Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infe...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2006-02, Vol.103 (9), p.3286-3291 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Graham, S.P Pelle, R Honda, Y Mwangi, D.M Tonukari, N.J Yamage, M Glew, E.J De Villiers, E.P Shah, T Bishop, R |
| description | East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naive cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites. |
| doi_str_mv | 10.1073/pnas.0511273103 |
| format | Article |
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The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naive cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0511273103</identifier><identifier>PMID: 16492763</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animals ; Antigens ; Antigens, Protozoan - immunology ; Biological Sciences ; Cattle ; CD8-positive T-lymphocytes ; Cell Line ; cell-mediated immunity ; clones ; Complementary DNA ; cytotoxic T-lymphocytes ; immune response ; Infections ; molecular sequence data ; nucleotide sequences ; Parasites ; Protozoan Vaccines - immunology ; Schizonts ; T lymphocytes ; T-Lymphocytes, Cytotoxic - immunology ; Theileria parva ; Theileria parva - immunology ; Theileriasis - immunology ; Theileriasis - parasitology ; Theileriasis - pathology ; Transponders ; Ungulates ; Vaccination ; vaccine development ; vaccines</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2006-02, Vol.103 (9), p.3286-3291</ispartof><rights>Copyright 2006 National Academy of Sciences of the United States of America</rights><rights>2006 by The National Academy of Sciences of the USA 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-2f46680cfc067a78539d9f0381cdbd3d6237f727b32240cc3a3e6139012428123</citedby><cites>FETCH-LOGICAL-c482t-2f46680cfc067a78539d9f0381cdbd3d6237f727b32240cc3a3e6139012428123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/103/9.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30048575$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30048575$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16492763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graham, S.P</creatorcontrib><creatorcontrib>Pelle, R</creatorcontrib><creatorcontrib>Honda, Y</creatorcontrib><creatorcontrib>Mwangi, D.M</creatorcontrib><creatorcontrib>Tonukari, N.J</creatorcontrib><creatorcontrib>Yamage, M</creatorcontrib><creatorcontrib>Glew, E.J</creatorcontrib><creatorcontrib>De Villiers, E.P</creatorcontrib><creatorcontrib>Shah, T</creatorcontrib><creatorcontrib>Bishop, R</creatorcontrib><title>Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naive cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites.</description><subject>Animals</subject><subject>Antigens</subject><subject>Antigens, Protozoan - immunology</subject><subject>Biological Sciences</subject><subject>Cattle</subject><subject>CD8-positive T-lymphocytes</subject><subject>Cell Line</subject><subject>cell-mediated immunity</subject><subject>clones</subject><subject>Complementary DNA</subject><subject>cytotoxic T-lymphocytes</subject><subject>immune response</subject><subject>Infections</subject><subject>molecular sequence data</subject><subject>nucleotide sequences</subject><subject>Parasites</subject><subject>Protozoan Vaccines - immunology</subject><subject>Schizonts</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Theileria parva</subject><subject>Theileria parva - immunology</subject><subject>Theileriasis - immunology</subject><subject>Theileriasis - parasitology</subject><subject>Theileriasis - pathology</subject><subject>Transponders</subject><subject>Ungulates</subject><subject>Vaccination</subject><subject>vaccine development</subject><subject>vaccines</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2L1DAYh4Mo7rh69qT2pKfuvvlokl4WZPELFjw4ezWkaTqTpW1qkg47_vWmzLCzguApkN_zPrwvP4ReY7jAIOjlNOp4ARXGRFAM9AlaYahxyVkNT9EKgIhSMsLO0IsY7wCgriQ8R2c4A0RwukI_11vrehucLiYddrowemxdq5MtdtoYN9pCj8lt7BiLYI3fjO63bYtmX7hhmHPa-N0CmX3yyd87U6yLfj9MW59_bHyJnnW6j_bV8T1Ht58_ra-_ljffv3y7_nhTGiZJKknHOJdgOgNcaCErWrd1B1Ri0zYtbTmhohNENJQQBsZQTS3HtAZMGJGY0HN0dfBOczPY1tgxBd2rKbhBh73y2qm_k9Ft1cbvFGZZQxbB-6Mg-F-zjUkNLhrb93q0fo6KC8Ek8P-DWICsZcUyeHkATfAxBts9bINBLeWppTx1Ki9PvH18xIk_tpWBD0dgmTzpqKoVJZKrbu77ZO_TI9W_yQy8OQB3MfnwQFAAJitR5fzdIe-0V3oTXFS3PwhgCnl1jCtK_wAB0cFb</recordid><startdate>20060228</startdate><enddate>20060228</enddate><creator>Graham, S.P</creator><creator>Pelle, R</creator><creator>Honda, Y</creator><creator>Mwangi, D.M</creator><creator>Tonukari, N.J</creator><creator>Yamage, M</creator><creator>Glew, E.J</creator><creator>De Villiers, E.P</creator><creator>Shah, T</creator><creator>Bishop, R</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060228</creationdate><title>Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes</title><author>Graham, S.P ; Pelle, R ; Honda, Y ; Mwangi, D.M ; Tonukari, N.J ; Yamage, M ; Glew, E.J ; De Villiers, E.P ; Shah, T ; Bishop, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-2f46680cfc067a78539d9f0381cdbd3d6237f727b32240cc3a3e6139012428123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Antigens, Protozoan - immunology</topic><topic>Biological Sciences</topic><topic>Cattle</topic><topic>CD8-positive T-lymphocytes</topic><topic>Cell Line</topic><topic>cell-mediated immunity</topic><topic>clones</topic><topic>Complementary DNA</topic><topic>cytotoxic T-lymphocytes</topic><topic>immune response</topic><topic>Infections</topic><topic>molecular sequence data</topic><topic>nucleotide sequences</topic><topic>Parasites</topic><topic>Protozoan Vaccines - immunology</topic><topic>Schizonts</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Theileria parva</topic><topic>Theileria parva - immunology</topic><topic>Theileriasis - immunology</topic><topic>Theileriasis - parasitology</topic><topic>Theileriasis - pathology</topic><topic>Transponders</topic><topic>Ungulates</topic><topic>Vaccination</topic><topic>vaccine development</topic><topic>vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graham, S.P</creatorcontrib><creatorcontrib>Pelle, R</creatorcontrib><creatorcontrib>Honda, Y</creatorcontrib><creatorcontrib>Mwangi, D.M</creatorcontrib><creatorcontrib>Tonukari, N.J</creatorcontrib><creatorcontrib>Yamage, M</creatorcontrib><creatorcontrib>Glew, E.J</creatorcontrib><creatorcontrib>De Villiers, E.P</creatorcontrib><creatorcontrib>Shah, T</creatorcontrib><creatorcontrib>Bishop, R</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graham, S.P</au><au>Pelle, R</au><au>Honda, Y</au><au>Mwangi, D.M</au><au>Tonukari, N.J</au><au>Yamage, M</au><au>Glew, E.J</au><au>De Villiers, E.P</au><au>Shah, T</au><au>Bishop, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2006-02-28</date><risdate>2006</risdate><volume>103</volume><issue>9</issue><spage>3286</spage><epage>3291</epage><pages>3286-3291</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naive cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. 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| subjects | Animals Antigens Antigens, Protozoan - immunology Biological Sciences Cattle CD8-positive T-lymphocytes Cell Line cell-mediated immunity clones Complementary DNA cytotoxic T-lymphocytes immune response Infections molecular sequence data nucleotide sequences Parasites Protozoan Vaccines - immunology Schizonts T lymphocytes T-Lymphocytes, Cytotoxic - immunology Theileria parva Theileria parva - immunology Theileriasis - immunology Theileriasis - parasitology Theileriasis - pathology Transponders Ungulates Vaccination vaccine development vaccines |
| title | Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes |
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