The nuclear pore complex : The gateway to successful nonviral gene delivery
One of the limiting steps in the efficiency of nonviral gene delivery is transport of genetic material across the nuclear membrane. Trafficking of nuclear proteins from the cytoplasm into the nucleus occurs via the nuclear pore complex and is mediated by nuclear localization signals and their nuclea...
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| Veröffentlicht in: | Pharmaceutical research 2006-03, Vol.23 (3), p.447-459 |
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| container_title | Pharmaceutical research |
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| creator | VAN DER AA, Marieke A. E. M MASTROBATTISTA, Enrico COSTING, Ronald S HENNINK, Wim E KONING, Gerben A CROMMELIN, Daan J. A |
| description | One of the limiting steps in the efficiency of nonviral gene delivery is transport of genetic material across the nuclear membrane. Trafficking of nuclear proteins from the cytoplasm into the nucleus occurs via the nuclear pore complex and is mediated by nuclear localization signals and their nuclear receptors. Several strategies employing this transport mechanism have been designed and explored to improve nonviral gene delivery. In this article, we review the mechanism of nuclear import through the nuclear pore complex and the strategies used to facilitate nuclear import of exogenous DNA and improve gene expression. |
| doi_str_mv | 10.1007/s11095-005-9445-4 |
| format | Article |
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| subjects | Active Transport, Cell Nucleus Animals Biological and medical sciences Cell division Cell Nucleus - metabolism Cytoplasm DNA - genetics DNA - metabolism Gene expression Gene Transfer Techniques General pharmacology Humans Karyopherins - metabolism Localization Medical sciences Nuclear Localization Signals - metabolism Nuclear Pore - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene glycol Proteins Radiation |
| title | The nuclear pore complex : The gateway to successful nonviral gene delivery |
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