Assessment of vasospasm in experimental subarachnoid hemorrhage in rats by selective biplane digital subtraction angiography
Although the rat subarachnoid hemorrhage model is well established in vasospasm research, the angiographic evaluation is difficult due to the animal's small size. For this reason, the aim of the study was to develop a standardized angiographic examination technique without additional complex eq...
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| Veröffentlicht in: | Neuroradiology 2006-03, Vol.48 (3), p.176-181 |
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| creator | WEIDAUER, Stefan VATTER, Hartmut DETTMANN, Edgar SEIFERT, Volker ZANELLA, Friedhelm E |
| description | Although the rat subarachnoid hemorrhage model is well established in vasospasm research, the angiographic evaluation is difficult due to the animal's small size. For this reason, the aim of the study was to develop a standardized angiographic examination technique without additional complex equipment. Under general anesthesia, 11 Sprague-Dawley rats underwent selective cerebral digital subtraction angiography using a 0.3 mm focal spot and a 2.0-fold linear magnification. Five animals had experimental subarachnoid hemorrhage according to the "double-hemorrhage" model. Comparison with the intraarterial tip of the microcatheter enabled calibration of the vessel lumen. The diameter of the normal basilar artery (n=6) was 0.34+/-0.03 mm (mean+/-SD), whereas delayed vasospastic constriction (mean 6.2 days) caused a reduction in diameter of 32.4% (0.23+/-0.09 mm) as well as impaired collateral blood flow via the posterior communicating artery and anterior spinal artery. Histological examination of sections stained with hematoxylin and eosin under a light microscope confirmed vasospasm. In conclusion, biplane digital subtraction angiography allows precise and reliable evaluation of arterial diameter reduction and hemodynamic parameters in a rat vasospasm model. However, further investigation is required for assessment of vasoactive drugs, e.g., endothelin receptor antagonists. |
| doi_str_mv | 10.1007/s00234-005-0021-8 |
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For this reason, the aim of the study was to develop a standardized angiographic examination technique without additional complex equipment. Under general anesthesia, 11 Sprague-Dawley rats underwent selective cerebral digital subtraction angiography using a 0.3 mm focal spot and a 2.0-fold linear magnification. Five animals had experimental subarachnoid hemorrhage according to the "double-hemorrhage" model. Comparison with the intraarterial tip of the microcatheter enabled calibration of the vessel lumen. The diameter of the normal basilar artery (n=6) was 0.34+/-0.03 mm (mean+/-SD), whereas delayed vasospastic constriction (mean 6.2 days) caused a reduction in diameter of 32.4% (0.23+/-0.09 mm) as well as impaired collateral blood flow via the posterior communicating artery and anterior spinal artery. Histological examination of sections stained with hematoxylin and eosin under a light microscope confirmed vasospasm. In conclusion, biplane digital subtraction angiography allows precise and reliable evaluation of arterial diameter reduction and hemodynamic parameters in a rat vasospasm model. However, further investigation is required for assessment of vasoactive drugs, e.g., endothelin receptor antagonists.</description><identifier>ISSN: 0028-3940</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-005-0021-8</identifier><identifier>PMID: 16453117</identifier><identifier>CODEN: NRDYAB</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Anatomy ; Angiography, Digital Subtraction - methods ; Animals ; Biological and medical sciences ; Central nervous system ; Cerebral Angiography - methods ; Disease Models, Animal ; Electrodiagnosis. Electric activity recording ; Fundamental and applied biological sciences. Psychology ; Hemorrhage ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical imaging ; Medical research ; Medical sciences ; Nervous system ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Rodents ; Subarachnoid Hemorrhage - complications ; Vasospasm, Intracranial - diagnostic imaging ; Vasospasm, Intracranial - etiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroradiology, 2006-03, Vol.48 (3), p.176-181</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-fd2127090ad2cb9a61a7a542d1d8b6951256ae5a107d568043bffc8395471fed3</citedby><cites>FETCH-LOGICAL-c356t-fd2127090ad2cb9a61a7a542d1d8b6951256ae5a107d568043bffc8395471fed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17618227$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16453117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WEIDAUER, Stefan</creatorcontrib><creatorcontrib>VATTER, Hartmut</creatorcontrib><creatorcontrib>DETTMANN, Edgar</creatorcontrib><creatorcontrib>SEIFERT, Volker</creatorcontrib><creatorcontrib>ZANELLA, Friedhelm E</creatorcontrib><title>Assessment of vasospasm in experimental subarachnoid hemorrhage in rats by selective biplane digital subtraction angiography</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><description>Although the rat subarachnoid hemorrhage model is well established in vasospasm research, the angiographic evaluation is difficult due to the animal's small size. For this reason, the aim of the study was to develop a standardized angiographic examination technique without additional complex equipment. Under general anesthesia, 11 Sprague-Dawley rats underwent selective cerebral digital subtraction angiography using a 0.3 mm focal spot and a 2.0-fold linear magnification. Five animals had experimental subarachnoid hemorrhage according to the "double-hemorrhage" model. Comparison with the intraarterial tip of the microcatheter enabled calibration of the vessel lumen. The diameter of the normal basilar artery (n=6) was 0.34+/-0.03 mm (mean+/-SD), whereas delayed vasospastic constriction (mean 6.2 days) caused a reduction in diameter of 32.4% (0.23+/-0.09 mm) as well as impaired collateral blood flow via the posterior communicating artery and anterior spinal artery. Histological examination of sections stained with hematoxylin and eosin under a light microscope confirmed vasospasm. In conclusion, biplane digital subtraction angiography allows precise and reliable evaluation of arterial diameter reduction and hemodynamic parameters in a rat vasospasm model. However, further investigation is required for assessment of vasoactive drugs, e.g., endothelin receptor antagonists.</description><subject>Anatomy</subject><subject>Angiography, Digital Subtraction - methods</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Cerebral Angiography - methods</subject><subject>Disease Models, Animal</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemorrhage</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproducibility of Results</subject><subject>Rodents</subject><subject>Subarachnoid Hemorrhage - complications</subject><subject>Vasospasm, Intracranial - diagnostic imaging</subject><subject>Vasospasm, Intracranial - etiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0028-3940</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU2L1TAUhoMoznX0B7iRIOiumpM0TbscBr9gwI2uw2mT3puhbWpOO8wFf7wptzDgIgSS5305nIextyA-gRDmMwkhVVkIofORUNTP2AFKJQtopHjODvmxLlRTiiv2iuheCKGMMi_ZFVSlVgDmwP7eEHmi0U8Ljz1_QIo0I408TNw_zj6F7QsHTmuLCbvTFIPjJz_GlE549BuXcCHenjn5wXdLePC8DfOAk-cuHMMeXnJ4CXHiOB1DPCacT-fX7EWPA_k3-33Nfn_98uv2e3H389uP25u7olO6WoreSZBGNAKd7NoGK0CDupQOXN1WjQapK_QaQRinq1qUqu37rlaNLg303qlr9vHSO6f4Z_W02DFQ54dtxriSrYxRjdB1Bt__B97HNU15NislgNbQ6AzBBepSJEq-t3PeEqazBWE3L_bixWYvdvNit-J3e_Hajt49JXYRGfiwA0gdDn3CqQv0xJkKaimN-gegK5d9</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>WEIDAUER, Stefan</creator><creator>VATTER, Hartmut</creator><creator>DETTMANN, Edgar</creator><creator>SEIFERT, Volker</creator><creator>ZANELLA, Friedhelm E</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Assessment of vasospasm in experimental subarachnoid hemorrhage in rats by selective biplane digital subtraction angiography</title><author>WEIDAUER, Stefan ; VATTER, Hartmut ; DETTMANN, Edgar ; SEIFERT, Volker ; ZANELLA, Friedhelm E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-fd2127090ad2cb9a61a7a542d1d8b6951256ae5a107d568043bffc8395471fed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anatomy</topic><topic>Angiography, Digital Subtraction - methods</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Cerebral Angiography - methods</topic><topic>Disease Models, Animal</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemorrhage</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproducibility of Results</topic><topic>Rodents</topic><topic>Subarachnoid Hemorrhage - complications</topic><topic>Vasospasm, Intracranial - diagnostic imaging</topic><topic>Vasospasm, Intracranial - etiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEIDAUER, Stefan</creatorcontrib><creatorcontrib>VATTER, Hartmut</creatorcontrib><creatorcontrib>DETTMANN, Edgar</creatorcontrib><creatorcontrib>SEIFERT, Volker</creatorcontrib><creatorcontrib>ZANELLA, Friedhelm E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WEIDAUER, Stefan</au><au>VATTER, Hartmut</au><au>DETTMANN, Edgar</au><au>SEIFERT, Volker</au><au>ZANELLA, Friedhelm E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of vasospasm in experimental subarachnoid hemorrhage in rats by selective biplane digital subtraction angiography</atitle><jtitle>Neuroradiology</jtitle><addtitle>Neuroradiology</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>48</volume><issue>3</issue><spage>176</spage><epage>181</epage><pages>176-181</pages><issn>0028-3940</issn><eissn>1432-1920</eissn><coden>NRDYAB</coden><abstract>Although the rat subarachnoid hemorrhage model is well established in vasospasm research, the angiographic evaluation is difficult due to the animal's small size. For this reason, the aim of the study was to develop a standardized angiographic examination technique without additional complex equipment. Under general anesthesia, 11 Sprague-Dawley rats underwent selective cerebral digital subtraction angiography using a 0.3 mm focal spot and a 2.0-fold linear magnification. Five animals had experimental subarachnoid hemorrhage according to the "double-hemorrhage" model. Comparison with the intraarterial tip of the microcatheter enabled calibration of the vessel lumen. The diameter of the normal basilar artery (n=6) was 0.34+/-0.03 mm (mean+/-SD), whereas delayed vasospastic constriction (mean 6.2 days) caused a reduction in diameter of 32.4% (0.23+/-0.09 mm) as well as impaired collateral blood flow via the posterior communicating artery and anterior spinal artery. Histological examination of sections stained with hematoxylin and eosin under a light microscope confirmed vasospasm. In conclusion, biplane digital subtraction angiography allows precise and reliable evaluation of arterial diameter reduction and hemodynamic parameters in a rat vasospasm model. However, further investigation is required for assessment of vasoactive drugs, e.g., endothelin receptor antagonists.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16453117</pmid><doi>10.1007/s00234-005-0021-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Anatomy Angiography, Digital Subtraction - methods Animals Biological and medical sciences Central nervous system Cerebral Angiography - methods Disease Models, Animal Electrodiagnosis. Electric activity recording Fundamental and applied biological sciences. Psychology Hemorrhage Investigative techniques, diagnostic techniques (general aspects) Male Medical imaging Medical research Medical sciences Nervous system Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Sprague-Dawley Reproducibility of Results Rodents Subarachnoid Hemorrhage - complications Vasospasm, Intracranial - diagnostic imaging Vasospasm, Intracranial - etiology Vertebrates: nervous system and sense organs |
| title | Assessment of vasospasm in experimental subarachnoid hemorrhage in rats by selective biplane digital subtraction angiography |
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