Regulation of Vascular Calcification: Roles of Phosphate and Osteopontin
Vascular calcification is prevalent in aging as well as a number of pathological conditions, and it is now recognized as a strong predictor of cardiovascular events in the general population as well as diabetic and end-stage renal disease patients. Vascular calcification is a highly regulated proces...
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| Veröffentlicht in: | Circulation research 2005-04, Vol.96 (7), p.717-722 |
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| container_title | Circulation research |
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| creator | Giachelli, Cecilia M Speer, Mei Y Li, Xianwu Rajachar, Rupak M Yang, Hsueh |
| description | Vascular calcification is prevalent in aging as well as a number of pathological conditions, and it is now recognized as a strong predictor of cardiovascular events in the general population as well as diabetic and end-stage renal disease patients. Vascular calcification is a highly regulated process involving inductive and inhibitory mechanisms. This article focuses on two molecules, phosphate and osteopontin, that have been implicated in the induction or inhibition of vascular calcification, respectively. Elevated phosphate is of interest because hyperphosphatemia is recognized as a major nonconventional risk factor for cardiovascular disease mortality in end-stage renal disease patients. Studies to date suggest that elevated phosphate stimulates smooth muscle cell phenotypic transition and mineralization via the activity of a sodium-dependent phosphate cotransporter. Osteopontin, however, appears to block vascular calcification most likely by preventing calcium phosphate crystal growth and inducing cellular mineral resorption. |
| doi_str_mv | 10.1161/01.RES.0000161997.24797.c0 |
| format | Article |
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Osteopontin, however, appears to block vascular calcification most likely by preventing calcium phosphate crystal growth and inducing cellular mineral resorption.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcinosis - etiology</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Osteopontin</subject><subject>Phosphates - physiology</subject><subject>Sialoglycoproteins - physiology</subject><subject>Transcription Factor Pit-1</subject><subject>Transcription Factors - physiology</subject><subject>Vascular Diseases - etiology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAQgK2Kqmyhf6GKkOgt2xk_4oQbWlGohES1Ba6W49jdFG-82IlQ_z3eh7TH-mBrxt94xh8hFwhzxAq_A86XN7_nkFcOm0bOKZd5N_CBzFBQXnIh8YTMMtCUkjE4JZ9T-ptxzmjziZyiqBnWlM3I3dL-mbwe-zAUwRXPOpkcxmKhveldb3Y3V8UyeJu2wK9VSJuVHm2hh654SKMNmzCM_XBOPjrtk_1yOM_I04-bx8Vdef9w-3NxfV8aDrQqW1c5noeu2s4hYMcFNsg609Yux0Ap6yTjNasltvkTJg8KLOdrMAi6E-yMfNu_u4nhdbJpVOs-Geu9HmyYkqqk5EyI5r8gNpJKtgOv9qCJIaVondrEfq3jP4WgtsIVoMrC1VG42glXBnLx10OXqV3b7lh6MJyBywOQ1Wrvoh5Mn45cJUHUNWaO77m34Ecb04uf3mxUK6v9uNq1ZoC0pAACOAoot6mKvQOQFpcc</recordid><startdate>20050415</startdate><enddate>20050415</enddate><creator>Giachelli, Cecilia M</creator><creator>Speer, Mei Y</creator><creator>Li, Xianwu</creator><creator>Rajachar, Rupak M</creator><creator>Yang, Hsueh</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20050415</creationdate><title>Regulation of Vascular Calcification: Roles of Phosphate and Osteopontin</title><author>Giachelli, Cecilia M ; Speer, Mei Y ; Li, Xianwu ; Rajachar, Rupak M ; Yang, Hsueh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4026-bf6f46196bdf101d451913dcb8ff100223d73483871b571c5830300280c10ad53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcinosis - etiology</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Osteopontin</topic><topic>Phosphates - physiology</topic><topic>Sialoglycoproteins - physiology</topic><topic>Transcription Factor Pit-1</topic><topic>Transcription Factors - physiology</topic><topic>Vascular Diseases - etiology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giachelli, Cecilia M</creatorcontrib><creatorcontrib>Speer, Mei Y</creatorcontrib><creatorcontrib>Li, Xianwu</creatorcontrib><creatorcontrib>Rajachar, Rupak M</creatorcontrib><creatorcontrib>Yang, Hsueh</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giachelli, Cecilia M</au><au>Speer, Mei Y</au><au>Li, Xianwu</au><au>Rajachar, Rupak M</au><au>Yang, Hsueh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of Vascular Calcification: Roles of Phosphate and Osteopontin</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>2005-04-15</date><risdate>2005</risdate><volume>96</volume><issue>7</issue><spage>717</spage><epage>722</epage><pages>717-722</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><coden>CIRUAL</coden><abstract>Vascular calcification is prevalent in aging as well as a number of pathological conditions, and it is now recognized as a strong predictor of cardiovascular events in the general population as well as diabetic and end-stage renal disease patients. 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| fulltext | fulltext |
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| ispartof | Circulation research, 2005-04, Vol.96 (7), p.717-722 |
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| language | eng |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Calcinosis - etiology DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology Humans Muscle, Smooth, Vascular - cytology Osteopontin Phosphates - physiology Sialoglycoproteins - physiology Transcription Factor Pit-1 Transcription Factors - physiology Vascular Diseases - etiology Vertebrates: cardiovascular system |
| title | Regulation of Vascular Calcification: Roles of Phosphate and Osteopontin |
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