Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptors

In this study we have studied decavanadate effects at P2X receptors. Decavanadate competitively blocked 2'- and 3'-O-(4benzoylbenzoyl) ATP (BzATP) stimulated ethidium accumulation in HEK293 cells expressing human recombinant P2X7 receptors (pK(B) 7.5). The effects of decavanadate were rapi...

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Veröffentlicht in:	European journal of pharmacology 2006-03, Vol.534 (1-3), p.19-29
Hauptverfasser:	MICHEL, Anton D, MENGLE XING, THOMPSON, Kyla M, JONES, Clare A, HUMPHREY, Patrick P. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium Signaling - drug effects Cell Line Dose-Response Relationship, Drug Humans Kinetics Ligands Medical sciences Membrane Potentials - drug effects Pharmacology. Drug treatments Purinergic P2 Receptor Antagonists Pyridoxal Phosphate - pharmacology Receptors, Purinergic P2 - genetics Receptors, Purinergic P2X2 Receptors, Purinergic P2X4 Receptors, Purinergic P2X7 Rosaniline Dyes - pharmacology Transfection Vanadates - pharmacology
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