Differential Regulation of Angiotensin II-induced Expression of Connective Tissue Growth Factor by Protein Kinase C Isoforms in the Myocardium

Protein kinase C (PKC) and angiotensin II (AngII) can regulate cardiac function in pathological conditions such as in diabetes or ischemic heart disease. We have reported that expression of connective tissue growth factor (CTGF) is increased in the myocardium of diabetic mice. Now we showed that the...

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Veröffentlicht in:	The Journal of biological chemistry 2005-04, Vol.280 (16), p.15719-15726
Hauptverfasser:	He, Zhiheng, Way, Kerrie J., Arikawa, Emi, Chou, Eva, Opland, Darren M., Clermont, Allen, Isshiki, Keiji, Ma, Ronald C.W., Scott, Joshua A., Schoen, Frederick J., Feener, Edward P., King, George L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Cells, Cultured Connective Tissue Growth Factor Diabetes Mellitus Gene Expression Regulation - physiology Immediate-Early Proteins - biosynthesis Immediate-Early Proteins - genetics Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - genetics Isoenzymes - metabolism Mice Myocardium - metabolism Myocytes, Cardiac - metabolism Protein Kinase C - metabolism Rats
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