Neurosteroid Analogues. 10. The Effect of Methyl Group Substitution at the C-6 and C-7 Positions on the GABA Modulatory and Anesthetic Actions of (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one

The planar 5α-reduced steroid (3α,5α)-3-hydroxypregnan-20-one and the nonplanar 5β-reduced steroid (3α,5β)-3-hydroxypregnan-20-one act at GABAA receptors to induce general anesthesia. The structural features of the binding sites for these anesthetic steroids on GABAA receptors have not been determin...

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