Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of Mammalian Endoplasmic Reticulum P450 Proteins

Mammalian hepatic cytochromes P450 (P450s) are endoplasmic reticulum (ER)-anchored hemoproteins with highly variable half-lives. CYP3A4, the dominant human liver drug-metabolizing enzyme, and its rat liver orthologs undergo ubiquitin (Ub)-dependent 26S proteasomal degradation after suicide inactivat...

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Veröffentlicht in:	Molecular pharmacology 2005-05, Vol.67 (5), p.1460-1469
Hauptverfasser:	Liao, Mingxiang, Zgoda, Victor G., Murray, Bernard P., Correia, Maria Almira
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cytochrome P-450 CYP2B1 - chemistry Cytochrome P-450 CYP2B1 - genetics Cytochrome P-450 CYP2B1 - metabolism Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Endoplasmic Reticulum - enzymology Endoplasmic Reticulum - genetics Genotype Liver - enzymology Molecular Sequence Data Protein Structure, Secondary - genetics Rats Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Vacuoles - enzymology Vacuoles - genetics
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