Retymicin, Galtamycin B, Saquayamycin Z and Ribofuranosyllumichrome, Novel Secondary Metabolites from Micromonospora sp. Tü 6368: I. Taxonomy, Fermentation, Isolation and Biological Activities
A new xanthone compound named retymicin ( 1 ) was isolated together with galtamycin B ( 2 ) and saquayamycin Z ( 3 ), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(α-ribofuranosyl)-lumichrome ( 4 ) from Micromonospora strain Tü 6368, isol...
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| Veröffentlicht in: | Journal of antibiotics 2005-02, Vol.58 (2), p.95-102 |
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| container_title | Journal of antibiotics |
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| creator | Antal, Noémi Fiedler, Hans-Peter Stackebrandt, Erko Beil, Winfried Ströch, Karsten Zeeck, Axel |
| description | A new xanthone compound named retymicin (
1
) was isolated together with galtamycin B (
2
) and saquayamycin Z (
3
), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(α-ribofuranosyl)-lumichrome (
4
) from
Micromonospora
strain Tü 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria. |
| doi_str_mv | 10.1038/ja.2005.12 |
| format | Article |
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1
) was isolated together with galtamycin B (
2
) and saquayamycin Z (
3
), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(α-ribofuranosyl)-lumichrome (
4
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1
) was isolated together with galtamycin B (
2
) and saquayamycin Z (
3
), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(α-ribofuranosyl)-lumichrome (
4
) from
Micromonospora
strain Tü 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.</description><subject>Anthracyclines - isolation & purification</subject><subject>Anthracyclines - pharmacology</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics, Antineoplastic - isolation & purification</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Carbohydrate Sequence</subject><subject>Cell Line, Tumor</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Fermentation</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Micromonospora - chemistry</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molecular Sequence Data</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Romania</subject><subject>Soil Microbiology</subject><subject>Xanthones - isolation & purification</subject><subject>Xanthones - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9O3DAQxi0Egi3lwgMgnzi0m-3YTmLnCKillYBKQC9cLDuZQFZJvNgJUo68F7e-GF7tSlw4zb_ffJr5CDlmsGAg1I-lWXCAbMH4DpkxpVjC0rzYJTMAzhKlOByQLyEsAYQUUu2TA5YpkUnOZuT1Foepa8qmn9NL0w6mm2JOz-f0zjyPZtrWD9T0Fb1trKtHb3oXprYd49qTdx3O6Y17wZbeYen6yviJXuNgrGubAQOtI0KvmzIGFxdXzhsaVgt6__-N5iJXX8lebdqAR9t4SP79-nl_8Tu5-nv55-LsKikFFENiecoKhJJhAbYsKmEqmVayAF5ZW0OhZFnbmtepBJFmBqySuc2zNLaFQZTikJxudFfePY8YBt01ocS2NT26MehcyrTgfA1-24Dx5BA81nrlmy6-pRnoteF6afTacM14hE-2qqPtsPpAtw5H4PsGCHHUP6LXSzf6Pn76mdw7fkeL4g</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Antal, Noémi</creator><creator>Fiedler, Hans-Peter</creator><creator>Stackebrandt, Erko</creator><creator>Beil, Winfried</creator><creator>Ströch, Karsten</creator><creator>Zeeck, Axel</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Retymicin, Galtamycin B, Saquayamycin Z and Ribofuranosyllumichrome, Novel Secondary Metabolites from Micromonospora sp. Tü 6368</title><author>Antal, Noémi ; Fiedler, Hans-Peter ; Stackebrandt, Erko ; Beil, Winfried ; Ströch, Karsten ; Zeeck, Axel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-b2419e0c1e90bc9d3ad74d7902dbbf0987cfbf2f470345a0b876b6547cf3aee73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anthracyclines - isolation & purification</topic><topic>Anthracyclines - pharmacology</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics, Antineoplastic - isolation & purification</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Bacteria - drug effects</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Carbohydrate Sequence</topic><topic>Cell Line, Tumor</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Fermentation</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Micromonospora - chemistry</topic><topic>Microscopy, Electron, Scanning</topic><topic>Molecular Sequence Data</topic><topic>Organic Chemistry</topic><topic>original-article</topic><topic>Romania</topic><topic>Soil Microbiology</topic><topic>Xanthones - isolation & purification</topic><topic>Xanthones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antal, Noémi</creatorcontrib><creatorcontrib>Fiedler, Hans-Peter</creatorcontrib><creatorcontrib>Stackebrandt, Erko</creatorcontrib><creatorcontrib>Beil, Winfried</creatorcontrib><creatorcontrib>Ströch, Karsten</creatorcontrib><creatorcontrib>Zeeck, Axel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antal, Noémi</au><au>Fiedler, Hans-Peter</au><au>Stackebrandt, Erko</au><au>Beil, Winfried</au><au>Ströch, Karsten</au><au>Zeeck, Axel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retymicin, Galtamycin B, Saquayamycin Z and Ribofuranosyllumichrome, Novel Secondary Metabolites from Micromonospora sp. 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1
) was isolated together with galtamycin B (
2
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3
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4
) from
Micromonospora
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anthracyclines - isolation & purification Anthracyclines - pharmacology Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Bacteria - drug effects Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Carbohydrate Sequence Cell Line, Tumor Chemical Phenomena Chemistry, Physical Chromatography, High Pressure Liquid Drug Screening Assays, Antitumor Fermentation Humans Life Sciences Medicinal Chemistry Microbial Sensitivity Tests Microbiology Micromonospora - chemistry Microscopy, Electron, Scanning Molecular Sequence Data Organic Chemistry original-article Romania Soil Microbiology Xanthones - isolation & purification Xanthones - pharmacology |
| title | Retymicin, Galtamycin B, Saquayamycin Z and Ribofuranosyllumichrome, Novel Secondary Metabolites from Micromonospora sp. Tü 6368: I. Taxonomy, Fermentation, Isolation and Biological Activities |
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