Rewarding properties of sildenafil citrate in mice : role of the nitric oxide-cyclic GMP pathway

Sildenafil citrate is widely prescribed for erectile dysfunction and acts by inhibiting phosphodiesterase type-5, resulting in accumulation of cyclic-guanosine monophosphate (cGMP) via activation of nitric oxide synthase (NOS). The nitric oxide (NO) system is relevant to the rewarding effects of var...

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Veröffentlicht in:	Psychopharmacologia 2006-04, Vol.185 (2), p.201-207
Hauptverfasser:	TAHSILI-FAHADAN, Pouya, YAHYAVI-FIROUZ-ABADI, Noushin, AMIR HOSSEIN ORANDI, ESMAEILI, Behnaz, BASSEDA, Zahra, AHMAD REZA DEHPOUR
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - pharmacology Biological and medical sciences Conditioning (Psychology) - drug effects Cyclic GMP - metabolism Dose-Response Relationship, Drug Drugs Erectile dysfunction FDA approval Guanylate Cyclase - antagonists & inhibitors HIV Human immunodeficiency virus Hypotheses Male Medical sciences Methamphetamine Methylene Blue - pharmacology Mice NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Penis Phosphodiesterase Inhibitors - pharmacology Piperazines - pharmacology Purines Reward Sildenafil Citrate Sulfones
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