Single chain antibody fragments for the selective targeting of antigens to dendritic cells

In order to target antigens (Ags) selectively to dendritic cells (DC), we derived single chain antibody fragments (scFvs) from NLDC-145 and N418, two monoclonal antibodies binding the mouse dendritic cell-restricted surface molecules DEC-205 and CD11c. Recombinant hexahistidine-tagged forms of the s...

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Veröffentlicht in:	Molecular immunology 2005-05, Vol.42 (8), p.979-985
Hauptverfasser:	Demangel, Caroline, Zhou, Jie, Choo, Andre B.H., Shoebridge, Grant, Halliday, Gary M., Britton, Warwick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - immunology Baculovirus CD11c CD11c Antigen - immunology DEC-205 Dendritic cell Dendritic Cells - immunology Immunoglobulin Fragments - immunology Langerhans Cells - immunology Lectins, C-Type - immunology Mice Minor Histocompatibility Antigens Receptors, Cell Surface - immunology Single-chain antibody Vaccine
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