Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B 2) in aqueous solution
The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B 2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously. A model for analysis of ternary systems, which takes into account all poss...
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| Veröffentlicht in: | European journal of pharmaceutical sciences 2006-05, Vol.28 (1), p.59-66 |
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| creator | Evstigneev, M.P. Evstigneev, V.P. Santiago, A.A. Hernandez Davies, D.B. |
| description | The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B
2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously. A model for analysis of ternary systems, which takes into account all possible complexes between the molecules, has been developed and tested with experimental NMR data on the three-component mixture FMN–CAF–NMD. The results indicate that special attention should be given to the concentration of a hydrotropic agent used to enhance the solubility of a particular drug. A decrease in the efficacy of solubility of the vitamin on addition of large amounts of hydrotropic agent is expected in the two-component systems due to the increased proportion of self-association of the hydrotrope. It is found that a mixture of two hydrotropic agents leads to an increase in the solubility of the vitamin in three-component compared to the two-component system. Rather than using just one hydrotropic agent, it is proposed that a strategy for optimising the solubility of aromatic drugs is to use a mixture of hydrotropic agents. |
| doi_str_mv | 10.1016/j.ejps.2005.12.010 |
| format | Article |
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2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously. A model for analysis of ternary systems, which takes into account all possible complexes between the molecules, has been developed and tested with experimental NMR data on the three-component mixture FMN–CAF–NMD. The results indicate that special attention should be given to the concentration of a hydrotropic agent used to enhance the solubility of a particular drug. A decrease in the efficacy of solubility of the vitamin on addition of large amounts of hydrotropic agent is expected in the two-component systems due to the increased proportion of self-association of the hydrotrope. It is found that a mixture of two hydrotropic agents leads to an increase in the solubility of the vitamin in three-component compared to the two-component system. Rather than using just one hydrotropic agent, it is proposed that a strategy for optimising the solubility of aromatic drugs is to use a mixture of hydrotropic agents.</description><identifier>ISSN: 0928-0987</identifier><identifier>EISSN: 1879-0720</identifier><identifier>DOI: 10.1016/j.ejps.2005.12.010</identifier><identifier>PMID: 16483751</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Algorithms ; Biological and medical sciences ; Caffeine ; Caffeine - chemistry ; Chemistry, Pharmaceutical ; Drug Combinations ; General pharmacology ; Hetero-association ; Medical sciences ; Models, Molecular ; Niacinamide - chemistry ; Nicotinamide ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Riboflavin - chemistry ; Solubility ; Solutions ; Vitamin B 2 ; Vitamins - chemistry ; Water</subject><ispartof>European journal of pharmaceutical sciences, 2006-05, Vol.28 (1), p.59-66</ispartof><rights>2006 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-5f61419f85073a45d5717f4843226f1799ed87cdb38f81b95192ef91f8be8e583</citedby><cites>FETCH-LOGICAL-c494t-5f61419f85073a45d5717f4843226f1799ed87cdb38f81b95192ef91f8be8e583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejps.2005.12.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17652540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16483751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evstigneev, M.P.</creatorcontrib><creatorcontrib>Evstigneev, V.P.</creatorcontrib><creatorcontrib>Santiago, A.A. Hernandez</creatorcontrib><creatorcontrib>Davies, D.B.</creatorcontrib><title>Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B 2) in aqueous solution</title><title>European journal of pharmaceutical sciences</title><addtitle>Eur J Pharm Sci</addtitle><description>The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B
2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously. A model for analysis of ternary systems, which takes into account all possible complexes between the molecules, has been developed and tested with experimental NMR data on the three-component mixture FMN–CAF–NMD. The results indicate that special attention should be given to the concentration of a hydrotropic agent used to enhance the solubility of a particular drug. A decrease in the efficacy of solubility of the vitamin on addition of large amounts of hydrotropic agent is expected in the two-component systems due to the increased proportion of self-association of the hydrotrope. It is found that a mixture of two hydrotropic agents leads to an increase in the solubility of the vitamin in three-component compared to the two-component system. Rather than using just one hydrotropic agent, it is proposed that a strategy for optimising the solubility of aromatic drugs is to use a mixture of hydrotropic agents.</description><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Caffeine</subject><subject>Caffeine - chemistry</subject><subject>Chemistry, Pharmaceutical</subject><subject>Drug Combinations</subject><subject>General pharmacology</subject><subject>Hetero-association</subject><subject>Medical sciences</subject><subject>Models, Molecular</subject><subject>Niacinamide - chemistry</subject><subject>Nicotinamide</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Riboflavin - chemistry</subject><subject>Solubility</subject><subject>Solutions</subject><subject>Vitamin B 2</subject><subject>Vitamins - chemistry</subject><subject>Water</subject><issn>0928-0987</issn><issn>1879-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFuFSEUhomxsdfqC7gwbDS6mBEYGCDpRpuqTZp0o2vCMAflZoa5AtPYty_jvUl3roBzvnPy5wOhN5S0lND-076F_SG3jBDRUtYSSp6hHVVSN0Qy8hztiGaqIVrJc_Qy5z0hpFeSvEDntOeqk4Lu0K9r78EVvHhs8Rz-ljXB9nC21kMEbOOIY3BLCdHOYazNiMtvwHmZ1iFMoTxs-H0otRvxhy-YfcT1Yv-ssKz5H1bCEl-hM2-nDK9P5wX6-fX6x9X35vbu283V59vGcc1LI3xPOdVeCSI7y8UoJJWeK94x1nsqtYZRSTcOnfKKDlpQzcBr6tUACoTqLtD7495DWmqEXMwcsoNpsnHLY3opOe-lqCA7gi4tOSfw5pDCbNODocRses3ebHrNptdQZqreOvT2tH0dZhifRk4-K_DuBNjs7OSTjS7kJ072ggm-Lbo8clBd3AdIJrsA0cEYUv0OMy7hfzkeAU2Gl7M</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Evstigneev, M.P.</creator><creator>Evstigneev, V.P.</creator><creator>Santiago, A.A. Hernandez</creator><creator>Davies, D.B.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B 2) in aqueous solution</title><author>Evstigneev, M.P. ; Evstigneev, V.P. ; Santiago, A.A. Hernandez ; Davies, D.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-5f61419f85073a45d5717f4843226f1799ed87cdb38f81b95192ef91f8be8e583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Caffeine</topic><topic>Caffeine - chemistry</topic><topic>Chemistry, Pharmaceutical</topic><topic>Drug Combinations</topic><topic>General pharmacology</topic><topic>Hetero-association</topic><topic>Medical sciences</topic><topic>Models, Molecular</topic><topic>Niacinamide - chemistry</topic><topic>Nicotinamide</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Riboflavin - chemistry</topic><topic>Solubility</topic><topic>Solutions</topic><topic>Vitamin B 2</topic><topic>Vitamins - chemistry</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evstigneev, M.P.</creatorcontrib><creatorcontrib>Evstigneev, V.P.</creatorcontrib><creatorcontrib>Santiago, A.A. Hernandez</creatorcontrib><creatorcontrib>Davies, D.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evstigneev, M.P.</au><au>Evstigneev, V.P.</au><au>Santiago, A.A. 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2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously. A model for analysis of ternary systems, which takes into account all possible complexes between the molecules, has been developed and tested with experimental NMR data on the three-component mixture FMN–CAF–NMD. The results indicate that special attention should be given to the concentration of a hydrotropic agent used to enhance the solubility of a particular drug. A decrease in the efficacy of solubility of the vitamin on addition of large amounts of hydrotropic agent is expected in the two-component systems due to the increased proportion of self-association of the hydrotrope. It is found that a mixture of two hydrotropic agents leads to an increase in the solubility of the vitamin in three-component compared to the two-component system. Rather than using just one hydrotropic agent, it is proposed that a strategy for optimising the solubility of aromatic drugs is to use a mixture of hydrotropic agents.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>16483751</pmid><doi>10.1016/j.ejps.2005.12.010</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Algorithms Biological and medical sciences Caffeine Caffeine - chemistry Chemistry, Pharmaceutical Drug Combinations General pharmacology Hetero-association Medical sciences Models, Molecular Niacinamide - chemistry Nicotinamide Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Riboflavin - chemistry Solubility Solutions Vitamin B 2 Vitamins - chemistry Water |
| title | Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B 2) in aqueous solution |
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