SRC-3/AIB1- transcriptional coactivator in oncogenesis

Steroid receptor coactivator-3 （SRC-3, also known as NCoA3, AIB 1, p/CIP, RAC3, ACTR, and TRAM 1）, localized on a frequently amplified region, 20q12, has been associated with multiple cancers, including breast, gastric and prostate cancers. Although SRC-3 has been implicated as an oncogene, compelling evidence has only recently emerged implicating it as a causal factor in the genesis of human cancers. Here, we summarize recent evidence that indicates aberrant SRC-3 expression is important in hormone-sensitive and -insensitive human cancers.