The Structure of a Mixed GluR2 Ligand-binding Core Dimer in Complex with ( S)-Glutamate and the Antagonist ( S)-NS1209

Ionotropic glutamate receptors (iGluRs) mediate fast synaptic transmission between cells of the central nervous system and are involved in various aspects of normal brain function. iGluRs are implicated in several brain disorders, e.g. in the high-frequency discharge of impulses during an epileptic...

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Veröffentlicht in:	Journal of molecular biology 2006-04, Vol.357 (4), p.1184-1201
Hauptverfasser:	Kasper, Christina, Pickering, Darryl S., Mirza, Osman, Olsen, Lars, Kristensen, Anders S., Greenwood, Jeremy R., Liljefors, Tommy, Schousboe, Arne, Wätjen, Frank, Gajhede, Michael, Sigurskjold, Bent W., Kastrup, Jette S.
Format:	Artikel
Sprache:	eng
Schlagworte:	agonist–antagonist complex Animals Binding Sites calorimetry Crystallography, X-Ray Dimerization Excitatory Amino Acid Antagonists - chemistry Excitatory Amino Acid Antagonists - metabolism Glutamic Acid - chemistry Glutamic Acid - metabolism Humans Hydrogen Bonding ionotropic glutamate receptor 2 Macromolecular Substances Models, Molecular Molecular Structure Protein Structure, Quaternary Pyrroles - chemistry Pyrroles - metabolism Quinoxalines - chemistry Quinoxalines - metabolism Rats receptor pharmacology Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - chemistry Receptors, AMPA - genetics Receptors, AMPA - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Tetrahydroisoquinolines - chemistry Tetrahydroisoquinolines - metabolism Thermodynamics X-ray structure
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