Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women
OBJECTIVE: Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk fa...
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| Veröffentlicht in: | International Journal of Obesity 2005-05, Vol.29 (5), p.498-501 |
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| container_issue | 5 |
| container_start_page | 498 |
| container_title | International Journal of Obesity |
| container_volume | 29 |
| creator | Laimer, M Kaser, S Kranebitter, M Sandhofer, A Mühlmann, G Schwelberger, H Weiss, H Patsch, J R Ebenbichler, C F |
| description | OBJECTIVE:
Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk factors. Matrix metalloproteinase-9 (MMP-9) has been linked to plaque rupture, and is, thus, a candidate marker of future myocardial events. The aim of this study was to determine the influence of weight loss on MMP-9 plasma concentrations.
METHODS AND RESULTS:
CRP, IL-6 and MMP-9 were analyzed from samples of 45 morbidly obese, middle-aged women before gastric banding and 1 y postsurgical treatment in this prospective study. The body mass index (BMI) of subjects decreased from 42.5±4.9 to 32.3±5.3 kg/m
2
1 y after gastric banding. In parallel, both MMP-9 and CRP were reduced by 23 and 41%, respectively. A positive relationship was found between BMI and MMP-9 (
r
=0.312,
P |
| doi_str_mv | 10.1038/sj.ijo.0802897 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67742263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188448360</galeid><sourcerecordid>A188448360</sourcerecordid><originalsourceid>FETCH-LOGICAL-c500t-e30cbf7f5c9f69c6729c21c279b9f0cbd93524656b3a6a5d06847cc20deef1053</originalsourceid><addsrcrecordid>eNp1kk1v1DAQhiMEokvhyhFZSHDL1nZiOzlWVQtIlbjAOXLs8a5Txy62Q-m_4CfXy0ZagYR8GMnzzNc7U1VvCd4S3HQXadraKWxxh2nXi2fVhrSC16ztxfNqgxssasw4O6tepTRhjBnD9GV1RhjvGG35pvp9bQyojIJB9zH4sHgFGj2A3e0zciElFDzKe0A--BylttkGLx1SMmobfsqkFicjijbdoVnGO4jF5Gh_oRmydC6UrBmslwnqHlmPZqu1g1ruSpk5xNFq94jCCAnQQ5jBv65eGOkSvFntefX95vrb1ef69uunL1eXt7ViGOcaGqxGIwxTveG94oL2ihJFRT_2prh03xwGZHxsJJdMY961QimKNYAhmDXn1cdj3tLgjwVSHmabFDgnPYQlDVyIllLeFPD9P-AUllg0SAMlPRUd6XCBtkdoJx0M1ptQxFLlaZitCh6MLf-XpOvatms4PpX_E7AH6fI-Bbcc5E1_g2tmFcs2IpjhPtqi9ONA8HA4gSFNQzmBYT2BEvBu7XcZZ9AnfN15AT6sQNmedCZKr2w6cVwQylpSuIsjl4rL7yCeBv9P6Sew6cwE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219278180</pqid></control><display><type>article</type><title>Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women</title><source>MEDLINE</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Laimer, M ; Kaser, S ; Kranebitter, M ; Sandhofer, A ; Mühlmann, G ; Schwelberger, H ; Weiss, H ; Patsch, J R ; Ebenbichler, C F</creator><creatorcontrib>Laimer, M ; Kaser, S ; Kranebitter, M ; Sandhofer, A ; Mühlmann, G ; Schwelberger, H ; Weiss, H ; Patsch, J R ; Ebenbichler, C F</creatorcontrib><description>OBJECTIVE:
Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk factors. Matrix metalloproteinase-9 (MMP-9) has been linked to plaque rupture, and is, thus, a candidate marker of future myocardial events. The aim of this study was to determine the influence of weight loss on MMP-9 plasma concentrations.
METHODS AND RESULTS:
CRP, IL-6 and MMP-9 were analyzed from samples of 45 morbidly obese, middle-aged women before gastric banding and 1 y postsurgical treatment in this prospective study. The body mass index (BMI) of subjects decreased from 42.5±4.9 to 32.3±5.3 kg/m
2
1 y after gastric banding. In parallel, both MMP-9 and CRP were reduced by 23 and 41%, respectively. A positive relationship was found between BMI and MMP-9 (
r
=0.312,
P
<0.05), and between CRP and IL-6 (
r
=0.508,
P
<0.05), whereas no correlation was found between CRP and MMP-9.
CONCLUSIONS:
We conclude that weight loss is associated with a pronounced decrease in the nontraditional cardiovascular risk markers MMP-9 and CRP, which could indicate future beneficial effects of weight loss on the cardiovascular risk in weight loosing subjects.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802897</identifier><identifier>PMID: 15685246</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Body mass index ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - physiopathology ; Coronary heart disease ; Cytokines ; Drug dosages ; Epidemiology ; Female ; Gastrointestinal surgery ; Health Promotion and Disease Prevention ; Health risks ; Heart ; Humans ; Inflammation ; Insulin resistance ; Interleukin-6 - blood ; Internal Medicine ; Matrix Metalloproteinase 9 - blood ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic disorders ; Middle age ; Morbidity ; Mortality ; Obesity ; Obesity - blood ; Plasma ; Prospective Studies ; Proteins ; Public Health ; Risk Factors ; Weight control ; Weight Loss - physiology ; Womens health</subject><ispartof>International Journal of Obesity, 2005-05, Vol.29 (5), p.498-501</ispartof><rights>Springer Nature Limited 2005</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-e30cbf7f5c9f69c6729c21c279b9f0cbd93524656b3a6a5d06847cc20deef1053</citedby><cites>FETCH-LOGICAL-c500t-e30cbf7f5c9f69c6729c21c279b9f0cbd93524656b3a6a5d06847cc20deef1053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0802897$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0802897$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16712541$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15685246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laimer, M</creatorcontrib><creatorcontrib>Kaser, S</creatorcontrib><creatorcontrib>Kranebitter, M</creatorcontrib><creatorcontrib>Sandhofer, A</creatorcontrib><creatorcontrib>Mühlmann, G</creatorcontrib><creatorcontrib>Schwelberger, H</creatorcontrib><creatorcontrib>Weiss, H</creatorcontrib><creatorcontrib>Patsch, J R</creatorcontrib><creatorcontrib>Ebenbichler, C F</creatorcontrib><title>Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>OBJECTIVE:
Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk factors. Matrix metalloproteinase-9 (MMP-9) has been linked to plaque rupture, and is, thus, a candidate marker of future myocardial events. The aim of this study was to determine the influence of weight loss on MMP-9 plasma concentrations.
METHODS AND RESULTS:
CRP, IL-6 and MMP-9 were analyzed from samples of 45 morbidly obese, middle-aged women before gastric banding and 1 y postsurgical treatment in this prospective study. The body mass index (BMI) of subjects decreased from 42.5±4.9 to 32.3±5.3 kg/m
2
1 y after gastric banding. In parallel, both MMP-9 and CRP were reduced by 23 and 41%, respectively. A positive relationship was found between BMI and MMP-9 (
r
=0.312,
P
<0.05), and between CRP and IL-6 (
r
=0.508,
P
<0.05), whereas no correlation was found between CRP and MMP-9.
CONCLUSIONS:
We conclude that weight loss is associated with a pronounced decrease in the nontraditional cardiovascular risk markers MMP-9 and CRP, which could indicate future beneficial effects of weight loss on the cardiovascular risk in weight loosing subjects.</description><subject>Adult</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Body mass index</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Coronary heart disease</subject><subject>Cytokines</subject><subject>Drug dosages</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Health Promotion and Disease Prevention</subject><subject>Health risks</subject><subject>Heart</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Interleukin-6 - blood</subject><subject>Internal Medicine</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolic disorders</subject><subject>Middle age</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Public Health</subject><subject>Risk Factors</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><subject>Womens health</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kk1v1DAQhiMEokvhyhFZSHDL1nZiOzlWVQtIlbjAOXLs8a5Txy62Q-m_4CfXy0ZagYR8GMnzzNc7U1VvCd4S3HQXadraKWxxh2nXi2fVhrSC16ztxfNqgxssasw4O6tepTRhjBnD9GV1RhjvGG35pvp9bQyojIJB9zH4sHgFGj2A3e0zciElFDzKe0A--BylttkGLx1SMmobfsqkFicjijbdoVnGO4jF5Gh_oRmydC6UrBmslwnqHlmPZqu1g1ruSpk5xNFq94jCCAnQQ5jBv65eGOkSvFntefX95vrb1ef69uunL1eXt7ViGOcaGqxGIwxTveG94oL2ihJFRT_2prh03xwGZHxsJJdMY961QimKNYAhmDXn1cdj3tLgjwVSHmabFDgnPYQlDVyIllLeFPD9P-AUllg0SAMlPRUd6XCBtkdoJx0M1ptQxFLlaZitCh6MLf-XpOvatms4PpX_E7AH6fI-Bbcc5E1_g2tmFcs2IpjhPtqi9ONA8HA4gSFNQzmBYT2BEvBu7XcZZ9AnfN15AT6sQNmedCZKr2w6cVwQylpSuIsjl4rL7yCeBv9P6Sew6cwE</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Laimer, M</creator><creator>Kaser, S</creator><creator>Kranebitter, M</creator><creator>Sandhofer, A</creator><creator>Mühlmann, G</creator><creator>Schwelberger, H</creator><creator>Weiss, H</creator><creator>Patsch, J R</creator><creator>Ebenbichler, C F</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women</title><author>Laimer, M ; Kaser, S ; Kranebitter, M ; Sandhofer, A ; Mühlmann, G ; Schwelberger, H ; Weiss, H ; Patsch, J R ; Ebenbichler, C F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-e30cbf7f5c9f69c6729c21c279b9f0cbd93524656b3a6a5d06847cc20deef1053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Body mass index</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Coronary heart disease</topic><topic>Cytokines</topic><topic>Drug dosages</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Health Promotion and Disease Prevention</topic><topic>Health risks</topic><topic>Heart</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Interleukin-6 - blood</topic><topic>Internal Medicine</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolic disorders</topic><topic>Middle age</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Public Health</topic><topic>Risk Factors</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laimer, M</creatorcontrib><creatorcontrib>Kaser, S</creatorcontrib><creatorcontrib>Kranebitter, M</creatorcontrib><creatorcontrib>Sandhofer, A</creatorcontrib><creatorcontrib>Mühlmann, G</creatorcontrib><creatorcontrib>Schwelberger, H</creatorcontrib><creatorcontrib>Weiss, H</creatorcontrib><creatorcontrib>Patsch, J R</creatorcontrib><creatorcontrib>Ebenbichler, C F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laimer, M</au><au>Kaser, S</au><au>Kranebitter, M</au><au>Sandhofer, A</au><au>Mühlmann, G</au><au>Schwelberger, H</au><au>Weiss, H</au><au>Patsch, J R</au><au>Ebenbichler, C F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>29</volume><issue>5</issue><spage>498</spage><epage>501</epage><pages>498-501</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE:
Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk factors. Matrix metalloproteinase-9 (MMP-9) has been linked to plaque rupture, and is, thus, a candidate marker of future myocardial events. The aim of this study was to determine the influence of weight loss on MMP-9 plasma concentrations.
METHODS AND RESULTS:
CRP, IL-6 and MMP-9 were analyzed from samples of 45 morbidly obese, middle-aged women before gastric banding and 1 y postsurgical treatment in this prospective study. The body mass index (BMI) of subjects decreased from 42.5±4.9 to 32.3±5.3 kg/m
2
1 y after gastric banding. In parallel, both MMP-9 and CRP were reduced by 23 and 41%, respectively. A positive relationship was found between BMI and MMP-9 (
r
=0.312,
P
<0.05), and between CRP and IL-6 (
r
=0.508,
P
<0.05), whereas no correlation was found between CRP and MMP-9.
CONCLUSIONS:
We conclude that weight loss is associated with a pronounced decrease in the nontraditional cardiovascular risk markers MMP-9 and CRP, which could indicate future beneficial effects of weight loss on the cardiovascular risk in weight loosing subjects.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15685246</pmid><doi>10.1038/sj.ijo.0802897</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International Journal of Obesity, 2005-05, Vol.29 (5), p.498-501 |
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| language | eng |
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| source | MEDLINE; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Adult Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Body mass index C-Reactive Protein - analysis Cardiology. Vascular system Cardiovascular Diseases - blood Cardiovascular Diseases - physiopathology Coronary heart disease Cytokines Drug dosages Epidemiology Female Gastrointestinal surgery Health Promotion and Disease Prevention Health risks Heart Humans Inflammation Insulin resistance Interleukin-6 - blood Internal Medicine Matrix Metalloproteinase 9 - blood Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Middle age Morbidity Mortality Obesity Obesity - blood Plasma Prospective Studies Proteins Public Health Risk Factors Weight control Weight Loss - physiology Womens health |
| title | Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women |
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