Auxin receptors: a new role for F-box proteins
The plant hormone auxin regulates transcription by promoting the degradation of a family of transcriptional repressors called Aux/IAA proteins. Genetic and biochemical studies have shown that this degradation is dependent on a ubiquitin protein ligase called SCF TIR1. In the presence of auxin, the F...
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| Veröffentlicht in: | Current opinion in cell biology 2006-04, Vol.18 (2), p.152-156 |
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| creator | Parry, Geraint Estelle, Mark |
| description | The plant hormone auxin regulates transcription by promoting the degradation of a family of transcriptional repressors called Aux/IAA proteins. Genetic and biochemical studies have shown that this degradation is dependent on a ubiquitin protein ligase called SCF
TIR1. In the presence of auxin, the F-box protein TIR1 binds to the Aux/IAA proteins, resulting in their ubiquitination and degradation. Recent attention has focused on the nature of the auxin receptor and upstream signaling events involved in this process. Now, two recent papers demonstrate that auxin binds directly to TIR1 and promotes the interaction with the Aux/IAA proteins. Furthermore, TIR1 functions together with at least three other related F-box protein/receptors to mediate the auxin response throughout plant growth and development. |
| doi_str_mv | 10.1016/j.ceb.2006.02.001 |
| format | Article |
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TIR1. In the presence of auxin, the F-box protein TIR1 binds to the Aux/IAA proteins, resulting in their ubiquitination and degradation. Recent attention has focused on the nature of the auxin receptor and upstream signaling events involved in this process. Now, two recent papers demonstrate that auxin binds directly to TIR1 and promotes the interaction with the Aux/IAA proteins. Furthermore, TIR1 functions together with at least three other related F-box protein/receptors to mediate the auxin response throughout plant growth and development.</description><identifier>ISSN: 0955-0674</identifier><identifier>EISSN: 1879-0410</identifier><identifier>DOI: 10.1016/j.ceb.2006.02.001</identifier><identifier>PMID: 16488128</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Arabidopsis Proteins - metabolism ; Arabidopsis Proteins - physiology ; F-Box Proteins - metabolism ; F-Box Proteins - physiology ; Indoleacetic Acids - metabolism ; Plant Proteins - metabolism ; Plant Proteins - physiology ; Receptors, Cell Surface - metabolism ; Receptors, Cell Surface - physiology</subject><ispartof>Current opinion in cell biology, 2006-04, Vol.18 (2), p.152-156</ispartof><rights>2006 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-f9c5f29722573e69f89ed9fe458d00c4cdd2d4691c8a637afcc2e22ead0e33c3</citedby><cites>FETCH-LOGICAL-c448t-f9c5f29722573e69f89ed9fe458d00c4cdd2d4691c8a637afcc2e22ead0e33c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ceb.2006.02.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16488128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parry, Geraint</creatorcontrib><creatorcontrib>Estelle, Mark</creatorcontrib><title>Auxin receptors: a new role for F-box proteins</title><title>Current opinion in cell biology</title><addtitle>Curr Opin Cell Biol</addtitle><description>The plant hormone auxin regulates transcription by promoting the degradation of a family of transcriptional repressors called Aux/IAA proteins. Genetic and biochemical studies have shown that this degradation is dependent on a ubiquitin protein ligase called SCF
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| subjects | Arabidopsis Proteins - metabolism Arabidopsis Proteins - physiology F-Box Proteins - metabolism F-Box Proteins - physiology Indoleacetic Acids - metabolism Plant Proteins - metabolism Plant Proteins - physiology Receptors, Cell Surface - metabolism Receptors, Cell Surface - physiology |
| title | Auxin receptors: a new role for F-box proteins |
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