Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients
Background. Patients with end-stage renal disease have a high risk of premature death, which is due mainly to cardiovascular (CV) events. Elevated cardiac troponin T (cTnT) is related to increased left ventricular mass index (LVMI) and predicts poor outcome in chronic haemodialysis patients. We inve...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2005-05, Vol.20 (5), p.962-967 |
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| creator | Duman, Dursun Tokay, Sena Toprak, Ahmet Duman, Deniz Oktay, Ahmet Ozener, Ishak Cetin |
| description | Background. Patients with end-stage renal disease have a high risk of premature death, which is due mainly to cardiovascular (CV) events. Elevated cardiac troponin T (cTnT) is related to increased left ventricular mass index (LVMI) and predicts poor outcome in chronic haemodialysis patients. We investigated the prognostic value of cTnT and its relationship with left ventricular mass in continuous ambulatory peritoneal dialysis (CAPD) patients. Methods. Sixty-five CAPD patients (mean age: 56±12 years; 36% males) with no evidence of acute coronary syndrome in 28 days prior to the study were examined prospectively. After 48 months of follow-up, we evaluated total and CV mortality. Results. During follow-up, 23 patients (35%) died (70% CV causes, 22% infection, 4% tumour, 4% unknown). In univariate analysis, concentrations of cTnT ≥0.035 ng/ml, increased LVMI, diabetes, serum albumin and age were all strong predictors of total mortality. In multivariate logistic regression analysis, cTnT ≥0.035 ng/ml and age independently predicted total mortality [odds ratio (OR): 4.31; 95% confidence interval (95% CI): 1.16–16.04; P = 0.008 and OR: 1.08; 95% CI: 1.02–1.15; P = 0.002, respectively]. cTnT level ≥0.035 ng/ml was the only independent predictor of CV mortality in multivariate logistic regression analysis (OR: 8.94; 95% CI: 2.23–35.88; P |
| doi_str_mv | 10.1093/ndt/gfh741 |
| format | Article |
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Patients with end-stage renal disease have a high risk of premature death, which is due mainly to cardiovascular (CV) events. Elevated cardiac troponin T (cTnT) is related to increased left ventricular mass index (LVMI) and predicts poor outcome in chronic haemodialysis patients. We investigated the prognostic value of cTnT and its relationship with left ventricular mass in continuous ambulatory peritoneal dialysis (CAPD) patients. Methods. Sixty-five CAPD patients (mean age: 56±12 years; 36% males) with no evidence of acute coronary syndrome in 28 days prior to the study were examined prospectively. After 48 months of follow-up, we evaluated total and CV mortality. Results. During follow-up, 23 patients (35%) died (70% CV causes, 22% infection, 4% tumour, 4% unknown). In univariate analysis, concentrations of cTnT ≥0.035 ng/ml, increased LVMI, diabetes, serum albumin and age were all strong predictors of total mortality. In multivariate logistic regression analysis, cTnT ≥0.035 ng/ml and age independently predicted total mortality [odds ratio (OR): 4.31; 95% confidence interval (95% CI): 1.16–16.04; P = 0.008 and OR: 1.08; 95% CI: 1.02–1.15; P = 0.002, respectively]. cTnT level ≥0.035 ng/ml was the only independent predictor of CV mortality in multivariate logistic regression analysis (OR: 8.94; 95% CI: 2.23–35.88; P<0.005). There was a significant positive correlation between serum cTnT level and LVMI (ρ = 0.41; P<0.002). Neither cTnI, CK nor CK-MB were related to total or CV mortality. Conclusions. Elevated serum cTnT but not cTnI predicted total and CV mortality in CAPD patients. Elevated cTnT levels were also associated with increased LVMI.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfh741</identifier><identifier>PMID: 15741207</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cardiovascular Diseases - mortality ; continuous ambulatory peritoneal dialysis ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Glomerulonephritis ; Humans ; Hypertrophy, Left Ventricular - etiology ; Intensive care medicine ; left ventricular hypertrophy ; Male ; Medical sciences ; Middle Aged ; Myocardium - chemistry ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Peritoneal Dialysis, Continuous Ambulatory - adverse effects ; Prognosis ; Prospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; survival ; troponin ; Troponin T - blood</subject><ispartof>Nephrology, dialysis, transplantation, 2005-05, Vol.20 (5), p.962-967</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) May 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-e1f1d6995761356d9b07f65c90a7e91550dfae22d756d6d3681db1929e4107253</citedby><cites>FETCH-LOGICAL-c416t-e1f1d6995761356d9b07f65c90a7e91550dfae22d756d6d3681db1929e4107253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16778931$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15741207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duman, Dursun</creatorcontrib><creatorcontrib>Tokay, Sena</creatorcontrib><creatorcontrib>Toprak, Ahmet</creatorcontrib><creatorcontrib>Duman, Deniz</creatorcontrib><creatorcontrib>Oktay, Ahmet</creatorcontrib><creatorcontrib>Ozener, Ishak Cetin</creatorcontrib><title>Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol. Dial. Transplant</addtitle><description>Background. Patients with end-stage renal disease have a high risk of premature death, which is due mainly to cardiovascular (CV) events. Elevated cardiac troponin T (cTnT) is related to increased left ventricular mass index (LVMI) and predicts poor outcome in chronic haemodialysis patients. We investigated the prognostic value of cTnT and its relationship with left ventricular mass in continuous ambulatory peritoneal dialysis (CAPD) patients. Methods. Sixty-five CAPD patients (mean age: 56±12 years; 36% males) with no evidence of acute coronary syndrome in 28 days prior to the study were examined prospectively. After 48 months of follow-up, we evaluated total and CV mortality. Results. During follow-up, 23 patients (35%) died (70% CV causes, 22% infection, 4% tumour, 4% unknown). In univariate analysis, concentrations of cTnT ≥0.035 ng/ml, increased LVMI, diabetes, serum albumin and age were all strong predictors of total mortality. In multivariate logistic regression analysis, cTnT ≥0.035 ng/ml and age independently predicted total mortality [odds ratio (OR): 4.31; 95% confidence interval (95% CI): 1.16–16.04; P = 0.008 and OR: 1.08; 95% CI: 1.02–1.15; P = 0.002, respectively]. cTnT level ≥0.035 ng/ml was the only independent predictor of CV mortality in multivariate logistic regression analysis (OR: 8.94; 95% CI: 2.23–35.88; P<0.005). There was a significant positive correlation between serum cTnT level and LVMI (ρ = 0.41; P<0.002). Neither cTnI, CK nor CK-MB were related to total or CV mortality. Conclusions. Elevated serum cTnT but not cTnI predicted total and CV mortality in CAPD patients. Elevated cTnT levels were also associated with increased LVMI.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - mortality</subject><subject>continuous ambulatory peritoneal dialysis</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Glomerulonephritis</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Intensive care medicine</subject><subject>left ventricular hypertrophy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardium - chemistry</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Peritoneal Dialysis, Continuous Ambulatory - adverse effects</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>survival</subject><subject>troponin</subject><subject>Troponin T - blood</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0cFu1DAUBVALgehQ2PAByEKCBVKoncT2eIlKYRCV2BRUsbE89gt1SexgO6XzOfwpD2ZEJVZRdE9ernQJecrZa850dxJ9Pfk2XKme3yMr3kvWtN1a3CcrDHnDBNNH5FEp14wx3Sr1kBxxgbhlakV-nY1wYyt46mz2wTpac5pTDJFe0FCoLSW58Bf8DPWKhugy2IKvIwyV3kCsObhltJlOaDH3cEtt9HTO4IOrhU4pVzuGusOQuhRriEta8PS0xe9qyjs6Qw41RbAjxQ7jruCfZ1sDXi-PyYPBjgWeHJ7H5PO7s4vTTXP-6f2H0zfnjeu5rA3wgXuptVCSd0J6vWVqkMJpZhVoLgTzg4W29QpD6Tu55n7Ldauh50y1ojsmL_d355x-LFCqmUJxMI42AtY1UqkeIUf4_D94nZYcsZtp-Zr3vZIa0as9cjmVkmEwcw6TzTvDmfmzmsHVzH41xM8OF5ftBP6OHmZC8OIAbHF2HLKNLpQ7h93WuDW6Zu9CqXD7L7f5O9bvlDCby6_mI3v7ZdNeatN3vwFKdLMb</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Duman, Dursun</creator><creator>Tokay, Sena</creator><creator>Toprak, Ahmet</creator><creator>Duman, Deniz</creator><creator>Oktay, Ahmet</creator><creator>Ozener, Ishak Cetin</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients</title><author>Duman, Dursun ; Tokay, Sena ; Toprak, Ahmet ; Duman, Deniz ; Oktay, Ahmet ; Ozener, Ishak Cetin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-e1f1d6995761356d9b07f65c90a7e91550dfae22d756d6d3681db1929e4107253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Diseases - mortality</topic><topic>continuous ambulatory peritoneal dialysis</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Glomerulonephritis</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Intensive care medicine</topic><topic>left ventricular hypertrophy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardium - chemistry</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Peritoneal Dialysis, Continuous Ambulatory - adverse effects</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>survival</topic><topic>troponin</topic><topic>Troponin T - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duman, Dursun</creatorcontrib><creatorcontrib>Tokay, Sena</creatorcontrib><creatorcontrib>Toprak, Ahmet</creatorcontrib><creatorcontrib>Duman, Deniz</creatorcontrib><creatorcontrib>Oktay, Ahmet</creatorcontrib><creatorcontrib>Ozener, Ishak Cetin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duman, Dursun</au><au>Tokay, Sena</au><au>Toprak, Ahmet</au><au>Duman, Deniz</au><au>Oktay, Ahmet</au><au>Ozener, Ishak Cetin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol. Dial. Transplant</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>20</volume><issue>5</issue><spage>962</spage><epage>967</epage><pages>962-967</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Patients with end-stage renal disease have a high risk of premature death, which is due mainly to cardiovascular (CV) events. Elevated cardiac troponin T (cTnT) is related to increased left ventricular mass index (LVMI) and predicts poor outcome in chronic haemodialysis patients. We investigated the prognostic value of cTnT and its relationship with left ventricular mass in continuous ambulatory peritoneal dialysis (CAPD) patients. Methods. Sixty-five CAPD patients (mean age: 56±12 years; 36% males) with no evidence of acute coronary syndrome in 28 days prior to the study were examined prospectively. After 48 months of follow-up, we evaluated total and CV mortality. Results. During follow-up, 23 patients (35%) died (70% CV causes, 22% infection, 4% tumour, 4% unknown). In univariate analysis, concentrations of cTnT ≥0.035 ng/ml, increased LVMI, diabetes, serum albumin and age were all strong predictors of total mortality. In multivariate logistic regression analysis, cTnT ≥0.035 ng/ml and age independently predicted total mortality [odds ratio (OR): 4.31; 95% confidence interval (95% CI): 1.16–16.04; P = 0.008 and OR: 1.08; 95% CI: 1.02–1.15; P = 0.002, respectively]. cTnT level ≥0.035 ng/ml was the only independent predictor of CV mortality in multivariate logistic regression analysis (OR: 8.94; 95% CI: 2.23–35.88; P<0.005). There was a significant positive correlation between serum cTnT level and LVMI (ρ = 0.41; P<0.002). Neither cTnI, CK nor CK-MB were related to total or CV mortality. Conclusions. Elevated serum cTnT but not cTnI predicted total and CV mortality in CAPD patients. Elevated cTnT levels were also associated with increased LVMI.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15741207</pmid><doi>10.1093/ndt/gfh741</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cardiovascular Diseases - mortality continuous ambulatory peritoneal dialysis Emergency and intensive care: renal failure. Dialysis management Female Glomerulonephritis Humans Hypertrophy, Left Ventricular - etiology Intensive care medicine left ventricular hypertrophy Male Medical sciences Middle Aged Myocardium - chemistry Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Peritoneal Dialysis, Continuous Ambulatory - adverse effects Prognosis Prospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system survival troponin Troponin T - blood |
| title | Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients |
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