Superselective intraarterial chemotherapy using low dose CBDCA and Pirarubicin with concurrent radiotherapy for head and neck cancer
To study the effects of superselective intraarterial chemotherapy with low-dose CBDCA, Pirarubicin, and concurrent radiotherapy on head and neck cancer, we compared primary cancer response and histopathological effective grades in 66 patients (more than T2) divided into radical and preoperative radi...
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| Veröffentlicht in: | Nippon Jibi Inkoka Gakkai Kaiho 2005-03, Vol.108 (3), p.195-201 |
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| container_title | Nippon Jibi Inkoka Gakkai Kaiho |
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| creator | Ito, Kazuyuki Shiba, Hiromi Fujiwara, Kazunori Kunimoto, Yasuomi Tanimoto, Shunji Higami, Yumiko Kitano, Hiroya |
| description | To study the effects of superselective intraarterial chemotherapy with low-dose CBDCA, Pirarubicin, and concurrent radiotherapy on head and neck cancer, we compared primary cancer response and histopathological effective grades in 66 patients (more than T2) divided into radical and preoperative radiotherapy groups. The radical group (n=33) showed a 75.7% response in primary cancer, i.e. 54.5% complete remission and 21.2% partial remission. The preoperative group (n = 33) showed 39.4% complete remission when the histopathological effective grade was higher, and 57.6% partial remission when the grade was lower. Cancer response was better in the oral cavity, mesopharynx, and hypopharynx than in the parasinus. In the preoperative group, 5-year overall survival was 84.4% when the effective grade was higher, and 29.4% when the grade was lower. Survival differed significantly (P |
| doi_str_mv | 10.3950/jibiinkoka.108.195 |
| format | Article |
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The radical group (n=33) showed a 75.7% response in primary cancer, i.e. 54.5% complete remission and 21.2% partial remission. The preoperative group (n = 33) showed 39.4% complete remission when the histopathological effective grade was higher, and 57.6% partial remission when the grade was lower. Cancer response was better in the oral cavity, mesopharynx, and hypopharynx than in the parasinus. In the preoperative group, 5-year overall survival was 84.4% when the effective grade was higher, and 29.4% when the grade was lower. Survival differed significantly (P<0.01) between higher and lower grades. 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The radical group (n=33) showed a 75.7% response in primary cancer, i.e. 54.5% complete remission and 21.2% partial remission. The preoperative group (n = 33) showed 39.4% complete remission when the histopathological effective grade was higher, and 57.6% partial remission when the grade was lower. Cancer response was better in the oral cavity, mesopharynx, and hypopharynx than in the parasinus. In the preoperative group, 5-year overall survival was 84.4% when the effective grade was higher, and 29.4% when the grade was lower. Survival differed significantly (P<0.01) between higher and lower grades. Additional postoperative therapy is thus essential in patients with lower grades of histopathological effectiveness.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Carboplatin - administration & dosage</subject><subject>Combined Modality Therapy</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - analogs & derivatives</subject><subject>Female</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Infusions, Intra-Arterial</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiotherapy Dosage</subject><subject>Remission Induction</subject><subject>Survival Rate</subject><issn>0030-6622</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAYhD2AaFX6BxiQJ7YUf8ROMpbwKSGBBMyRY78hblMn2A5Vd344FRR0wy13j3SH0BklC14IcrmytbVu3a_VgpJ8QQtxhKaEcJJIydgEzUOwNSGkSAln5ARNqMjZXukUfb2MA_gAHehoPwFbF71SPoK3qsO6hU0fW_Bq2OExWPeOu36LTR8Al1fX5RIrZ_Cz9cqPtdXW4a2NLda906P34CL2yth_QtN73IIyPy0Heo21chr8KTpuVBdgfvAZeru9eS3vk8enu4dy-ZisaE5jAnVWc0oyoSXXUlDNGy2YyTU3-61NA5RwyUjG0lSkRUGVyEXB8joviCF1I_kMXfxyB99_jBBitbFBQ9cpB_0YKpllXOYs2wfPD8Gx3oCpBm83yu-qv9_4N4WLcnI</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Ito, Kazuyuki</creator><creator>Shiba, Hiromi</creator><creator>Fujiwara, Kazunori</creator><creator>Kunimoto, Yasuomi</creator><creator>Tanimoto, Shunji</creator><creator>Higami, Yumiko</creator><creator>Kitano, Hiroya</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200503</creationdate><title>Superselective intraarterial chemotherapy using low dose CBDCA and Pirarubicin with concurrent radiotherapy for head and neck cancer</title><author>Ito, Kazuyuki ; Shiba, Hiromi ; Fujiwara, Kazunori ; Kunimoto, Yasuomi ; Tanimoto, Shunji ; Higami, Yumiko ; Kitano, Hiroya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j181t-eb7b31075c63c651c3fc52d8c3d030ffe103620724454991a585928b890d0bf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Carboplatin - administration & dosage</topic><topic>Combined Modality Therapy</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - analogs & derivatives</topic><topic>Female</topic><topic>Head and Neck Neoplasms - drug therapy</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Infusions, Intra-Arterial</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radiotherapy Dosage</topic><topic>Remission Induction</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Kazuyuki</creatorcontrib><creatorcontrib>Shiba, Hiromi</creatorcontrib><creatorcontrib>Fujiwara, Kazunori</creatorcontrib><creatorcontrib>Kunimoto, Yasuomi</creatorcontrib><creatorcontrib>Tanimoto, Shunji</creatorcontrib><creatorcontrib>Higami, Yumiko</creatorcontrib><creatorcontrib>Kitano, Hiroya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Jibi Inkoka Gakkai Kaiho</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Kazuyuki</au><au>Shiba, Hiromi</au><au>Fujiwara, Kazunori</au><au>Kunimoto, Yasuomi</au><au>Tanimoto, Shunji</au><au>Higami, Yumiko</au><au>Kitano, Hiroya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Superselective intraarterial chemotherapy using low dose CBDCA and Pirarubicin with concurrent radiotherapy for head and neck cancer</atitle><jtitle>Nippon Jibi Inkoka Gakkai Kaiho</jtitle><addtitle>Nihon Jibiinkoka Gakkai Kaiho</addtitle><date>2005-03</date><risdate>2005</risdate><volume>108</volume><issue>3</issue><spage>195</spage><epage>201</epage><pages>195-201</pages><issn>0030-6622</issn><abstract>To study the effects of superselective intraarterial chemotherapy with low-dose CBDCA, Pirarubicin, and concurrent radiotherapy on head and neck cancer, we compared primary cancer response and histopathological effective grades in 66 patients (more than T2) divided into radical and preoperative radiotherapy groups. The radical group (n=33) showed a 75.7% response in primary cancer, i.e. 54.5% complete remission and 21.2% partial remission. The preoperative group (n = 33) showed 39.4% complete remission when the histopathological effective grade was higher, and 57.6% partial remission when the grade was lower. Cancer response was better in the oral cavity, mesopharynx, and hypopharynx than in the parasinus. In the preoperative group, 5-year overall survival was 84.4% when the effective grade was higher, and 29.4% when the grade was lower. Survival differed significantly (P<0.01) between higher and lower grades. Additional postoperative therapy is thus essential in patients with lower grades of histopathological effectiveness.</abstract><cop>Japan</cop><pmid>15828284</pmid><doi>10.3950/jibiinkoka.108.195</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carboplatin - administration & dosage Combined Modality Therapy Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Female Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy Humans Infusions, Intra-Arterial Male Middle Aged Radiotherapy Dosage Remission Induction Survival Rate |
| title | Superselective intraarterial chemotherapy using low dose CBDCA and Pirarubicin with concurrent radiotherapy for head and neck cancer |
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