In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa
The effect of Nigella sativa (NS) L. oil (blackseed oil) on the fibrinolytic system of the human umbilical vein (HUV) and human uterine arterial (HUA) endothelial cells (ECs) in culture was studied. Both of them showed a concentration-dependent increase in tissue-type plasminogen activator (t-PA). A...
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| creator | Awad, E.M. Binder, B.R. |
| description | The effect of
Nigella sativa (NS) L. oil (blackseed oil) on the fibrinolytic system of the human umbilical vein (HUV) and human uterine arterial (HUA) endothelial cells (ECs) in culture was studied. Both of them showed a concentration-dependent increase in tissue-type plasminogen activator (t-PA). A maximum effect was achieved with 50
μg oil/ml conditioned medium (CM) (1.3±0.15
ng/10
4 cells/24
h vs. control 0.7±0.06
ng/10
4 cells/24
h, and 0.38±0.04
ng/10
4 cells/24
h vs. control 0.24±0.02
ng/10
4 cells/24
h, for HUVEC and HUA-EC, respectively). At 100
μg/ml, there was a significant change in the amount of t-PA antigen produced by either HUVEC or HUA-EC (1.0±0.1
ng/10
4 cells/24
h or 0.28±0.02
ng/10
4 cells/24
h) as compared to control CM from cells grown under control conditions, but still less than that recorded at 50
μg oil/ml. Plasminogen activator inhibitor-type 1 increased the CM significantly and concentration-dependently in both cells. For HUVEC, the maximum effect was achieved at a concentration of 100
μg/ml (257.7±8.0
ng/10
4 cells/24
h vs. control 72.7±3.8
ng/10
4 cells/24
h). HUA-EC showed the maximum effect at a concentration of 100
μg/ml (171.6±4.4
ng/10
4 cells/24
h vs. control 53.8±3.7
ng/10
4 cells/24
h). This study suggests a role for NS oil in modulating the balance of fibrinolysis/thrombus formation by modulating the fibrinolytic potential of endothelial cells. |
| doi_str_mv | 10.1016/j.phymed.2003.09.008 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67737260</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A133644493</galeid><els_id>S0944711304001011</els_id><sourcerecordid>A133644493</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-ac441c80fee137fd2f6ca957a9ecd458e05f8bebbbe684bd701fcb34cb59c9b03</originalsourceid><addsrcrecordid>eNp90V2L1DAUBuAgijuu_gPRouBd60mTfuRGWBY_FhZFdMG7kKQnsxk6yWzSGZh_b0oHQRkkF4HkOYeTvIS8pFBRoO37TbW7P25xqGoAVoGoAPpHZEVb2pcgml-PyQoE52VHKbsgz1LaAFAuOnhKLmjTM-g5XZHvN744uCmGwvlhbyYXfBFsgX4I0z2OTo2FwXEsrNPR-TAeJ2cKNU4Y1WxToY_FV7fORBUpHx3Uc_LEqjHhi9N-Se4-ffx5_aW8_fb55vrqtjQNbadSGc6p6cEiUtbZobatUaLplEAz8KZHaGyvUWuNbc_10AG1RjNudCOM0MAuybul7y6Ghz2mSW5dmmdVHsM-ybbrWFe3M3zzD9yEffR5NllD0zDG-jqjtwtaqxGl8zZMUZm5o7yijLWcc8GyKs-oNfr8HWPwaF0-_stXZ3xeA26dOVvAlwITQ0oRrdxFt1XxKCnIOXa5kUvsco5dgpA59lz26vTEvZ7v_hSdcs7g9QKsClKto0vy7kcNlEFuCn3dZfFhEZgzOziMMhmH3uDgIppJDsH9f4bfApvIjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205533382</pqid></control><display><type>article</type><title>In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Awad, E.M. ; Binder, B.R.</creator><creatorcontrib>Awad, E.M. ; Binder, B.R.</creatorcontrib><description>The effect of
Nigella sativa (NS) L. oil (blackseed oil) on the fibrinolytic system of the human umbilical vein (HUV) and human uterine arterial (HUA) endothelial cells (ECs) in culture was studied. Both of them showed a concentration-dependent increase in tissue-type plasminogen activator (t-PA). A maximum effect was achieved with 50
μg oil/ml conditioned medium (CM) (1.3±0.15
ng/10
4 cells/24
h vs. control 0.7±0.06
ng/10
4 cells/24
h, and 0.38±0.04
ng/10
4 cells/24
h vs. control 0.24±0.02
ng/10
4 cells/24
h, for HUVEC and HUA-EC, respectively). At 100
μg/ml, there was a significant change in the amount of t-PA antigen produced by either HUVEC or HUA-EC (1.0±0.1
ng/10
4 cells/24
h or 0.28±0.02
ng/10
4 cells/24
h) as compared to control CM from cells grown under control conditions, but still less than that recorded at 50
μg oil/ml. Plasminogen activator inhibitor-type 1 increased the CM significantly and concentration-dependently in both cells. For HUVEC, the maximum effect was achieved at a concentration of 100
μg/ml (257.7±8.0
ng/10
4 cells/24
h vs. control 72.7±3.8
ng/10
4 cells/24
h). HUA-EC showed the maximum effect at a concentration of 100
μg/ml (171.6±4.4
ng/10
4 cells/24
h vs. control 53.8±3.7
ng/10
4 cells/24
h). This study suggests a role for NS oil in modulating the balance of fibrinolysis/thrombus formation by modulating the fibrinolytic potential of endothelial cells.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2003.09.008</identifier><identifier>PMID: 15830841</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacology ; Antineoplastic Agents, Phytogenic - therapeutic use ; arteries ; Arteries - cytology ; blood veins ; Cell Line, Tumor - drug effects ; cell lines ; Dose-Response Relationship, Drug ; Endothelial cells ; Endothelial growth factors ; endothelium ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; enzyme inhibitors ; Female ; fibrinolysis ; Fibrinolysis - drug effects ; Fibrinolytic system ; Health aspects ; herbal medicines ; Humans ; medicinal plants ; medicinal properties ; Nigella sativa ; PAI-1 ; Phytotherapy ; Plant Oils - administration & dosage ; Plant Oils - pharmacology ; Plant Oils - therapeutic use ; Plasminogen Activator Inhibitor 1 - metabolism ; Ranunculaceae ; seed oils ; t-PA ; t-plasminogen activator ; Thrombolytic drugs ; Tissue Plasminogen Activator - metabolism ; Umbilical Veins - cytology ; Uterus - blood supply</subject><ispartof>Phytomedicine (Stuttgart), 2005-03, Vol.12 (3), p.194-202</ispartof><rights>2004</rights><rights>COPYRIGHT 2005 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag Mar 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-ac441c80fee137fd2f6ca957a9ecd458e05f8bebbbe684bd701fcb34cb59c9b03</citedby><cites>FETCH-LOGICAL-c516t-ac441c80fee137fd2f6ca957a9ecd458e05f8bebbbe684bd701fcb34cb59c9b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711304001011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15830841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awad, E.M.</creatorcontrib><creatorcontrib>Binder, B.R.</creatorcontrib><title>In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>The effect of
Nigella sativa (NS) L. oil (blackseed oil) on the fibrinolytic system of the human umbilical vein (HUV) and human uterine arterial (HUA) endothelial cells (ECs) in culture was studied. Both of them showed a concentration-dependent increase in tissue-type plasminogen activator (t-PA). A maximum effect was achieved with 50
μg oil/ml conditioned medium (CM) (1.3±0.15
ng/10
4 cells/24
h vs. control 0.7±0.06
ng/10
4 cells/24
h, and 0.38±0.04
ng/10
4 cells/24
h vs. control 0.24±0.02
ng/10
4 cells/24
h, for HUVEC and HUA-EC, respectively). At 100
μg/ml, there was a significant change in the amount of t-PA antigen produced by either HUVEC or HUA-EC (1.0±0.1
ng/10
4 cells/24
h or 0.28±0.02
ng/10
4 cells/24
h) as compared to control CM from cells grown under control conditions, but still less than that recorded at 50
μg oil/ml. Plasminogen activator inhibitor-type 1 increased the CM significantly and concentration-dependently in both cells. For HUVEC, the maximum effect was achieved at a concentration of 100
μg/ml (257.7±8.0
ng/10
4 cells/24
h vs. control 72.7±3.8
ng/10
4 cells/24
h). HUA-EC showed the maximum effect at a concentration of 100
μg/ml (171.6±4.4
ng/10
4 cells/24
h vs. control 53.8±3.7
ng/10
4 cells/24
h). This study suggests a role for NS oil in modulating the balance of fibrinolysis/thrombus formation by modulating the fibrinolytic potential of endothelial cells.</description><subject>Adult</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>arteries</subject><subject>Arteries - cytology</subject><subject>blood veins</subject><subject>Cell Line, Tumor - drug effects</subject><subject>cell lines</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelial cells</subject><subject>Endothelial growth factors</subject><subject>endothelium</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>enzyme inhibitors</subject><subject>Female</subject><subject>fibrinolysis</subject><subject>Fibrinolysis - drug effects</subject><subject>Fibrinolytic system</subject><subject>Health aspects</subject><subject>herbal medicines</subject><subject>Humans</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Nigella sativa</subject><subject>PAI-1</subject><subject>Phytotherapy</subject><subject>Plant Oils - administration & dosage</subject><subject>Plant Oils - pharmacology</subject><subject>Plant Oils - therapeutic use</subject><subject>Plasminogen Activator Inhibitor 1 - metabolism</subject><subject>Ranunculaceae</subject><subject>seed oils</subject><subject>t-PA</subject><subject>t-plasminogen activator</subject><subject>Thrombolytic drugs</subject><subject>Tissue Plasminogen Activator - metabolism</subject><subject>Umbilical Veins - cytology</subject><subject>Uterus - blood supply</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90V2L1DAUBuAgijuu_gPRouBd60mTfuRGWBY_FhZFdMG7kKQnsxk6yWzSGZh_b0oHQRkkF4HkOYeTvIS8pFBRoO37TbW7P25xqGoAVoGoAPpHZEVb2pcgml-PyQoE52VHKbsgz1LaAFAuOnhKLmjTM-g5XZHvN744uCmGwvlhbyYXfBFsgX4I0z2OTo2FwXEsrNPR-TAeJ2cKNU4Y1WxToY_FV7fORBUpHx3Uc_LEqjHhi9N-Se4-ffx5_aW8_fb55vrqtjQNbadSGc6p6cEiUtbZobatUaLplEAz8KZHaGyvUWuNbc_10AG1RjNudCOM0MAuybul7y6Ghz2mSW5dmmdVHsM-ybbrWFe3M3zzD9yEffR5NllD0zDG-jqjtwtaqxGl8zZMUZm5o7yijLWcc8GyKs-oNfr8HWPwaF0-_stXZ3xeA26dOVvAlwITQ0oRrdxFt1XxKCnIOXa5kUvsco5dgpA59lz26vTEvZ7v_hSdcs7g9QKsClKto0vy7kcNlEFuCn3dZfFhEZgzOziMMhmH3uDgIppJDsH9f4bfApvIjA</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Awad, E.M.</creator><creator>Binder, B.R.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><general>Elsevier Science Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa</title><author>Awad, E.M. ; Binder, B.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-ac441c80fee137fd2f6ca957a9ecd458e05f8bebbbe684bd701fcb34cb59c9b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>arteries</topic><topic>Arteries - cytology</topic><topic>blood veins</topic><topic>Cell Line, Tumor - drug effects</topic><topic>cell lines</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelial cells</topic><topic>Endothelial growth factors</topic><topic>endothelium</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - drug effects</topic><topic>enzyme inhibitors</topic><topic>Female</topic><topic>fibrinolysis</topic><topic>Fibrinolysis - drug effects</topic><topic>Fibrinolytic system</topic><topic>Health aspects</topic><topic>herbal medicines</topic><topic>Humans</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Nigella sativa</topic><topic>PAI-1</topic><topic>Phytotherapy</topic><topic>Plant Oils - administration & dosage</topic><topic>Plant Oils - pharmacology</topic><topic>Plant Oils - therapeutic use</topic><topic>Plasminogen Activator Inhibitor 1 - metabolism</topic><topic>Ranunculaceae</topic><topic>seed oils</topic><topic>t-PA</topic><topic>t-plasminogen activator</topic><topic>Thrombolytic drugs</topic><topic>Tissue Plasminogen Activator - metabolism</topic><topic>Umbilical Veins - cytology</topic><topic>Uterus - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awad, E.M.</creatorcontrib><creatorcontrib>Binder, B.R.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awad, E.M.</au><au>Binder, B.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>12</volume><issue>3</issue><spage>194</spage><epage>202</epage><pages>194-202</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>The effect of
Nigella sativa (NS) L. oil (blackseed oil) on the fibrinolytic system of the human umbilical vein (HUV) and human uterine arterial (HUA) endothelial cells (ECs) in culture was studied. Both of them showed a concentration-dependent increase in tissue-type plasminogen activator (t-PA). A maximum effect was achieved with 50
μg oil/ml conditioned medium (CM) (1.3±0.15
ng/10
4 cells/24
h vs. control 0.7±0.06
ng/10
4 cells/24
h, and 0.38±0.04
ng/10
4 cells/24
h vs. control 0.24±0.02
ng/10
4 cells/24
h, for HUVEC and HUA-EC, respectively). At 100
μg/ml, there was a significant change in the amount of t-PA antigen produced by either HUVEC or HUA-EC (1.0±0.1
ng/10
4 cells/24
h or 0.28±0.02
ng/10
4 cells/24
h) as compared to control CM from cells grown under control conditions, but still less than that recorded at 50
μg oil/ml. Plasminogen activator inhibitor-type 1 increased the CM significantly and concentration-dependently in both cells. For HUVEC, the maximum effect was achieved at a concentration of 100
μg/ml (257.7±8.0
ng/10
4 cells/24
h vs. control 72.7±3.8
ng/10
4 cells/24
h). HUA-EC showed the maximum effect at a concentration of 100
μg/ml (171.6±4.4
ng/10
4 cells/24
h vs. control 53.8±3.7
ng/10
4 cells/24
h). This study suggests a role for NS oil in modulating the balance of fibrinolysis/thrombus formation by modulating the fibrinolytic potential of endothelial cells.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>15830841</pmid><doi>10.1016/j.phymed.2003.09.008</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2005-03, Vol.12 (3), p.194-202 |
| issn | 0944-7113 1618-095X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67737260 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use arteries Arteries - cytology blood veins Cell Line, Tumor - drug effects cell lines Dose-Response Relationship, Drug Endothelial cells Endothelial growth factors endothelium Endothelium, Vascular - cytology Endothelium, Vascular - drug effects enzyme inhibitors Female fibrinolysis Fibrinolysis - drug effects Fibrinolytic system Health aspects herbal medicines Humans medicinal plants medicinal properties Nigella sativa PAI-1 Phytotherapy Plant Oils - administration & dosage Plant Oils - pharmacology Plant Oils - therapeutic use Plasminogen Activator Inhibitor 1 - metabolism Ranunculaceae seed oils t-PA t-plasminogen activator Thrombolytic drugs Tissue Plasminogen Activator - metabolism Umbilical Veins - cytology Uterus - blood supply |
| title | In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa |
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