Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition

Background The role of erbB tyrosine kinases, especially Her‐2, in osteosarcoma has engendered intense debate. Some investigators identified an association between low‐level Her‐2 expression, compared to none, and poor patient outcome. Others questioned the importance of apparent cytoplasmic express...

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Veröffentlicht in:	Pediatric Blood & Cancer 2006-05, Vol.46 (5), p.614-623
Hauptverfasser:	Hughes, Dennis P.M., Thomas, Dafydd G., Giordano, Thomas J., McDonagh, Kevin T., Baker, Laurence H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biological and medical sciences Blotting, Western Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Cell Membrane - metabolism Cell Nucleus - metabolism CI-1033 EGFR Enzyme-Linked Immunosorbent Assay ErbB Flow Cytometry Gene Expression Regulation, Neoplastic General aspects Her-2 Her-4 Humans Immunoenzyme Techniques Medical sciences Morpholines - pharmacology osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism phosphorylation Phosphorylation - drug effects Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - metabolism Receptor, ErbB-4 signaling Tumor Cells, Cultured Tumors tyrosine kinase
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