Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases

Matrix metalloproteinases (MMPs) are endopeptidases that play pivotal roles in promoting tumor disease progression, including tumor angiogenesis. In many solid tumors, MMP expression could be attributed to tumor stromal cells and is partially regulated by tumor-stroma interactions via tumor cell-ass...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-04, Vol.65 (8), p.3193-3199
Hauptverfasser:	YI TANG, NAKADA, Marian T, KESAVAN, Prabakaran, MCCABE, Francis, MILLAR, Hillary, RAFFERTY, Patricia, BUGELSKI, Peter, LI YAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - biosynthesis Antigens, CD - genetics Antigens, CD - physiology Antineoplastic agents Basigin Biological and medical sciences Breast Neoplasms - blood supply Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Growth Processes - physiology Cell Line, Tumor Cell Movement - physiology Coculture Techniques Endothelial Cells - cytology Female Fibroblasts - cytology Humans Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Medical sciences Mice Mice, Nude Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pharmacology. Drug treatments Transplantation, Heterologous Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - biosynthesis
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