Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic rats

The present study investigated the effect of agmatine, an endogenous ligand of imidazoline receptors, on plasma glucose in streptozotocin-induced diabetic rats (STZ-diabetic rats). Plasma glucose was assessed by the glucose oxidase method. Plasma insulin and beta-endorphin-like immunoreactivity in p...

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Veröffentlicht in:	Diabetologia 2005-04, Vol.48 (4), p.767-775
Hauptverfasser:	HWANG, S.-L, LIU, I.-M, TZENG, T.-F, CHENG, J.-T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenal Medulla - drug effects Adrenal Medulla - metabolism Adrenalectomy Agmatine - administration & dosage Agmatine - pharmacology Animals beta-Endorphin - blood Biological and medical sciences Blood Glucose - metabolism Blood Pressure - drug effects Clonidine - pharmacology Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gene Expression - drug effects Glucose Transporter Type 4 Imidazoles - pharmacology Imidazoline Receptors Male Medical sciences Monosaccharide Transport Proteins - genetics Muscle Proteins - genetics Phosphoenolpyruvate Carboxykinase (GTP) - genetics Rats Rats, Wistar Receptors, Drug - agonists Receptors, Drug - antagonists & inhibitors Receptors, Opioid, mu - antagonists & inhibitors
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