Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck
Purpose: Recently, the kinase domain mutations of epidermal growth factor receptor ( EGFR ) gene have been identified in non–small-cell lung cancer, and these mutations have been related to the clinical response to the tyrosine kinase inhibitor gefitinib. Gefitinib treatment has also shown clinical...
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| Veröffentlicht in: | Clinical cancer research 2005-04, Vol.11 (8), p.2879-2882 |
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| container_title | Clinical cancer research |
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| creator | Lee, Jong Woo Soung, Young Hwa Kim, Su Young Nam, Hyo Kyung Park, Won Sang Nam, Suk Woo Kim, Min Sik Sun, Dong Il Lee, Youn Soo Jang, Ja June Lee, Jung Young Yoo, Nam Jin Lee, Sug Hyung |
| description | Purpose: Recently, the kinase domain mutations of epidermal growth factor receptor ( EGFR ) gene have been identified in non–small-cell lung cancer, and these mutations have been related to the clinical response
to the tyrosine kinase inhibitor gefitinib. Gefitinib treatment has also shown clinical benefits in squamous cell carcinoma
of the head and neck (SCCHN). The aim of this study was to explore the possibility that SCCHN harbored the EGFR mutations.
Experimental Design: In this study, we analyzed EGFR gene in 41 SCCHN for the detection of the somatic mutations by PCR-single-strand conformational polymorphism analysis.
Results: Overall, we detected three EGFR mutations (7.3%), and all of the mutations were the same in-frame deletion mutation in exon 19 (E746_A750del).
Conclusion: These data indicated that in addition to non–small-cell lung cancer, SCCHN harbors the EGFR gene mutations, and suggested the rationale for the clinical applicability of gefinitib to SCCHN patients. |
| doi_str_mv | 10.1158/1078-0432.CCR-04-2029 |
| format | Article |
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to the tyrosine kinase inhibitor gefitinib. Gefitinib treatment has also shown clinical benefits in squamous cell carcinoma
of the head and neck (SCCHN). The aim of this study was to explore the possibility that SCCHN harbored the EGFR mutations.
Experimental Design: In this study, we analyzed EGFR gene in 41 SCCHN for the detection of the somatic mutations by PCR-single-strand conformational polymorphism analysis.
Results: Overall, we detected three EGFR mutations (7.3%), and all of the mutations were the same in-frame deletion mutation in exon 19 (E746_A750del).
Conclusion: These data indicated that in addition to non–small-cell lung cancer, SCCHN harbors the EGFR gene mutations, and suggested the rationale for the clinical applicability of gefinitib to SCCHN patients.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-04-2029</identifier><identifier>PMID: 15837736</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Base Sequence ; Biological and medical sciences ; Carcinoma, Squamous Cell - genetics ; DNA Mutational Analysis ; DNA, Neoplasm - chemistry ; DNA, Neoplasm - genetics ; EGFR ; Female ; gefitinib ; head and neck cancer ; Head and Neck Neoplasms - genetics ; Humans ; Iressa ; Male ; Medical sciences ; Middle Aged ; Mutation ; oncogene ; Pharmacology. Drug treatments ; Polymorphism, Single-Stranded Conformational ; Receptor, Epidermal Growth Factor - genetics</subject><ispartof>Clinical cancer research, 2005-04, Vol.11 (8), p.2879-2882</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-7721a71a2110893720280d94588633d67457a9dc7b77c2045b5630bbcd425e843</citedby><cites>FETCH-LOGICAL-c467t-7721a71a2110893720280d94588633d67457a9dc7b77c2045b5630bbcd425e843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16706953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15837736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jong Woo</creatorcontrib><creatorcontrib>Soung, Young Hwa</creatorcontrib><creatorcontrib>Kim, Su Young</creatorcontrib><creatorcontrib>Nam, Hyo Kyung</creatorcontrib><creatorcontrib>Park, Won Sang</creatorcontrib><creatorcontrib>Nam, Suk Woo</creatorcontrib><creatorcontrib>Kim, Min Sik</creatorcontrib><creatorcontrib>Sun, Dong Il</creatorcontrib><creatorcontrib>Lee, Youn Soo</creatorcontrib><creatorcontrib>Jang, Ja June</creatorcontrib><creatorcontrib>Lee, Jung Young</creatorcontrib><creatorcontrib>Yoo, Nam Jin</creatorcontrib><creatorcontrib>Lee, Sug Hyung</creatorcontrib><title>Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: Recently, the kinase domain mutations of epidermal growth factor receptor ( EGFR ) gene have been identified in non–small-cell lung cancer, and these mutations have been related to the clinical response
to the tyrosine kinase inhibitor gefitinib. Gefitinib treatment has also shown clinical benefits in squamous cell carcinoma
of the head and neck (SCCHN). The aim of this study was to explore the possibility that SCCHN harbored the EGFR mutations.
Experimental Design: In this study, we analyzed EGFR gene in 41 SCCHN for the detection of the somatic mutations by PCR-single-strand conformational polymorphism analysis.
Results: Overall, we detected three EGFR mutations (7.3%), and all of the mutations were the same in-frame deletion mutation in exon 19 (E746_A750del).
Conclusion: These data indicated that in addition to non–small-cell lung cancer, SCCHN harbors the EGFR gene mutations, and suggested the rationale for the clinical applicability of gefinitib to SCCHN patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>DNA Mutational Analysis</subject><subject>DNA, Neoplasm - chemistry</subject><subject>DNA, Neoplasm - genetics</subject><subject>EGFR</subject><subject>Female</subject><subject>gefitinib</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Humans</subject><subject>Iressa</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>oncogene</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymorphism, Single-Stranded Conformational</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq0KVOiWn9DKF1AvWfw9zrGKlgWJDwnK2XIcbzftJgE7UdV_34l2EceeZg7PO_PqIeQLZ0vOtb3kDGzBlBTLqnrEpRBMlB_IKdcaCimMPsL9jTkhn3L-xRhXnKmP5AQPSABpTsn909D5sQ30bhpxDn2mw4au1lePdB37SNuePr1OvhumTKu429HKp9D2GJq5cRvpdfQN9X1D72P4_Zkcb_wux7PDXJDnq9WP6rq4fVjfVN9vi6AMjAWA4B64F5wzW0rA7pY1pdLWGikbA0qDL5sANUAQTOlaG8nqOjRK6GiVXJCL_d2XNLxOMY-ua3PAfr6PWNUZAFUCL_8LcpCKAzAE9R4Macg5xY17SW3n01_HmZuNu9mmm206NI6Lm41j7uvhwVR3sXlPHRQjcH4AfA5-t0m-D21-5wwwU2qJ3Lc9t21_bv-0KbqAZEwp5ojOt1jCWScslPIfDICTKg</recordid><startdate>20050415</startdate><enddate>20050415</enddate><creator>Lee, Jong Woo</creator><creator>Soung, Young Hwa</creator><creator>Kim, Su Young</creator><creator>Nam, Hyo Kyung</creator><creator>Park, Won Sang</creator><creator>Nam, Suk Woo</creator><creator>Kim, Min Sik</creator><creator>Sun, Dong Il</creator><creator>Lee, Youn Soo</creator><creator>Jang, Ja June</creator><creator>Lee, Jung Young</creator><creator>Yoo, Nam Jin</creator><creator>Lee, Sug Hyung</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050415</creationdate><title>Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck</title><author>Lee, Jong Woo ; Soung, Young Hwa ; Kim, Su Young ; Nam, Hyo Kyung ; Park, Won Sang ; Nam, Suk Woo ; Kim, Min Sik ; Sun, Dong Il ; Lee, Youn Soo ; Jang, Ja June ; Lee, Jung Young ; Yoo, Nam Jin ; Lee, Sug Hyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-7721a71a2110893720280d94588633d67457a9dc7b77c2045b5630bbcd425e843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>DNA Mutational Analysis</topic><topic>DNA, Neoplasm - chemistry</topic><topic>DNA, Neoplasm - genetics</topic><topic>EGFR</topic><topic>Female</topic><topic>gefitinib</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Humans</topic><topic>Iressa</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>oncogene</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymorphism, Single-Stranded Conformational</topic><topic>Receptor, Epidermal Growth Factor - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jong Woo</creatorcontrib><creatorcontrib>Soung, Young Hwa</creatorcontrib><creatorcontrib>Kim, Su Young</creatorcontrib><creatorcontrib>Nam, Hyo Kyung</creatorcontrib><creatorcontrib>Park, Won Sang</creatorcontrib><creatorcontrib>Nam, Suk Woo</creatorcontrib><creatorcontrib>Kim, Min Sik</creatorcontrib><creatorcontrib>Sun, Dong Il</creatorcontrib><creatorcontrib>Lee, Youn Soo</creatorcontrib><creatorcontrib>Jang, Ja June</creatorcontrib><creatorcontrib>Lee, Jung Young</creatorcontrib><creatorcontrib>Yoo, Nam Jin</creatorcontrib><creatorcontrib>Lee, Sug Hyung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jong Woo</au><au>Soung, Young Hwa</au><au>Kim, Su Young</au><au>Nam, Hyo Kyung</au><au>Park, Won Sang</au><au>Nam, Suk Woo</au><au>Kim, Min Sik</au><au>Sun, Dong Il</au><au>Lee, Youn Soo</au><au>Jang, Ja June</au><au>Lee, Jung Young</au><au>Yoo, Nam Jin</au><au>Lee, Sug Hyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2005-04-15</date><risdate>2005</risdate><volume>11</volume><issue>8</issue><spage>2879</spage><epage>2882</epage><pages>2879-2882</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: Recently, the kinase domain mutations of epidermal growth factor receptor ( EGFR ) gene have been identified in non–small-cell lung cancer, and these mutations have been related to the clinical response
to the tyrosine kinase inhibitor gefitinib. Gefitinib treatment has also shown clinical benefits in squamous cell carcinoma
of the head and neck (SCCHN). The aim of this study was to explore the possibility that SCCHN harbored the EGFR mutations.
Experimental Design: In this study, we analyzed EGFR gene in 41 SCCHN for the detection of the somatic mutations by PCR-single-strand conformational polymorphism analysis.
Results: Overall, we detected three EGFR mutations (7.3%), and all of the mutations were the same in-frame deletion mutation in exon 19 (E746_A750del).
Conclusion: These data indicated that in addition to non–small-cell lung cancer, SCCHN harbors the EGFR gene mutations, and suggested the rationale for the clinical applicability of gefinitib to SCCHN patients.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15837736</pmid><doi>10.1158/1078-0432.CCR-04-2029</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Antineoplastic agents Base Sequence Biological and medical sciences Carcinoma, Squamous Cell - genetics DNA Mutational Analysis DNA, Neoplasm - chemistry DNA, Neoplasm - genetics EGFR Female gefitinib head and neck cancer Head and Neck Neoplasms - genetics Humans Iressa Male Medical sciences Middle Aged Mutation oncogene Pharmacology. Drug treatments Polymorphism, Single-Stranded Conformational Receptor, Epidermal Growth Factor - genetics |
| title | Somatic Mutations of EGFR Gene in Squamous Cell Carcinoma of the Head and Neck |
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