Selective Ablation of Retinoblastoma Protein Function by the RET Finger Protein

The retinoblastoma tumor suppressor protein (Rb) affects gene transcription both negatively and positively and through this regulates distinct cellular responses. Although cell cycle regulation requires gene repression, Rb’s ability to promote differentiation and part of its antiproliferative activi...

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Veröffentlicht in:	Molecular cell 2005-04, Vol.18 (2), p.213-224
Hauptverfasser:	Krützfeldt, Maja, Ellis, Mark, Weekes, Daniel B., Bull, Jonathan J., Eilers, Martin, Vivanco, Maria d M., Sellers, William R., Mittnacht, Sibylle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1A Proteins - genetics Adenovirus E1A Proteins - metabolism Blotting, Western Cell Cycle Proteins - antagonists & inhibitors Cell Differentiation Cell Line, Tumor Cell Lineage DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E2F Transcription Factors Gene Expression Regulation Genes, Reporter Glutathione Transferase - metabolism Humans Luciferases - metabolism Models, Biological Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Oligonucleotide Array Sequence Analysis Osteosarcoma Precipitin Tests Promoter Regions, Genetic Protein Structure, Tertiary Recombinant Proteins - metabolism Repressor Proteins Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism RNA, Small Interfering - metabolism Structure-Activity Relationship Transcription Factors - antagonists & inhibitors Transcription, Genetic Two-Hybrid System Techniques
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