Radiolanthanide-Labeled Monoclonal Antibody CC49 for Radioimmunotherapy of Cancer: Biological Comparison of DOTA Conjugates and 149Pm, 166Ho, and 177Lu

The radiolanthanides 149Pm, 166Ho, and 177Lu have decay characteristics suitable for radioimmunotherapy (RIT) of cancer. N-Hydroxysulfosuccinimidyl DOTA (DOTA-OSSu) and methoxy-DOTA (MeO-DOTA) were conjugated to the anti-TAG-72 monoclonal antibody CC49 for radiolabeling with 149Pm, 166Ho, and 177Lu....

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Veröffentlicht in:	Bioconjugate chemistry 2006-03, Vol.17 (2), p.485-492
Hauptverfasser:	Mohsin, Huma, Jia, Fang, Sivaguru, Geethapriya, Hudson, Michael J, Shelton, Tiffani D, Hoffman, Timothy J, Cutler, Cathy S, Ketring, Alan R, Athey, Phillip S, Simón, Jaime, Frank, R. Keith, Jurisson, Silvia S, Lewis, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neoplasm - chemistry Antibodies, Neoplasm - metabolism Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Cancer Chelating Agents - chemistry Chelating Agents - metabolism Heterocyclic Compounds, 1-Ring - chemistry Heterocyclic Compounds, 1-Ring - metabolism Holmium - chemistry Humans Immunotherapy Kidneys Lanthanoid Series Elements - chemistry Liver Lutetium - chemistry Mice Mice, Nude Molecular Structure Neoplasms - immunology Neoplasms - radiotherapy Promethium - chemistry Radiation therapy Radioisotopes - chemistry Radioisotopes - metabolism Rodents Tissue Distribution
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