The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion

PTEN is frequently inactivated during the development of many cancers, including prostate cancer, and both bi‐allelic and mono‐allelic PTEN inactivation may contribute to tumorigenesis. PTEN mutations in clinical cancer specimens can easily be recorded but mono‐ or bi‐allelic gene deletions are ofte...

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Veröffentlicht in:	The Journal of pathology 2006-04, Vol.208 (5), p.699-707
Hauptverfasser:	Verhagen, PCMS, van Duijn, PW, Hermans, KGL, Looijenga, LHJ, van Gurp, RJHLM, Stoop, H, van der Kwast, TH, Trapman, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosomes, Human, Pair 10 - genetics Disease Progression DNA, Neoplasm - genetics Gene Deletion Gene Silencing Humans In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Nephrology. Urinary tract diseases Nucleic Acid Hybridization - methods Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase Chain Reaction - methods Polymorphism, Single-Stranded Conformational prostate neoplasm Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism PTEN PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Tumors of the urinary system tumour suppressor gene Urinary tract. Prostate gland
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