Variation of C-reactive protein levels in adolescents : Association with sleep-disordered breathing and sleep duration
There is increasing evidence that sleep-disordered breathing (SDB) is an independent risk factor for cardiovascular disease (CVD) in adults. C-reactive protein (CRP), a marker of systemic inflammation, is an important predictor of future cardiovascular events. The goal of this study was to quantify...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2005-04, Vol.111 (15), p.1978-1984 |
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| container_end_page | 1984 |
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| container_issue | 15 |
| container_start_page | 1978 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 111 |
| creator | LARKIN, Emma K ROSEN, Carol L KIRCHNER, H. Lester STORFER-ISSER, Amy EMANCIPATOR, Judith L JOHNSON, Nathan L ZAMBITO, Anna Marie V TRACY, Russell P JENNY, Nancy S REDLINE, Susan |
| description | There is increasing evidence that sleep-disordered breathing (SDB) is an independent risk factor for cardiovascular disease (CVD) in adults. C-reactive protein (CRP), a marker of systemic inflammation, is an important predictor of future cardiovascular events. The goal of this study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better understand the role of SDB in CVD risk.
Adolescents (n=143; age, 13 to 18 years; 36% black; 50% female) with a wide range of SDB severity underwent polysomnography and measurement of high-sensitivity CRP. SDB was quantified with the apnea hypopnea index (AHI) and oxygen desaturation measures. Sleep duration was estimated from 7-day actigraphy. The independent and dose-response associations of SDB with CRP were addressed through linear mixed-effects models. Forty-eight percent were overweight or obese, and 12% had SDB (AHI > or =5). CRP levels varied with increasing body mass index and SDB. After adjustment for body mass index , age, sex, and race, mean CRP levels were 0.50, 0.43, 0.97, and 1.66 mg/L for SDB severity levels of AHI or =15, respectively (P=0.0049, AHI > or =15 versus or =5 is associated with increasing levels of CRP, suggesting that pediatric SDB may confer additional CVD risk beyond that of obesity. |
| doi_str_mv | 10.1161/01.CIR.0000161819.76138.5E |
| format | Article |
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Adolescents (n=143; age, 13 to 18 years; 36% black; 50% female) with a wide range of SDB severity underwent polysomnography and measurement of high-sensitivity CRP. SDB was quantified with the apnea hypopnea index (AHI) and oxygen desaturation measures. Sleep duration was estimated from 7-day actigraphy. The independent and dose-response associations of SDB with CRP were addressed through linear mixed-effects models. Forty-eight percent were overweight or obese, and 12% had SDB (AHI > or =5). CRP levels varied with increasing body mass index and SDB. After adjustment for body mass index , age, sex, and race, mean CRP levels were 0.50, 0.43, 0.97, and 1.66 mg/L for SDB severity levels of AHI <1, 1 to 4.9, 5 to 14.9, and > or =15, respectively (P=0.0049, AHI > or =15 versus <1). Adjusted mean CRP levels demonstrated a dose response with SDB above a threshold AHI of 5. This association was partially explained by overnight hypoxemia and less so by sleep duration.
In adolescents free of known CVD, an AHI > or =5 is associated with increasing levels of CRP, suggesting that pediatric SDB may confer additional CVD risk beyond that of obesity.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000161819.76138.5E</identifier><identifier>PMID: 15837952</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Body Mass Index ; Body Weight ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cardiovascular Diseases - etiology ; Coronary heart disease ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Heart ; Humans ; Hypoxia ; Male ; Medical sciences ; Obesity ; Polysomnography ; Risk Factors ; Sleep Apnea Syndromes - blood ; Sleep Deprivation ; Time Factors</subject><ispartof>Circulation (New York, N.Y.), 2005-04, Vol.111 (15), p.1978-1984</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c333t-1471b31410aec8aa585c81a576bb34f7f08723e13c0d19580add6ac05d8b18273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16743168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15837952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LARKIN, Emma K</creatorcontrib><creatorcontrib>ROSEN, Carol L</creatorcontrib><creatorcontrib>KIRCHNER, H. Lester</creatorcontrib><creatorcontrib>STORFER-ISSER, Amy</creatorcontrib><creatorcontrib>EMANCIPATOR, Judith L</creatorcontrib><creatorcontrib>JOHNSON, Nathan L</creatorcontrib><creatorcontrib>ZAMBITO, Anna Marie V</creatorcontrib><creatorcontrib>TRACY, Russell P</creatorcontrib><creatorcontrib>JENNY, Nancy S</creatorcontrib><creatorcontrib>REDLINE, Susan</creatorcontrib><title>Variation of C-reactive protein levels in adolescents : Association with sleep-disordered breathing and sleep duration</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>There is increasing evidence that sleep-disordered breathing (SDB) is an independent risk factor for cardiovascular disease (CVD) in adults. C-reactive protein (CRP), a marker of systemic inflammation, is an important predictor of future cardiovascular events. The goal of this study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better understand the role of SDB in CVD risk.
Adolescents (n=143; age, 13 to 18 years; 36% black; 50% female) with a wide range of SDB severity underwent polysomnography and measurement of high-sensitivity CRP. SDB was quantified with the apnea hypopnea index (AHI) and oxygen desaturation measures. Sleep duration was estimated from 7-day actigraphy. The independent and dose-response associations of SDB with CRP were addressed through linear mixed-effects models. Forty-eight percent were overweight or obese, and 12% had SDB (AHI > or =5). CRP levels varied with increasing body mass index and SDB. After adjustment for body mass index , age, sex, and race, mean CRP levels were 0.50, 0.43, 0.97, and 1.66 mg/L for SDB severity levels of AHI <1, 1 to 4.9, 5 to 14.9, and > or =15, respectively (P=0.0049, AHI > or =15 versus <1). Adjusted mean CRP levels demonstrated a dose response with SDB above a threshold AHI of 5. This association was partially explained by overnight hypoxemia and less so by sleep duration.
In adolescents free of known CVD, an AHI > or =5 is associated with increasing levels of CRP, suggesting that pediatric SDB may confer additional CVD risk beyond that of obesity.</description><subject>Adolescent</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Coronary heart disease</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Obesity</subject><subject>Polysomnography</subject><subject>Risk Factors</subject><subject>Sleep Apnea Syndromes - blood</subject><subject>Sleep Deprivation</subject><subject>Time Factors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFFr2zAQx8XYWNNuX2GIwfpmT2dZlty3EtK1UBiUbq_iLJ1XDcfOJCej335aYohepEO__x33Y-wziBKgga8CyvXDUynyyaWBttQNSFOqzRu2AlXVRa1k-5atMtAWWlbVBbtM6XcuG6nVe3YBykjdqmrFDj8xBpzDNPKp5-siEro5HIjv4jRTGPlABxoSzy_000DJ0TgnfsNvU5rckvwb5heeBqJd4UOaoqdInne51_wSxl8cR3_65n4fj5EP7F2PQ6KPy33Fftxtntf3xeP3bw_r28fCSSnnAmoNnYQaBJIziMooZwCVbrpO1r3uhdGVJJBOeGiVEeh9g04obzowlZZX7PrUN6_zZ09pttuQVxgGHGnaJ9torUAewZsT6OKUUqTe7mLYYny1IOx_61aAzdbt2bo9Wrdqk8Oflin7bkv-HF00Z-DLAmByOPQRRxfSmWt0LaEx8h8pkox9</recordid><startdate>20050419</startdate><enddate>20050419</enddate><creator>LARKIN, Emma K</creator><creator>ROSEN, Carol L</creator><creator>KIRCHNER, H. Lester</creator><creator>STORFER-ISSER, Amy</creator><creator>EMANCIPATOR, Judith L</creator><creator>JOHNSON, Nathan L</creator><creator>ZAMBITO, Anna Marie V</creator><creator>TRACY, Russell P</creator><creator>JENNY, Nancy S</creator><creator>REDLINE, Susan</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050419</creationdate><title>Variation of C-reactive protein levels in adolescents : Association with sleep-disordered breathing and sleep duration</title><author>LARKIN, Emma K ; ROSEN, Carol L ; KIRCHNER, H. Lester ; STORFER-ISSER, Amy ; EMANCIPATOR, Judith L ; JOHNSON, Nathan L ; ZAMBITO, Anna Marie V ; TRACY, Russell P ; JENNY, Nancy S ; REDLINE, Susan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-1471b31410aec8aa585c81a576bb34f7f08723e13c0d19580add6ac05d8b18273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Coronary heart disease</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Obesity</topic><topic>Polysomnography</topic><topic>Risk Factors</topic><topic>Sleep Apnea Syndromes - blood</topic><topic>Sleep Deprivation</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LARKIN, Emma K</creatorcontrib><creatorcontrib>ROSEN, Carol L</creatorcontrib><creatorcontrib>KIRCHNER, H. Lester</creatorcontrib><creatorcontrib>STORFER-ISSER, Amy</creatorcontrib><creatorcontrib>EMANCIPATOR, Judith L</creatorcontrib><creatorcontrib>JOHNSON, Nathan L</creatorcontrib><creatorcontrib>ZAMBITO, Anna Marie V</creatorcontrib><creatorcontrib>TRACY, Russell P</creatorcontrib><creatorcontrib>JENNY, Nancy S</creatorcontrib><creatorcontrib>REDLINE, Susan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LARKIN, Emma K</au><au>ROSEN, Carol L</au><au>KIRCHNER, H. Lester</au><au>STORFER-ISSER, Amy</au><au>EMANCIPATOR, Judith L</au><au>JOHNSON, Nathan L</au><au>ZAMBITO, Anna Marie V</au><au>TRACY, Russell P</au><au>JENNY, Nancy S</au><au>REDLINE, Susan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variation of C-reactive protein levels in adolescents : Association with sleep-disordered breathing and sleep duration</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2005-04-19</date><risdate>2005</risdate><volume>111</volume><issue>15</issue><spage>1978</spage><epage>1984</epage><pages>1978-1984</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>There is increasing evidence that sleep-disordered breathing (SDB) is an independent risk factor for cardiovascular disease (CVD) in adults. C-reactive protein (CRP), a marker of systemic inflammation, is an important predictor of future cardiovascular events. The goal of this study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better understand the role of SDB in CVD risk.
Adolescents (n=143; age, 13 to 18 years; 36% black; 50% female) with a wide range of SDB severity underwent polysomnography and measurement of high-sensitivity CRP. SDB was quantified with the apnea hypopnea index (AHI) and oxygen desaturation measures. Sleep duration was estimated from 7-day actigraphy. The independent and dose-response associations of SDB with CRP were addressed through linear mixed-effects models. Forty-eight percent were overweight or obese, and 12% had SDB (AHI > or =5). CRP levels varied with increasing body mass index and SDB. After adjustment for body mass index , age, sex, and race, mean CRP levels were 0.50, 0.43, 0.97, and 1.66 mg/L for SDB severity levels of AHI <1, 1 to 4.9, 5 to 14.9, and > or =15, respectively (P=0.0049, AHI > or =15 versus <1). Adjusted mean CRP levels demonstrated a dose response with SDB above a threshold AHI of 5. This association was partially explained by overnight hypoxemia and less so by sleep duration.
In adolescents free of known CVD, an AHI > or =5 is associated with increasing levels of CRP, suggesting that pediatric SDB may confer additional CVD risk beyond that of obesity.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15837952</pmid><doi>10.1161/01.CIR.0000161819.76138.5E</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Body Mass Index Body Weight C-Reactive Protein - analysis Cardiology. Vascular system Cardiovascular Diseases - etiology Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Heart Humans Hypoxia Male Medical sciences Obesity Polysomnography Risk Factors Sleep Apnea Syndromes - blood Sleep Deprivation Time Factors |
| title | Variation of C-reactive protein levels in adolescents : Association with sleep-disordered breathing and sleep duration |
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