Clonostachysins A and B, New Anti-dinoflagellate Cyclic Peptides from a Marine-derived Fungus
The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus Clonostachys rogersoniana strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereoch...
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| Veröffentlicht in: | Journal of antibiotics 2005-02, Vol.58 (2), p.145-150 |
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| creator | Adachi, Kyoko Kanoh, Kaneo Wisespongp, Puntip Nishijima, Miyuki Shizuri, Yoshikazu |
| description | The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus
Clonostachys rogersoniana
strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate
Prorocentrum micans
at 30 µM, but had no effect on other microalgae and bacteria even at 100 µM. |
| doi_str_mv | 10.1038/ja.2005.17 |
| format | Article |
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Clonostachys rogersoniana
strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate
Prorocentrum micans
at 30 µM, but had no effect on other microalgae and bacteria even at 100 µM.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2005.17</identifier><identifier>PMID: 15835726</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino acids ; Animals ; Antiprotozoal Agents - isolation & purification ; Antiprotozoal Agents - pharmacology ; Ascomycota - chemistry ; Bacteriology ; Biological Assay ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Dinoflagellida - drug effects ; Life Sciences ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Medicinal Chemistry ; Microbiology ; Organic Chemistry ; Peptides ; Peptides, Cyclic - isolation & purification ; Peptides, Cyclic - pharmacology</subject><ispartof>Journal of antibiotics, 2005-02, Vol.58 (2), p.145-150</ispartof><rights>Japan Antibiotics Research Association 2005</rights><rights>Copyright Nature Publishing Group Feb 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-c86fc537d29ac70fc2f0d8eb121e4e5b5dd3b130ae50fc6c814183a21958e6623</citedby><cites>FETCH-LOGICAL-c445t-c86fc537d29ac70fc2f0d8eb121e4e5b5dd3b130ae50fc6c814183a21958e6623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15835726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adachi, Kyoko</creatorcontrib><creatorcontrib>Kanoh, Kaneo</creatorcontrib><creatorcontrib>Wisespongp, Puntip</creatorcontrib><creatorcontrib>Nishijima, Miyuki</creatorcontrib><creatorcontrib>Shizuri, Yoshikazu</creatorcontrib><title>Clonostachysins A and B, New Anti-dinoflagellate Cyclic Peptides from a Marine-derived Fungus</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus
Clonostachys rogersoniana
strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate
Prorocentrum micans
at 30 µM, but had no effect on other microalgae and bacteria even at 100 µM.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Antiprotozoal Agents - isolation & purification</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Ascomycota - chemistry</subject><subject>Bacteriology</subject><subject>Biological Assay</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Dinoflagellida - drug effects</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mass Spectrometry</subject><subject>Medicinal Chemistry</subject><subject>Microbiology</subject><subject>Organic Chemistry</subject><subject>Peptides</subject><subject>Peptides, Cyclic - isolation & purification</subject><subject>Peptides, Cyclic - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0c1uEzEUBWALgdq0dMMDIEtIXQCT-trjnyzTqAWkAl20SzRy7DvB0cST2jOgvD2OEgkEC1Ze3M_n2jqEvAI2BSbM1dpOOWNyCvoZmYAxUEGtZs_JhDEOlTGcnZKznNeMCS20OSGnII2QmqsJ-bbo-tjnwbrvuxxipnNqo6fX7-kX_EnncQiVD7FvO7vCrrMD0sXOdcHRe9wOwWOmbeo31NLPNoWIlccUfqCnt2NcjfkledHaLuPF8Twnj7c3D4uP1d3XD58W87vK1bUcKmdU66TQns-s06x1vGXe4BI4YI1yKb0XSxDMoixD5QzUYITlMJMGleLinFwecrepfxoxD80mZLd_cMR-zI3SujZa1v-FoBUYxaHAN3_BdT-mWD5RjNGGF7Pf-_agXOpzTtg22xQ2Nu0aYM2-m2Ztm3035VLBr4-R43KD_jc9llHAuwPIZRRXmP7Y-W_cL41Olko</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Adachi, Kyoko</creator><creator>Kanoh, Kaneo</creator><creator>Wisespongp, Puntip</creator><creator>Nishijima, Miyuki</creator><creator>Shizuri, Yoshikazu</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7T7</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Clonostachysins A and B, New Anti-dinoflagellate Cyclic Peptides from a Marine-derived Fungus</title><author>Adachi, Kyoko ; Kanoh, Kaneo ; Wisespongp, Puntip ; Nishijima, Miyuki ; Shizuri, Yoshikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-c86fc537d29ac70fc2f0d8eb121e4e5b5dd3b130ae50fc6c814183a21958e6623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>Antiprotozoal Agents - isolation & purification</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Ascomycota - chemistry</topic><topic>Bacteriology</topic><topic>Biological Assay</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Dinoflagellida - drug effects</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mass Spectrometry</topic><topic>Medicinal Chemistry</topic><topic>Microbiology</topic><topic>Organic Chemistry</topic><topic>Peptides</topic><topic>Peptides, Cyclic - isolation & purification</topic><topic>Peptides, Cyclic - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adachi, Kyoko</creatorcontrib><creatorcontrib>Kanoh, Kaneo</creatorcontrib><creatorcontrib>Wisespongp, Puntip</creatorcontrib><creatorcontrib>Nishijima, Miyuki</creatorcontrib><creatorcontrib>Shizuri, Yoshikazu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adachi, Kyoko</au><au>Kanoh, Kaneo</au><au>Wisespongp, Puntip</au><au>Nishijima, Miyuki</au><au>Shizuri, Yoshikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clonostachysins A and B, New Anti-dinoflagellate Cyclic Peptides from a Marine-derived Fungus</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>58</volume><issue>2</issue><spage>145</spage><epage>150</epage><pages>145-150</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus
Clonostachys rogersoniana
strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate
Prorocentrum micans
at 30 µM, but had no effect on other microalgae and bacteria even at 100 µM.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15835726</pmid><doi>10.1038/ja.2005.17</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of antibiotics, 2005-02, Vol.58 (2), p.145-150 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino acids Animals Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Ascomycota - chemistry Bacteriology Biological Assay Biomedical and Life Sciences Bioorganic Chemistry Dinoflagellida - drug effects Life Sciences Magnetic Resonance Spectroscopy Mass Spectrometry Medicinal Chemistry Microbiology Organic Chemistry Peptides Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology |
| title | Clonostachysins A and B, New Anti-dinoflagellate Cyclic Peptides from a Marine-derived Fungus |
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