Heparanase Expression at the Invasion Front of Human Head and Neck Cancers and Correlation with Poor Prognosis

Purpose: Head and neck squamous cell carcinomas (HNSCC) are characterized by a poor prognosis due to aggressive, recurrent tumor growth. Expression of the extracellular matrix–degrading enzyme heparanase was associated with poorer prognosis in several cancers. We analyzed the presence of heparanase...

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Veröffentlicht in:	Clinical cancer research 2005-04, Vol.11 (8), p.2899-2906
Hauptverfasser:	BECKHOVE, Philipp, HELMKE, Burkhard M, ZIOUTA, Yvonne, BUCUR, Mariana, DÖRNER, Wolfgang, MOGLER, Carolin, DYCKHOFF, Gerhard, HEROLD-MENDE, Christel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Antineoplastic agents Biological and medical sciences Blotting, Western Cell Line, Tumor Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glucuronidase - genetics Glucuronidase - metabolism Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Humans Immunohistochemistry Lymphatic Metastasis Medical sciences Mice Mice, Inbred NOD Mice, SCID Middle Aged Neoplasm Invasiveness Neoplasm Transplantation NOD/Scid mice Pharmacology. Drug treatments primary tumor culture Prognosis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Survival Analysis Transplantation, Heterologous tumor invasion
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