Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis
No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date. Increasing evidence indicates myocardial dysfunctions in affected fetuses and newborns. We sought to assess t...
Gespeichert in:
| Veröffentlicht in: | Pediatric critical care medicine 2006-03, Vol.7 (2), p.138-142 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 142 |
|---|---|
| container_issue | 2 |
| container_start_page | 138 |
| container_title | Pediatric critical care medicine |
| container_volume | 7 |
| creator | De Felice, Claudio Goldstein, Mitchell R Parrini, Stefano Verrotti, Alberto Criscuolo, Mario Latini, Giuseppe |
| description | No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date. Increasing evidence indicates myocardial dysfunctions in affected fetuses and newborns. We sought to assess the value of nonlinear dynamics from pulse oximetry signals in identifying affected newborns.
Prospective case-control study.
Tertiary level neonatal intensive care unit, Brindisi Hospital.
Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
Four different time series parameters were determined for nonlinear dynamical (NLD) analysis. Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA. Heart rate Lempel-Ziv |
| doi_str_mv | 10.1097/01.PCC.0000201002.50708.62 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67742872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67742872</sourcerecordid><originalsourceid>FETCH-LOGICAL-c317t-67c62f01e49fec8aadd63b72fbad5fab0d2765db93933d6d062ed9a97e7329103</originalsourceid><addsrcrecordid>eNpFkMtOwzAQRb0A0VL4BWSxYJfgR23X7FBUHlIlWMDacmKnNUrsYicq-XvSh9RZzCzm3juaA8A9RjlGUjwinH8WRY7GIgiPLWdIoEXOyQWYYkZkJhhlE3Cd0g9CWPK5uAITPI45YWwKzFLHZoBm8Lp1Faw22q9tgs7Dbd8kC8Ofa20XB5jc2uvmuIm2s7GF3u7KEH2CO9dt4MalLjRhfUgJ0QXdehe861y6AZf16LW3pzkD3y_Lr-ItW328vhfPq6yiWHQZFxUnNcJ2LmtbLbQ2htNSkLrUhtW6RIYIzkwpqaTUcIM4sUZqKaygRGJEZ-DhmLuN4be3qVOtS5VtGu1t6JPiYvx6IcgofDoKqxhSirZW2-haHQeFkdpzVQirkas6c1UHrorvzXenK33ZWnO2nqDSf4UmeP8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67742872</pqid></control><display><type>article</type><title>Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>De Felice, Claudio ; Goldstein, Mitchell R ; Parrini, Stefano ; Verrotti, Alberto ; Criscuolo, Mario ; Latini, Giuseppe</creator><creatorcontrib>De Felice, Claudio ; Goldstein, Mitchell R ; Parrini, Stefano ; Verrotti, Alberto ; Criscuolo, Mario ; Latini, Giuseppe</creatorcontrib><description>No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date. Increasing evidence indicates myocardial dysfunctions in affected fetuses and newborns. We sought to assess the value of nonlinear dynamics from pulse oximetry signals in identifying affected newborns.
Prospective case-control study.
Tertiary level neonatal intensive care unit, Brindisi Hospital.
Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
Four different time series parameters were determined for nonlinear dynamical (NLD) analysis. Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA. Heart rate Lempel-Ziv </=0.218 showed 100% sensitivity (95% confidence interval, 98.8-100) and 100% specificity (95% confidence interval, 98.6-100) in distinguishing cases from controls, with positive and negative predictive values of 100% and 95.7%, respectively.
Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants.</description><identifier>ISSN: 1529-7535</identifier><identifier>DOI: 10.1097/01.PCC.0000201002.50708.62</identifier><identifier>PMID: 16474255</identifier><language>eng</language><publisher>United States</publisher><subject>Case-Control Studies ; Chorioamnionitis - diagnosis ; Chorioamnionitis - pathology ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal ; Male ; Oximetry ; Pregnancy ; Prospective Studies</subject><ispartof>Pediatric critical care medicine, 2006-03, Vol.7 (2), p.138-142</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-67c62f01e49fec8aadd63b72fbad5fab0d2765db93933d6d062ed9a97e7329103</citedby><cites>FETCH-LOGICAL-c317t-67c62f01e49fec8aadd63b72fbad5fab0d2765db93933d6d062ed9a97e7329103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16474255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Felice, Claudio</creatorcontrib><creatorcontrib>Goldstein, Mitchell R</creatorcontrib><creatorcontrib>Parrini, Stefano</creatorcontrib><creatorcontrib>Verrotti, Alberto</creatorcontrib><creatorcontrib>Criscuolo, Mario</creatorcontrib><creatorcontrib>Latini, Giuseppe</creatorcontrib><title>Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis</title><title>Pediatric critical care medicine</title><addtitle>Pediatr Crit Care Med</addtitle><description>No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date. Increasing evidence indicates myocardial dysfunctions in affected fetuses and newborns. We sought to assess the value of nonlinear dynamics from pulse oximetry signals in identifying affected newborns.
Prospective case-control study.
Tertiary level neonatal intensive care unit, Brindisi Hospital.
Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
Four different time series parameters were determined for nonlinear dynamical (NLD) analysis. Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA. Heart rate Lempel-Ziv </=0.218 showed 100% sensitivity (95% confidence interval, 98.8-100) and 100% specificity (95% confidence interval, 98.6-100) in distinguishing cases from controls, with positive and negative predictive values of 100% and 95.7%, respectively.
Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants.</description><subject>Case-Control Studies</subject><subject>Chorioamnionitis - diagnosis</subject><subject>Chorioamnionitis - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Very Low Birth Weight</subject><subject>Intensive Care Units, Neonatal</subject><subject>Male</subject><subject>Oximetry</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><issn>1529-7535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRb0A0VL4BWSxYJfgR23X7FBUHlIlWMDacmKnNUrsYicq-XvSh9RZzCzm3juaA8A9RjlGUjwinH8WRY7GIgiPLWdIoEXOyQWYYkZkJhhlE3Cd0g9CWPK5uAITPI45YWwKzFLHZoBm8Lp1Faw22q9tgs7Dbd8kC8Ofa20XB5jc2uvmuIm2s7GF3u7KEH2CO9dt4MalLjRhfUgJ0QXdehe861y6AZf16LW3pzkD3y_Lr-ItW328vhfPq6yiWHQZFxUnNcJ2LmtbLbQ2htNSkLrUhtW6RIYIzkwpqaTUcIM4sUZqKaygRGJEZ-DhmLuN4be3qVOtS5VtGu1t6JPiYvx6IcgofDoKqxhSirZW2-haHQeFkdpzVQirkas6c1UHrorvzXenK33ZWnO2nqDSf4UmeP8</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>De Felice, Claudio</creator><creator>Goldstein, Mitchell R</creator><creator>Parrini, Stefano</creator><creator>Verrotti, Alberto</creator><creator>Criscuolo, Mario</creator><creator>Latini, Giuseppe</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis</title><author>De Felice, Claudio ; Goldstein, Mitchell R ; Parrini, Stefano ; Verrotti, Alberto ; Criscuolo, Mario ; Latini, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-67c62f01e49fec8aadd63b72fbad5fab0d2765db93933d6d062ed9a97e7329103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Case-Control Studies</topic><topic>Chorioamnionitis - diagnosis</topic><topic>Chorioamnionitis - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Very Low Birth Weight</topic><topic>Intensive Care Units, Neonatal</topic><topic>Male</topic><topic>Oximetry</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Felice, Claudio</creatorcontrib><creatorcontrib>Goldstein, Mitchell R</creatorcontrib><creatorcontrib>Parrini, Stefano</creatorcontrib><creatorcontrib>Verrotti, Alberto</creatorcontrib><creatorcontrib>Criscuolo, Mario</creatorcontrib><creatorcontrib>Latini, Giuseppe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Felice, Claudio</au><au>Goldstein, Mitchell R</au><au>Parrini, Stefano</au><au>Verrotti, Alberto</au><au>Criscuolo, Mario</au><au>Latini, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis</atitle><jtitle>Pediatric critical care medicine</jtitle><addtitle>Pediatr Crit Care Med</addtitle><date>2006-03</date><risdate>2006</risdate><volume>7</volume><issue>2</issue><spage>138</spage><epage>142</epage><pages>138-142</pages><issn>1529-7535</issn><abstract>No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date. Increasing evidence indicates myocardial dysfunctions in affected fetuses and newborns. We sought to assess the value of nonlinear dynamics from pulse oximetry signals in identifying affected newborns.
Prospective case-control study.
Tertiary level neonatal intensive care unit, Brindisi Hospital.
Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
Four different time series parameters were determined for nonlinear dynamical (NLD) analysis. Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA. Heart rate Lempel-Ziv </=0.218 showed 100% sensitivity (95% confidence interval, 98.8-100) and 100% specificity (95% confidence interval, 98.6-100) in distinguishing cases from controls, with positive and negative predictive values of 100% and 95.7%, respectively.
Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants.</abstract><cop>United States</cop><pmid>16474255</pmid><doi>10.1097/01.PCC.0000201002.50708.62</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1529-7535 |
| ispartof | Pediatric critical care medicine, 2006-03, Vol.7 (2), p.138-142 |
| issn | 1529-7535 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67742872 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Case-Control Studies Chorioamnionitis - diagnosis Chorioamnionitis - pathology Female Humans Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Intensive Care Units, Neonatal Male Oximetry Pregnancy Prospective Studies |
| title | Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T17%3A07%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20dynamic%20changes%20in%20pulse%20oximetry%20signals%20in%20preterm%20newborns%20with%20histologic%20chorioamnionitis&rft.jtitle=Pediatric%20critical%20care%20medicine&rft.au=De%20Felice,%20Claudio&rft.date=2006-03&rft.volume=7&rft.issue=2&rft.spage=138&rft.epage=142&rft.pages=138-142&rft.issn=1529-7535&rft_id=info:doi/10.1097/01.PCC.0000201002.50708.62&rft_dat=%3Cproquest_cross%3E67742872%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67742872&rft_id=info:pmid/16474255&rfr_iscdi=true |