MAEDA, MASAKI</creatorcontrib><creatorcontrib>MINASHI, KEIKO</creatorcontrib><creatorcontrib>KURIBAYASHI, SHIKOU</creatorcontrib><creatorcontrib>HIGUCHI, TATSUYA</creatorcontrib><creatorcontrib>ZAI, HIROAKI</creatorcontrib><creatorcontrib>INO, KYOKO</creatorcontrib><creatorcontrib>HORIKOSHI, TSUTOMU</creatorcontrib><creatorcontrib>MOKI, FUMITAKA</creatorcontrib><creatorcontrib>SUGIYAMA, TADASHI</creatorcontrib><creatorcontrib>TOKI, MUNETOSHI</creatorcontrib><creatorcontrib>OHWADA, TSUNEO</creatorcontrib><creatorcontrib>MORI, MASATOMO</creatorcontrib><title>Diagnosis of gastroesophageal reflux disease using a new questionnaire</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim: An early and accurate evaluation by a general practitioner is needed to screen out non‐gastroesophageal reflux disease (GERD) patients. A recent questionnaire (QUEST) highlighted problems with specificity and complexity, so the aim of the present study was to design a simplified questionnaire.
Methods: When admitted to hospital to undergo an upper gastrointestinal endoscopy for suspected GERD, 333 patients completed a 50‐item questionnaire requiring ‘yes/no’ answers to different combinations of questions relating to symptoms of upper gastrointestinal tract conditions (e.g. GERD, ulcers and functional dyspepsia) and psychosomatic symptoms. The endoscopic diagnosis was then correlated with the rate of positive answers to each question.
Results: Based on the analysis of the 50 items, the 8–10 questions most often answered affirmatively by each of the GERD and non‐GERD groups were chosen for the simplified questionnaire. Three draft questionnaires were compiled. After calculating the sensitivity, specificity and accuracy in relation to the diagnosis of GERD and other conditions, it was found that questionnaire B (selection of persons answering ‘yes’ to at least one of questions 1–5 and exclusion of persons answering ‘yes’ to at least three of questions 7–10) had a high sensitivity, high specificity and low false positive rate.
Conclusion: A novel questionnaire was developed. It was designed to detect the symptoms of GERD while simultaneously excluding non‐GERD patients. This simplified nine‐item simplified questionnaire had a sensitivity of 79.8%, a specificity of 53.6% and an accuracy of 63.4%.</description><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - diagnosis</subject><subject>gastroesophageal reflux disease</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>psychosomatic symptoms</subject><subject>QUEST</subject><subject>questionnaire</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Surveys and Questionnaires</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PGzEQhq2qVQnQv4B8aW-72Ouv3UMPFS2BigQJterRmnW8welmN3iyIvx7vCSCK3PxSH5ee-YhhHKW81Tnq5xLyTJupM4LxlTOhDE6330gk9eLj2TCSq6ySvDqiBwjrhhjkhn1mRxxVQptuJmQy58Bll2PAWnf0CXgNvYe-809LD20NPqmHXZ0EdADejpg6JYUaOcf6cPgcRv6roMQ_Sn51ECL_svhPCF_L3_9ubjKbm6n1xc_bjInhdIZKA6gC187x4TXsqi8q7liPDXFAsoSUjUcKjBiIaEuZFMzUWpnXMmbxogT8m3_7ib2LwPYdUDn2xY63w9otTFKiKpIYLkHXewR0xp2E8Ma4pPlzI4O7cqOquyoyo4O7YtDu0vRs8MfQ732i7fgQVoCvh4AQAdtE6FzAd-4NERVGJ6473vuMbT-6d0D2N_Tq7FL-WyfD7j1u9c8xP9pT2GU_Tef2rs5n8_kbGa1eAawUp0A</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>SHIMOYAMA, YASUYUKI</creator><creator>KUSANO, MOTOYASU</creator><creator>SUGIMOTO, SAYAKA</creator><creator>KAWAMURA, OSAMU</creator><creator>MAEDA, MASAKI</creator><creator>MINASHI, KEIKO</creator><creator>KURIBAYASHI, SHIKOU</creator><creator>HIGUCHI, TATSUYA</creator><creator>ZAI, HIROAKI</creator><creator>INO, KYOKO</creator><creator>HORIKOSHI, TSUTOMU</creator><creator>MOKI, FUMITAKA</creator><creator>SUGIYAMA, TADASHI</creator><creator>TOKI, MUNETOSHI</creator><creator>OHWADA, TSUNEO</creator><creator>MORI, MASATOMO</creator><general>Blackwell Science Pty</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>Diagnosis of gastroesophageal reflux disease using a new questionnaire</title><author>SHIMOYAMA, YASUYUKI ; KUSANO, MOTOYASU ; SUGIMOTO, SAYAKA ; KAWAMURA, OSAMU ; MAEDA, MASAKI ; MINASHI, KEIKO ; KURIBAYASHI, SHIKOU ; HIGUCHI, TATSUYA ; ZAI, HIROAKI ; INO, KYOKO ; HORIKOSHI, TSUTOMU ; MOKI, FUMITAKA ; SUGIYAMA, TADASHI ; TOKI, MUNETOSHI ; OHWADA, TSUNEO ; MORI, MASATOMO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4356-a51aa62ebcc03e6429ecb150129e2da88aaaaf1a9a73d4ab24fb0386c7c81ff73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - diagnosis</topic><topic>gastroesophageal reflux disease</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>psychosomatic symptoms</topic><topic>QUEST</topic><topic>questionnaire</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIMOYAMA, YASUYUKI</creatorcontrib><creatorcontrib>KUSANO, MOTOYASU</creatorcontrib><creatorcontrib>SUGIMOTO, SAYAKA</creatorcontrib><creatorcontrib>KAWAMURA, OSAMU</creatorcontrib><creatorcontrib>MAEDA, MASAKI</creatorcontrib><creatorcontrib>MINASHI, KEIKO</creatorcontrib><creatorcontrib>KURIBAYASHI, SHIKOU</creatorcontrib><creatorcontrib>HIGUCHI, TATSUYA</creatorcontrib><creatorcontrib>ZAI, HIROAKI</creatorcontrib><creatorcontrib>INO, KYOKO</creatorcontrib><creatorcontrib>HORIKOSHI, TSUTOMU</creatorcontrib><creatorcontrib>MOKI, FUMITAKA</creatorcontrib><creatorcontrib>SUGIYAMA, TADASHI</creatorcontrib><creatorcontrib>TOKI, MUNETOSHI</creatorcontrib><creatorcontrib>OHWADA, TSUNEO</creatorcontrib><creatorcontrib>MORI, MASATOMO</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIMOYAMA, YASUYUKI</au><au>KUSANO, MOTOYASU</au><au>SUGIMOTO, SAYAKA</au><au>KAWAMURA, OSAMU</au><au>MAEDA, MASAKI</au><au>MINASHI, KEIKO</au><au>KURIBAYASHI, SHIKOU</au><au>HIGUCHI, TATSUYA</au><au>ZAI, HIROAKI</au><au>INO, KYOKO</au><au>HORIKOSHI, TSUTOMU</au><au>MOKI, FUMITAKA</au><au>SUGIYAMA, TADASHI</au><au>TOKI, MUNETOSHI</au><au>OHWADA, TSUNEO</au><au>MORI, MASATOMO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of gastroesophageal reflux disease using a new questionnaire</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2005-04</date><risdate>2005</risdate><volume>20</volume><issue>4</issue><spage>643</spage><epage>647</epage><pages>643-647</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim: An early and accurate evaluation by a general practitioner is needed to screen out non‐gastroesophageal reflux disease (GERD) patients. A recent questionnaire (QUEST) highlighted problems with specificity and complexity, so the aim of the present study was to design a simplified questionnaire.
Methods: When admitted to hospital to undergo an upper gastrointestinal endoscopy for suspected GERD, 333 patients completed a 50‐item questionnaire requiring ‘yes/no’ answers to different combinations of questions relating to symptoms of upper gastrointestinal tract conditions (e.g. GERD, ulcers and functional dyspepsia) and psychosomatic symptoms. The endoscopic diagnosis was then correlated with the rate of positive answers to each question.
Results: Based on the analysis of the 50 items, the 8–10 questions most often answered affirmatively by each of the GERD and non‐GERD groups were chosen for the simplified questionnaire. Three draft questionnaires were compiled. After calculating the sensitivity, specificity and accuracy in relation to the diagnosis of GERD and other conditions, it was found that questionnaire B (selection of persons answering ‘yes’ to at least one of questions 1–5 and exclusion of persons answering ‘yes’ to at least three of questions 7–10) had a high sensitivity, high specificity and low false positive rate.
Conclusion: A novel questionnaire was developed. It was designed to detect the symptoms of GERD while simultaneously excluding non‐GERD patients. This simplified nine‐item simplified questionnaire had a sensitivity of 79.8%, a specificity of 53.6% and an accuracy of 63.4%.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>15836717</pmid><doi>10.1111/j.1440-1746.2005.03776.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Chi-Square Distribution diagnosis Diagnosis, Differential Endoscopy, Gastrointestinal Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - diagnosis gastroesophageal reflux disease Humans Male Medical sciences Middle Aged Other diseases. Semiology psychosomatic symptoms QUEST questionnaire Reproducibility of Results Sensitivity and Specificity Surveys and Questionnaires |
| title | Diagnosis of gastroesophageal reflux disease using a new questionnaire |
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