Lepidium meyenii (Maca) does not exert direct androgenic activities
Maca is the edible root of the Peruvian plant Lepidum meyenii, traditionally employed for its purported aphrodisiac and fertility-enhancing properties. This study aimed at testing the hypothesis that Maca contains testosterone-like compounds, able to bind the human androgen receptor and promote tran...
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| Veröffentlicht in: | Journal of ethnopharmacology 2006-04, Vol.104 (3), p.415-417 |
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| container_title | Journal of ethnopharmacology |
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| creator | Bogani, P. Simonini, F. Iriti, M. Rossoni, M. Faoro, F. Poletti, A. Visioli, F. |
| description | Maca is the edible root of the Peruvian plant
Lepidum meyenii, traditionally employed for its purported aphrodisiac and fertility-enhancing properties.
This study aimed at testing the hypothesis that Maca contains testosterone-like compounds, able to bind the human androgen receptor and promote transcription pathways regulated by steroid hormone signaling.
Maca extracts (obtained with different solvents: methanol, ethanol, hexane and chloroform) are not able to regulate GRE (glucocorticoid response element) activation. Further experiments are needed to assess which compound, of the several Maca's components, is responsible of the observed in vivo effects. |
| doi_str_mv | 10.1016/j.jep.2005.09.028 |
| format | Article |
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Lepidum meyenii, traditionally employed for its purported aphrodisiac and fertility-enhancing properties.
This study aimed at testing the hypothesis that Maca contains testosterone-like compounds, able to bind the human androgen receptor and promote transcription pathways regulated by steroid hormone signaling.
Maca extracts (obtained with different solvents: methanol, ethanol, hexane and chloroform) are not able to regulate GRE (glucocorticoid response element) activation. Further experiments are needed to assess which compound, of the several Maca's components, is responsible of the observed in vivo effects.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2005.09.028</identifier><identifier>PMID: 16239088</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Androgen receptor ; Androgens - pharmacology ; beta-Galactosidase - biosynthesis ; beta-Galactosidase - genetics ; Biological and medical sciences ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; General pharmacology ; Genes, Reporter ; Glucocorticoids - metabolism ; Humans ; Lepidium ; Lepidium meyenii ; Luciferases - biosynthesis ; Luciferases - genetics ; Maca ; Male ; Medical sciences ; Neoplasms, Hormone-Dependent ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Plant Roots ; Prostatic Neoplasms ; Receptors, Androgen - genetics ; Receptors, Androgen - physiology ; Response Elements</subject><ispartof>Journal of ethnopharmacology, 2006-04, Vol.104 (3), p.415-417</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-28c62424531673f3e165bb0e30f4a59c26ce7ef3b6dda0ba96f7f78e09ea15bf3</citedby><cites>FETCH-LOGICAL-c381t-28c62424531673f3e165bb0e30f4a59c26ce7ef3b6dda0ba96f7f78e09ea15bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2005.09.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17603190$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16239088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bogani, P.</creatorcontrib><creatorcontrib>Simonini, F.</creatorcontrib><creatorcontrib>Iriti, M.</creatorcontrib><creatorcontrib>Rossoni, M.</creatorcontrib><creatorcontrib>Faoro, F.</creatorcontrib><creatorcontrib>Poletti, A.</creatorcontrib><creatorcontrib>Visioli, F.</creatorcontrib><title>Lepidium meyenii (Maca) does not exert direct androgenic activities</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Maca is the edible root of the Peruvian plant
Lepidum meyenii, traditionally employed for its purported aphrodisiac and fertility-enhancing properties.
This study aimed at testing the hypothesis that Maca contains testosterone-like compounds, able to bind the human androgen receptor and promote transcription pathways regulated by steroid hormone signaling.
Maca extracts (obtained with different solvents: methanol, ethanol, hexane and chloroform) are not able to regulate GRE (glucocorticoid response element) activation. Further experiments are needed to assess which compound, of the several Maca's components, is responsible of the observed in vivo effects.</description><subject>Androgen receptor</subject><subject>Androgens - pharmacology</subject><subject>beta-Galactosidase - biosynthesis</subject><subject>beta-Galactosidase - genetics</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Dose-Response Relationship, Drug</subject><subject>General pharmacology</subject><subject>Genes, Reporter</subject><subject>Glucocorticoids - metabolism</subject><subject>Humans</subject><subject>Lepidium</subject><subject>Lepidium meyenii</subject><subject>Luciferases - biosynthesis</subject><subject>Luciferases - genetics</subject><subject>Maca</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasms, Hormone-Dependent</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>Prostatic Neoplasms</subject><subject>Receptors, Androgen - genetics</subject><subject>Receptors, Androgen - physiology</subject><subject>Response Elements</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90D1PwzAQgGELgWgp_AAWlAUEQ8I5TmxHTKjiSypigdlynDNy1CTFTiv670nVSN2YbnnudHoJuaSQUKD8vk5qXCUpQJ5AkUAqj8iUSpHGIhfsmEyBCRlLkdEJOQuhBgBBMzglE8pTVoCUUzJf4MpVbt1EDW6xdS66fddG30VVhyFquz7CX_R9VDmPpo90W_nue3Am0qZ3G9c7DOfkxOplwItxzsjX89Pn_DVefLy8zR8XsWGS9nEqDU-zNMsZ5YJZhpTnZQnIwGY6L0zKDQq0rORVpaHUBbfCColQoKZ5admM3Ozvrnz3s8bQq8YFg8ulbrFbB8WFyCAr5ADpHhrfheDRqpV3jfZbRUHtyqlaDeXUrpyCQg3lhp2r8fi6bLA6bIypBnA9Ah2MXlqvW-PCwQkOjBYwuIe9wyHFxqFXwThsDe4Tqqpz_7zxB7IPixE</recordid><startdate>20060406</startdate><enddate>20060406</enddate><creator>Bogani, P.</creator><creator>Simonini, F.</creator><creator>Iriti, M.</creator><creator>Rossoni, M.</creator><creator>Faoro, F.</creator><creator>Poletti, A.</creator><creator>Visioli, F.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060406</creationdate><title>Lepidium meyenii (Maca) does not exert direct androgenic activities</title><author>Bogani, P. ; Simonini, F. ; Iriti, M. ; Rossoni, M. ; Faoro, F. ; Poletti, A. ; Visioli, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-28c62424531673f3e165bb0e30f4a59c26ce7ef3b6dda0ba96f7f78e09ea15bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Androgen receptor</topic><topic>Androgens - pharmacology</topic><topic>beta-Galactosidase - biosynthesis</topic><topic>beta-Galactosidase - genetics</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Dose-Response Relationship, Drug</topic><topic>General pharmacology</topic><topic>Genes, Reporter</topic><topic>Glucocorticoids - metabolism</topic><topic>Humans</topic><topic>Lepidium</topic><topic>Lepidium meyenii</topic><topic>Luciferases - biosynthesis</topic><topic>Luciferases - genetics</topic><topic>Maca</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasms, Hormone-Dependent</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>Prostatic Neoplasms</topic><topic>Receptors, Androgen - genetics</topic><topic>Receptors, Androgen - physiology</topic><topic>Response Elements</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bogani, P.</creatorcontrib><creatorcontrib>Simonini, F.</creatorcontrib><creatorcontrib>Iriti, M.</creatorcontrib><creatorcontrib>Rossoni, M.</creatorcontrib><creatorcontrib>Faoro, F.</creatorcontrib><creatorcontrib>Poletti, A.</creatorcontrib><creatorcontrib>Visioli, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bogani, P.</au><au>Simonini, F.</au><au>Iriti, M.</au><au>Rossoni, M.</au><au>Faoro, F.</au><au>Poletti, A.</au><au>Visioli, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lepidium meyenii (Maca) does not exert direct androgenic activities</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2006-04-06</date><risdate>2006</risdate><volume>104</volume><issue>3</issue><spage>415</spage><epage>417</epage><pages>415-417</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Maca is the edible root of the Peruvian plant
Lepidum meyenii, traditionally employed for its purported aphrodisiac and fertility-enhancing properties.
This study aimed at testing the hypothesis that Maca contains testosterone-like compounds, able to bind the human androgen receptor and promote transcription pathways regulated by steroid hormone signaling.
Maca extracts (obtained with different solvents: methanol, ethanol, hexane and chloroform) are not able to regulate GRE (glucocorticoid response element) activation. Further experiments are needed to assess which compound, of the several Maca's components, is responsible of the observed in vivo effects.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16239088</pmid><doi>10.1016/j.jep.2005.09.028</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Androgen receptor Androgens - pharmacology beta-Galactosidase - biosynthesis beta-Galactosidase - genetics Biological and medical sciences Cell Line, Tumor Dose-Response Relationship, Drug General pharmacology Genes, Reporter Glucocorticoids - metabolism Humans Lepidium Lepidium meyenii Luciferases - biosynthesis Luciferases - genetics Maca Male Medical sciences Neoplasms, Hormone-Dependent Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plant Roots Prostatic Neoplasms Receptors, Androgen - genetics Receptors, Androgen - physiology Response Elements |
| title | Lepidium meyenii (Maca) does not exert direct androgenic activities |
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