Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents

Analysis of gene expression of cancer cell lines exposed to erlotinib, a small molecule inhibitor of the epidermal growth factor receptor (EGFR), showed a marked increase in EGFR mRNA in resistant cell lines but not in susceptible ones. Because cetuximab induces EGFR down-regulation, we explored the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-04, Vol.65 (8), p.3003-3010
Hauptverfasser:	JIMENO, Antonio, RUBIO-VIQUEIRA, Belen, AMADOR, Maria L, OPPENHEIMER, Darin, BOURAOUD, Nadia, KULESZA, Peter, SEBASTIANI, Valeria, MAITRA, Anirban, HIDALGO, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Biliary Tract Neoplasms - drug therapy Biliary Tract Neoplasms - enzymology Biliary Tract Neoplasms - genetics Biological and medical sciences Cell Line, Tumor Cetuximab Cholangiocarcinoma - drug therapy Cholangiocarcinoma - enzymology Cholangiocarcinoma - genetics Erlotinib Hydrochloride Female Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects Gene Silencing Humans Immunohistochemistry Medical sciences Mice Mice, Nude Pharmacology. Drug treatments Protein Kinase Inhibitors - pharmacology Quinazolines - administration & dosage Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - biosynthesis Receptor, Epidermal Growth Factor - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - genetics Transfection
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