Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals

Hepatocellular carcinoma is highly resistant to chemotherapeutic agents, thus the need to discover effective therapeutic molecules to suppress cancer cell growth and to overcome drug resistance is urgent. The Rho GTPase is implicated in cancer and metastasis and is directly activated by the Lymphoid...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2006-04, Vol.290 (4), p.G624-G632
Hauptverfasser:	Sterpetti, Paola, Marucci, Luca, Candelaresi, Cinzia, Toksoz, Deniz, Alpini, Gianfranco, Ugili, Laura, Baroni, Gianluca Svegliati, Macarri, Giampiero, Benedetti, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins Adaptor Proteins, Signal Transducing - metabolism Antineoplastic Agents - administration & dosage Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation Dose-Response Relationship, Drug Doxorubicin - administration & dosage Drug Resistance, Neoplasm Female Gallbladder Neoplasms - drug therapy Gallbladder Neoplasms - metabolism Gallbladder Neoplasms - pathology Humans Liver - drug effects Liver - metabolism Liver - pathology Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Minor Histocompatibility Antigens Proto-Oncogene Proteins - metabolism rho GTP-Binding Proteins - metabolism Signal Transduction - drug effects
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