Synthesis and in Vitro Evaluation of Biotinylated RG108: A High Affinity Compound for Studying Binding Interactions with Human DNA Methyltransferases

Small-molecule inhibitors of DNA methyltransferases such as RG108 represent promising candidates for cancer drug development. We report the synthesis and in vitro analysis of a biotinylated RG108 conjugate, 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(5-{3-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-y...

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Veröffentlicht in:	Bioconjugate chemistry 2006-03, Vol.17 (2), p.261-266
Hauptverfasser:	Schirrmacher, Esther, Beck, Carmen, Brueckner, Bodo, Schmitges, Frank, Siedlecki, Pawel, Bartenstein, Peter, Lyko, Frank, Schirrmacher, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biotin - chemistry Biotin - metabolism Cell-Free System Deoxyribonucleic acid DNA DNA Modification Methylases - antagonists & inhibitors DNA Modification Methylases - metabolism Enzymes Human body Humans Indoles - chemistry Indoles - metabolism Medical research Molecular Structure Nuclear Magnetic Resonance, Biomolecular Phthalimides Prescription drugs Propionates - chemistry Propionates - metabolism Protein Binding Proteins Tryptophan - analogs & derivatives
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