Expression and distribution of aquaporin-1 in nasal polyps: does it have any significance in edema formation?
The aim of this study was to investigate the expression of Aquaporin 1 (AQP1) and AQP4 in polyp tissue. Nasal polyps were obtained from 34 patients with nasal polyposis during endoscopic sinus surgery. Bullous middle turbinates with normal-appearing mucosa of 10 patients were used as controls. Expre...
Gespeichert in:
| Veröffentlicht in: | American journal of rhinology 2006-01, Vol.20 (1), p.128-131 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 131 |
|---|---|
| container_issue | 1 |
| container_start_page | 128 |
| container_title | American journal of rhinology |
| container_volume | 20 |
| creator | Altuntas, Ali Yilmaz, Mustafa Deniz Aktepe, Fatma Kahveci, Orhan Kemal Derekoy, Sefa Dilek, Hüsniye Serteser, Mustafa |
| description | The aim of this study was to investigate the expression of Aquaporin 1 (AQP1) and AQP4 in polyp tissue.
Nasal polyps were obtained from 34 patients with nasal polyposis during endoscopic sinus surgery. Bullous middle turbinates with normal-appearing mucosa of 10 patients were used as controls. Expression of AQP1 and AQP4 water channels were determined by immunohistochemical methods.
AQP1 has been found to be expressed in fibroblasts located in polyp tissue, especially in the subepithelial area, periphery of seromucous glands, and endothelial cells of venules.
We have established a high expression of AQP1 water channels in nasal polyp tissue and have suggested two mechanisms to explain this finding. Increased AQP1 expression may be a cause or a consequence of edema formation. Thus, additional studies are needed to elucidate the true mechanism underlying this relationship. |
| doi_str_mv | 10.1177/194589240602000124 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67750784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67750784</sourcerecordid><originalsourceid>FETCH-LOGICAL-c328t-f4a1c951043fa739c3c707ee0d5e4f601b9650e51c879b1341e7f0737102a3023</originalsourceid><addsrcrecordid>eNplkUFrFjEQhoMotlb_gAcJHrytziSbZONFSqmtUPCi5yVfdqIpu8k22RW_f-8u_UDQ0wzD8z4MM4y9RniPaMwHtK3qrGhBgwAAFO0Tdo5K2kYLC0-3HhQ0WnX6jL2o9X5DjOjwOTtDvVES7Dmbrn_PhWqNOXGXBj7EupR4WJd9kAN3D6ubc4mpQR4TT666kc95PM71Ix8yVR4X_tP9oi195DX-SDFE75KnHaeBJsdDLpPbhZ9esmfBjZVeneoF-_75-tvVbXP39ebL1eVd46Xolia0Dr1VCK0MzkjrpTdgiGBQ1AYNeLBaASn0nbEHlC2SCWCkQRBOgpAX7N2jdy75YaW69FOsnsbRJcpr7bUxCkzXbuDbf8D7vJa07dYLCR0YLXebeIR8ybUWCv1c4uTKsUfo90_0_39iC705mdfDRMPfyOn08g-1pYJW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230807632</pqid></control><display><type>article</type><title>Expression and distribution of aquaporin-1 in nasal polyps: does it have any significance in edema formation?</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Altuntas, Ali ; Yilmaz, Mustafa Deniz ; Aktepe, Fatma ; Kahveci, Orhan Kemal ; Derekoy, Sefa ; Dilek, Hüsniye ; Serteser, Mustafa</creator><creatorcontrib>Altuntas, Ali ; Yilmaz, Mustafa Deniz ; Aktepe, Fatma ; Kahveci, Orhan Kemal ; Derekoy, Sefa ; Dilek, Hüsniye ; Serteser, Mustafa</creatorcontrib><description>The aim of this study was to investigate the expression of Aquaporin 1 (AQP1) and AQP4 in polyp tissue.
Nasal polyps were obtained from 34 patients with nasal polyposis during endoscopic sinus surgery. Bullous middle turbinates with normal-appearing mucosa of 10 patients were used as controls. Expression of AQP1 and AQP4 water channels were determined by immunohistochemical methods.
AQP1 has been found to be expressed in fibroblasts located in polyp tissue, especially in the subepithelial area, periphery of seromucous glands, and endothelial cells of venules.
We have established a high expression of AQP1 water channels in nasal polyp tissue and have suggested two mechanisms to explain this finding. Increased AQP1 expression may be a cause or a consequence of edema formation. Thus, additional studies are needed to elucidate the true mechanism underlying this relationship.</description><identifier>ISSN: 1050-6586</identifier><identifier>ISSN: 1945-8924</identifier><identifier>EISSN: 1539-6290</identifier><identifier>EISSN: 1945-8932</identifier><identifier>DOI: 10.1177/194589240602000124</identifier><identifier>PMID: 16539309</identifier><language>eng</language><publisher>United States: SAGE PUBLICATIONS, INC</publisher><subject>Aquaporin 1 - analysis ; Aquaporin 1 - biosynthesis ; Aquaporin 4 - analysis ; Aquaporin 4 - biosynthesis ; Capillary Permeability ; Edema - etiology ; Edema - metabolism ; Edema - pathology ; Endoscopy ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - pathology ; Fibroblasts - metabolism ; Humans ; Immunohistochemistry ; Multivariate Analysis ; Nasal Polyps - etiology ; Nasal Polyps - metabolism ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - pathology ; Tomography, X-Ray Computed</subject><ispartof>American journal of rhinology, 2006-01, Vol.20 (1), p.128-131</ispartof><rights>Copyright OceanSide Publications Jan 1, 2006</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-f4a1c951043fa739c3c707ee0d5e4f601b9650e51c879b1341e7f0737102a3023</citedby><cites>FETCH-LOGICAL-c328t-f4a1c951043fa739c3c707ee0d5e4f601b9650e51c879b1341e7f0737102a3023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16539309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altuntas, Ali</creatorcontrib><creatorcontrib>Yilmaz, Mustafa Deniz</creatorcontrib><creatorcontrib>Aktepe, Fatma</creatorcontrib><creatorcontrib>Kahveci, Orhan Kemal</creatorcontrib><creatorcontrib>Derekoy, Sefa</creatorcontrib><creatorcontrib>Dilek, Hüsniye</creatorcontrib><creatorcontrib>Serteser, Mustafa</creatorcontrib><title>Expression and distribution of aquaporin-1 in nasal polyps: does it have any significance in edema formation?</title><title>American journal of rhinology</title><addtitle>Am J Rhinol</addtitle><description>The aim of this study was to investigate the expression of Aquaporin 1 (AQP1) and AQP4 in polyp tissue.
Nasal polyps were obtained from 34 patients with nasal polyposis during endoscopic sinus surgery. Bullous middle turbinates with normal-appearing mucosa of 10 patients were used as controls. Expression of AQP1 and AQP4 water channels were determined by immunohistochemical methods.
AQP1 has been found to be expressed in fibroblasts located in polyp tissue, especially in the subepithelial area, periphery of seromucous glands, and endothelial cells of venules.
We have established a high expression of AQP1 water channels in nasal polyp tissue and have suggested two mechanisms to explain this finding. Increased AQP1 expression may be a cause or a consequence of edema formation. Thus, additional studies are needed to elucidate the true mechanism underlying this relationship.</description><subject>Aquaporin 1 - analysis</subject><subject>Aquaporin 1 - biosynthesis</subject><subject>Aquaporin 4 - analysis</subject><subject>Aquaporin 4 - biosynthesis</subject><subject>Capillary Permeability</subject><subject>Edema - etiology</subject><subject>Edema - metabolism</subject><subject>Edema - pathology</subject><subject>Endoscopy</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - pathology</subject><subject>Fibroblasts - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Multivariate Analysis</subject><subject>Nasal Polyps - etiology</subject><subject>Nasal Polyps - metabolism</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Tomography, X-Ray Computed</subject><issn>1050-6586</issn><issn>1945-8924</issn><issn>1539-6290</issn><issn>1945-8932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNplkUFrFjEQhoMotlb_gAcJHrytziSbZONFSqmtUPCi5yVfdqIpu8k22RW_f-8u_UDQ0wzD8z4MM4y9RniPaMwHtK3qrGhBgwAAFO0Tdo5K2kYLC0-3HhQ0WnX6jL2o9X5DjOjwOTtDvVES7Dmbrn_PhWqNOXGXBj7EupR4WJd9kAN3D6ubc4mpQR4TT666kc95PM71Ix8yVR4X_tP9oi195DX-SDFE75KnHaeBJsdDLpPbhZ9esmfBjZVeneoF-_75-tvVbXP39ebL1eVd46Xolia0Dr1VCK0MzkjrpTdgiGBQ1AYNeLBaASn0nbEHlC2SCWCkQRBOgpAX7N2jdy75YaW69FOsnsbRJcpr7bUxCkzXbuDbf8D7vJa07dYLCR0YLXebeIR8ybUWCv1c4uTKsUfo90_0_39iC705mdfDRMPfyOn08g-1pYJW</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Altuntas, Ali</creator><creator>Yilmaz, Mustafa Deniz</creator><creator>Aktepe, Fatma</creator><creator>Kahveci, Orhan Kemal</creator><creator>Derekoy, Sefa</creator><creator>Dilek, Hüsniye</creator><creator>Serteser, Mustafa</creator><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Expression and distribution of aquaporin-1 in nasal polyps: does it have any significance in edema formation?</title><author>Altuntas, Ali ; Yilmaz, Mustafa Deniz ; Aktepe, Fatma ; Kahveci, Orhan Kemal ; Derekoy, Sefa ; Dilek, Hüsniye ; Serteser, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-f4a1c951043fa739c3c707ee0d5e4f601b9650e51c879b1341e7f0737102a3023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aquaporin 1 - analysis</topic><topic>Aquaporin 1 - biosynthesis</topic><topic>Aquaporin 4 - analysis</topic><topic>Aquaporin 4 - biosynthesis</topic><topic>Capillary Permeability</topic><topic>Edema - etiology</topic><topic>Edema - metabolism</topic><topic>Edema - pathology</topic><topic>Endoscopy</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - pathology</topic><topic>Fibroblasts - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Multivariate Analysis</topic><topic>Nasal Polyps - etiology</topic><topic>Nasal Polyps - metabolism</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>online_resources</toplevel><creatorcontrib>Altuntas, Ali</creatorcontrib><creatorcontrib>Yilmaz, Mustafa Deniz</creatorcontrib><creatorcontrib>Aktepe, Fatma</creatorcontrib><creatorcontrib>Kahveci, Orhan Kemal</creatorcontrib><creatorcontrib>Derekoy, Sefa</creatorcontrib><creatorcontrib>Dilek, Hüsniye</creatorcontrib><creatorcontrib>Serteser, Mustafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altuntas, Ali</au><au>Yilmaz, Mustafa Deniz</au><au>Aktepe, Fatma</au><au>Kahveci, Orhan Kemal</au><au>Derekoy, Sefa</au><au>Dilek, Hüsniye</au><au>Serteser, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression and distribution of aquaporin-1 in nasal polyps: does it have any significance in edema formation?</atitle><jtitle>American journal of rhinology</jtitle><addtitle>Am J Rhinol</addtitle><date>2006-01</date><risdate>2006</risdate><volume>20</volume><issue>1</issue><spage>128</spage><epage>131</epage><pages>128-131</pages><issn>1050-6586</issn><issn>1945-8924</issn><eissn>1539-6290</eissn><eissn>1945-8932</eissn><abstract>The aim of this study was to investigate the expression of Aquaporin 1 (AQP1) and AQP4 in polyp tissue.
Nasal polyps were obtained from 34 patients with nasal polyposis during endoscopic sinus surgery. Bullous middle turbinates with normal-appearing mucosa of 10 patients were used as controls. Expression of AQP1 and AQP4 water channels were determined by immunohistochemical methods.
AQP1 has been found to be expressed in fibroblasts located in polyp tissue, especially in the subepithelial area, periphery of seromucous glands, and endothelial cells of venules.
We have established a high expression of AQP1 water channels in nasal polyp tissue and have suggested two mechanisms to explain this finding. Increased AQP1 expression may be a cause or a consequence of edema formation. Thus, additional studies are needed to elucidate the true mechanism underlying this relationship.</abstract><cop>United States</cop><pub>SAGE PUBLICATIONS, INC</pub><pmid>16539309</pmid><doi>10.1177/194589240602000124</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1050-6586 |
| ispartof | American journal of rhinology, 2006-01, Vol.20 (1), p.128-131 |
| issn | 1050-6586 1945-8924 1539-6290 1945-8932 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67750784 |
| source | Access via SAGE; MEDLINE |
| subjects | Aquaporin 1 - analysis Aquaporin 1 - biosynthesis Aquaporin 4 - analysis Aquaporin 4 - biosynthesis Capillary Permeability Edema - etiology Edema - metabolism Edema - pathology Endoscopy Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Fibroblasts - metabolism Humans Immunohistochemistry Multivariate Analysis Nasal Polyps - etiology Nasal Polyps - metabolism Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Tomography, X-Ray Computed |
| title | Expression and distribution of aquaporin-1 in nasal polyps: does it have any significance in edema formation? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T02%3A47%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20and%20distribution%20of%20aquaporin-1%20in%20nasal%20polyps:%20does%20it%20have%20any%20significance%20in%20edema%20formation?&rft.jtitle=American%20journal%20of%20rhinology&rft.au=Altuntas,%20Ali&rft.date=2006-01&rft.volume=20&rft.issue=1&rft.spage=128&rft.epage=131&rft.pages=128-131&rft.issn=1050-6586&rft.eissn=1539-6290&rft_id=info:doi/10.1177/194589240602000124&rft_dat=%3Cproquest_cross%3E67750784%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=230807632&rft_id=info:pmid/16539309&rfr_iscdi=true |