Treating renal cell cancer in the elderly
OBJECTIVE To determine whether age and comorbidity are predictors of peri‐operative complications and/or mortality in surgery for renal cell cancer in a retrospective study of patients aged >75 years. PATIENTS AND METHODS Between 1993 and 2003, 1023 radical nephrectomies or nephron‐sparing surger...
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| Veröffentlicht in: | BJU international 2006-04, Vol.97 (4), p.703-705 |
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| creator | BERDJIS, NAVID HAKENBERG, OLIVER W. NOVOTNY, VLADIMIR FROEHNER, MICHAEL WIRTH, MANFRED P. |
| description | OBJECTIVE
To determine whether age and comorbidity are predictors of peri‐operative complications and/or mortality in surgery for renal cell cancer in a retrospective study of patients aged >75 years.
PATIENTS AND METHODS
Between 1993 and 2003, 1023 radical nephrectomies or nephron‐sparing surgery for renal cell cancer were performed in 115 consecutive patients aged ≥ 75 years and in 908 consecutive patients aged |
| doi_str_mv | 10.1111/j.1464-410X.2006.06015.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67744731</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67744731</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5135-563e13ff7869d92a7f98621ab412de7e2194be49e6238778ffe126c4ab4b71d13</originalsourceid><addsrcrecordid>eNqNkDtPwzAQgC0EoqXwF1AWkBgSfPErGRig4qlKLK3EZjnJGVKlabFb0f57HFroiofz6fydff4IiYAmENb1NAEuecyBviUppTKhkoJI1gek_3dw-JvTXPbIifdTSkNBimPSAymYVEL1ydXYoVnW7XvksDVNVGITgmlLdFHdRssPjLCp0DWbU3JkTePxbLcPyOThfjx8ikevj8_D21FcCmAiFpIhMGtVJvMqT42yeSZTMAWHtEKFKeS8QJ6jTFmmVGYtQipLHoBCQQVsQC639y7c_HOFfqlnte_GMi3OV15LpThXrAOzLVi6ufcOrV64embcRgPVnSY91Z0B3dnQnSb9o0mvQ-v57o1VMcNq37jzEoCLHWB8aRrrgpHa7zklZMbCDwbkZst91Q1u_j2AvnuZdBn7BqB5gSY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67744731</pqid></control><display><type>article</type><title>Treating renal cell cancer in the elderly</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>BERDJIS, NAVID ; HAKENBERG, OLIVER W. ; NOVOTNY, VLADIMIR ; FROEHNER, MICHAEL ; WIRTH, MANFRED P.</creator><creatorcontrib>BERDJIS, NAVID ; HAKENBERG, OLIVER W. ; NOVOTNY, VLADIMIR ; FROEHNER, MICHAEL ; WIRTH, MANFRED P.</creatorcontrib><description>OBJECTIVE
To determine whether age and comorbidity are predictors of peri‐operative complications and/or mortality in surgery for renal cell cancer in a retrospective study of patients aged >75 years.
PATIENTS AND METHODS
Between 1993 and 2003, 1023 radical nephrectomies or nephron‐sparing surgery for renal cell cancer were performed in 115 consecutive patients aged ≥ 75 years and in 908 consecutive patients aged <75 years. The preoperative American Society of Anesthesiologists (ASA) score was used for risk stratification. Operative mortality and early complications (within 30 days of surgery) were reviewed.
RESULTS
The younger patients had significantly lower ASA scores than the older patients. There were early complications in 31 of the 908 younger patients (3.4%) and in two of the 115 older patients (1.7%). Peri‐operative mortality was higher in the older than in the younger patients (1.7% vs 0.3%; P = 0.29). Overall morbidity and mortality correlated with increasing ASA score but not with age (P < 0.05).
CONCLUSIONS
Despite greater comorbidity in older patients, their morbidity and mortality did not differ significantly from that of younger patients. Advanced age alone should thus not be used as a criterion to deny surgery for renal cell carcinoma. However, older patients should be counselled regarding a tendency for increased comorbidity‐related peri‐operative mortality.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2006.06015.x</identifier><identifier>PMID: 16536757</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; ASA score ; Biological and medical sciences ; Carcinoma, Renal Cell - mortality ; Carcinoma, Renal Cell - surgery ; Comorbidity ; elderly ; Humans ; Kidney Neoplasms - mortality ; Kidney Neoplasms - surgery ; Kidneys ; Medical sciences ; Middle Aged ; Nephrectomy - methods ; Nephrectomy - mortality ; Nephrology. Urinary tract diseases ; renal cell cancer ; Retrospective Studies ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the genital tract and mammary gland ; surgical treatment ; Treatment Outcome ; Tumors of the urinary system</subject><ispartof>BJU international, 2006-04, Vol.97 (4), p.703-705</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5135-563e13ff7869d92a7f98621ab412de7e2194be49e6238778ffe126c4ab4b71d13</citedby><cites>FETCH-LOGICAL-c5135-563e13ff7869d92a7f98621ab412de7e2194be49e6238778ffe126c4ab4b71d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2006.06015.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2006.06015.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17568362$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16536757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERDJIS, NAVID</creatorcontrib><creatorcontrib>HAKENBERG, OLIVER W.</creatorcontrib><creatorcontrib>NOVOTNY, VLADIMIR</creatorcontrib><creatorcontrib>FROEHNER, MICHAEL</creatorcontrib><creatorcontrib>WIRTH, MANFRED P.</creatorcontrib><title>Treating renal cell cancer in the elderly</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>OBJECTIVE
To determine whether age and comorbidity are predictors of peri‐operative complications and/or mortality in surgery for renal cell cancer in a retrospective study of patients aged >75 years.
PATIENTS AND METHODS
Between 1993 and 2003, 1023 radical nephrectomies or nephron‐sparing surgery for renal cell cancer were performed in 115 consecutive patients aged ≥ 75 years and in 908 consecutive patients aged <75 years. The preoperative American Society of Anesthesiologists (ASA) score was used for risk stratification. Operative mortality and early complications (within 30 days of surgery) were reviewed.
RESULTS
The younger patients had significantly lower ASA scores than the older patients. There were early complications in 31 of the 908 younger patients (3.4%) and in two of the 115 older patients (1.7%). Peri‐operative mortality was higher in the older than in the younger patients (1.7% vs 0.3%; P = 0.29). Overall morbidity and mortality correlated with increasing ASA score but not with age (P < 0.05).
CONCLUSIONS
Despite greater comorbidity in older patients, their morbidity and mortality did not differ significantly from that of younger patients. Advanced age alone should thus not be used as a criterion to deny surgery for renal cell carcinoma. However, older patients should be counselled regarding a tendency for increased comorbidity‐related peri‐operative mortality.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>ASA score</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Renal Cell - mortality</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Comorbidity</subject><subject>elderly</subject><subject>Humans</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - surgery</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrectomy - methods</subject><subject>Nephrectomy - mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>renal cell cancer</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the genital tract and mammary gland</subject><subject>surgical treatment</subject><subject>Treatment Outcome</subject><subject>Tumors of the urinary system</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkDtPwzAQgC0EoqXwF1AWkBgSfPErGRig4qlKLK3EZjnJGVKlabFb0f57HFroiofz6fydff4IiYAmENb1NAEuecyBviUppTKhkoJI1gek_3dw-JvTXPbIifdTSkNBimPSAymYVEL1ydXYoVnW7XvksDVNVGITgmlLdFHdRssPjLCp0DWbU3JkTePxbLcPyOThfjx8ikevj8_D21FcCmAiFpIhMGtVJvMqT42yeSZTMAWHtEKFKeS8QJ6jTFmmVGYtQipLHoBCQQVsQC639y7c_HOFfqlnte_GMi3OV15LpThXrAOzLVi6ufcOrV64embcRgPVnSY91Z0B3dnQnSb9o0mvQ-v57o1VMcNq37jzEoCLHWB8aRrrgpHa7zklZMbCDwbkZst91Q1u_j2AvnuZdBn7BqB5gSY</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>BERDJIS, NAVID</creator><creator>HAKENBERG, OLIVER W.</creator><creator>NOVOTNY, VLADIMIR</creator><creator>FROEHNER, MICHAEL</creator><creator>WIRTH, MANFRED P.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Treating renal cell cancer in the elderly</title><author>BERDJIS, NAVID ; HAKENBERG, OLIVER W. ; NOVOTNY, VLADIMIR ; FROEHNER, MICHAEL ; WIRTH, MANFRED P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5135-563e13ff7869d92a7f98621ab412de7e2194be49e6238778ffe126c4ab4b71d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>ASA score</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Renal Cell - mortality</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Comorbidity</topic><topic>elderly</topic><topic>Humans</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - surgery</topic><topic>Kidneys</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrectomy - methods</topic><topic>Nephrectomy - mortality</topic><topic>Nephrology. Urinary tract diseases</topic><topic>renal cell cancer</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the genital tract and mammary gland</topic><topic>surgical treatment</topic><topic>Treatment Outcome</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERDJIS, NAVID</creatorcontrib><creatorcontrib>HAKENBERG, OLIVER W.</creatorcontrib><creatorcontrib>NOVOTNY, VLADIMIR</creatorcontrib><creatorcontrib>FROEHNER, MICHAEL</creatorcontrib><creatorcontrib>WIRTH, MANFRED P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERDJIS, NAVID</au><au>HAKENBERG, OLIVER W.</au><au>NOVOTNY, VLADIMIR</au><au>FROEHNER, MICHAEL</au><au>WIRTH, MANFRED P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treating renal cell cancer in the elderly</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2006-04</date><risdate>2006</risdate><volume>97</volume><issue>4</issue><spage>703</spage><epage>705</epage><pages>703-705</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><abstract>OBJECTIVE
To determine whether age and comorbidity are predictors of peri‐operative complications and/or mortality in surgery for renal cell cancer in a retrospective study of patients aged >75 years.
PATIENTS AND METHODS
Between 1993 and 2003, 1023 radical nephrectomies or nephron‐sparing surgery for renal cell cancer were performed in 115 consecutive patients aged ≥ 75 years and in 908 consecutive patients aged <75 years. The preoperative American Society of Anesthesiologists (ASA) score was used for risk stratification. Operative mortality and early complications (within 30 days of surgery) were reviewed.
RESULTS
The younger patients had significantly lower ASA scores than the older patients. There were early complications in 31 of the 908 younger patients (3.4%) and in two of the 115 older patients (1.7%). Peri‐operative mortality was higher in the older than in the younger patients (1.7% vs 0.3%; P = 0.29). Overall morbidity and mortality correlated with increasing ASA score but not with age (P < 0.05).
CONCLUSIONS
Despite greater comorbidity in older patients, their morbidity and mortality did not differ significantly from that of younger patients. Advanced age alone should thus not be used as a criterion to deny surgery for renal cell carcinoma. However, older patients should be counselled regarding a tendency for increased comorbidity‐related peri‐operative mortality.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16536757</pmid><doi>10.1111/j.1464-410X.2006.06015.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over ASA score Biological and medical sciences Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - surgery Comorbidity elderly Humans Kidney Neoplasms - mortality Kidney Neoplasms - surgery Kidneys Medical sciences Middle Aged Nephrectomy - methods Nephrectomy - mortality Nephrology. Urinary tract diseases renal cell cancer Retrospective Studies Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland surgical treatment Treatment Outcome Tumors of the urinary system |
| title | Treating renal cell cancer in the elderly |
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