Biocompatibility and Fatigue Properties of Polystyrene−Polyisobutylene−Polystyrene, an Emerging Thermoplastic Elastomeric Biomaterial
This paper will discuss the biocompatibility and dynamic fatigue properties of polystyrene-b-polyisobutylene-b-polystyrene thermoplastic elastomer with 30 wt % polystyrene (SIBS30), an emerging FDA-approved biomaterial. SIBS30 is a very soft, transparent biomaterial resembling silicone rubber, with...
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| Veröffentlicht in: | Biomacromolecules 2006-03, Vol.7 (3), p.844-850 |
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| creator | El Fray, Miroslawa Prowans, Piotr Puskas, Judit E Altstädt, Volker |
| description | This paper will discuss the biocompatibility and dynamic fatigue properties of polystyrene-b-polyisobutylene-b-polystyrene thermoplastic elastomer with 30 wt % polystyrene (SIBS30), an emerging FDA-approved biomaterial. SIBS30 is a very soft, transparent biomaterial resembling silicone rubber, with superior mechanical properties. Using the hysteresis method adopted for soft biomaterials, the dynamic fatigue properties of SIBS30 were found to be between those of polyurethane and silicone rubber, with fatigue life twice as long as that of silicone. Under single load testing (SLT, 1.25 MPa), SIBS30 displayed less than half the dynamic creep compared to silicone, both in air and in vitro (37 °C, simulated body fluid). Hemolysis and 30- and 180-day implantation studies revealed excellent biocompatibility of the new biomaterial. The results presented in this paper indicate that, in comparison with silicone rubber, SIBS30 has similar biocompatibility and superior dynamic fatigue properties. |
| doi_str_mv | 10.1021/bm050971c |
| format | Article |
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SIBS30 is a very soft, transparent biomaterial resembling silicone rubber, with superior mechanical properties. Using the hysteresis method adopted for soft biomaterials, the dynamic fatigue properties of SIBS30 were found to be between those of polyurethane and silicone rubber, with fatigue life twice as long as that of silicone. Under single load testing (SLT, 1.25 MPa), SIBS30 displayed less than half the dynamic creep compared to silicone, both in air and in vitro (37 °C, simulated body fluid). Hemolysis and 30- and 180-day implantation studies revealed excellent biocompatibility of the new biomaterial. The results presented in this paper indicate that, in comparison with silicone rubber, SIBS30 has similar biocompatibility and superior dynamic fatigue properties.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm050971c</identifier><identifier>PMID: 16529422</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Applied sciences ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Biological properties ; Elasticity ; Exact sciences and technology ; Hemolysis ; Hot Temperature ; Humans ; Materials Testing - instrumentation ; Medical sciences ; Models, Chemical ; Models, Molecular ; Organic polymers ; Physicochemistry of polymers ; Properties and characterization ; Sheep ; Silicones - chemistry ; Styrenes - chemistry ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Tensile Strength</subject><ispartof>Biomacromolecules, 2006-03, Vol.7 (3), p.844-850</ispartof><rights>Copyright © 2006 American Chemical Society</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a343t-9c4d523ca016000aaa7e6dfa8ae8ae119df5e3ccf95a31444b9ada079f4243c53</citedby><cites>FETCH-LOGICAL-a343t-9c4d523ca016000aaa7e6dfa8ae8ae119df5e3ccf95a31444b9ada079f4243c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bm050971c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bm050971c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17600497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16529422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Fray, Miroslawa</creatorcontrib><creatorcontrib>Prowans, Piotr</creatorcontrib><creatorcontrib>Puskas, Judit E</creatorcontrib><creatorcontrib>Altstädt, Volker</creatorcontrib><title>Biocompatibility and Fatigue Properties of Polystyrene−Polyisobutylene−Polystyrene, an Emerging Thermoplastic Elastomeric Biomaterial</title><title>Biomacromolecules</title><addtitle>Biomacromolecules</addtitle><description>This paper will discuss the biocompatibility and dynamic fatigue properties of polystyrene-b-polyisobutylene-b-polystyrene thermoplastic elastomer with 30 wt % polystyrene (SIBS30), an emerging FDA-approved biomaterial. SIBS30 is a very soft, transparent biomaterial resembling silicone rubber, with superior mechanical properties. Using the hysteresis method adopted for soft biomaterials, the dynamic fatigue properties of SIBS30 were found to be between those of polyurethane and silicone rubber, with fatigue life twice as long as that of silicone. Under single load testing (SLT, 1.25 MPa), SIBS30 displayed less than half the dynamic creep compared to silicone, both in air and in vitro (37 °C, simulated body fluid). Hemolysis and 30- and 180-day implantation studies revealed excellent biocompatibility of the new biomaterial. The results presented in this paper indicate that, in comparison with silicone rubber, SIBS30 has similar biocompatibility and superior dynamic fatigue properties.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biological properties</subject><subject>Elasticity</subject><subject>Exact sciences and technology</subject><subject>Hemolysis</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Materials Testing - instrumentation</subject><subject>Medical sciences</subject><subject>Models, Chemical</subject><subject>Models, Molecular</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>Properties and characterization</subject><subject>Sheep</subject><subject>Silicones - chemistry</subject><subject>Styrenes - chemistry</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Tensile Strength</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9O3DAQxi1UxJ-FQ1-gyqWVkBqwYzuuj3S1UCQkOCznaOI4WyMnTm3nkDegVx6RJ8HLRt1LJUvzjeenbzQfQp8JviS4IFd1hzmWgqgDdEJ4UeasxMWnD81zIaQ4RqchPGOMJWX8CB2TkheSFcUJ-vvTOOW6AaKpjTVxyqBvspvUbkadPXo3aB-NDplrs0dnpxAnr3v99vK67Uxw9Rgnu_-Z59-TTbbqtN-YfpOtf2vfucFCiEZlq211aZZ02t5BTBLsGTpswQZ9PtcFerpZrZe_8vuH27vl9X0OlNGYS8UaXlAFmJTpIAAQumxa-AE6PUJk03JNlWolB0oYY7WEBrCQLSsYVZwu0Led7-Ddn1GHWHUmKG0t9NqNoSqFoCUvSQIvdqDyLgSv22rwpgM_VQRX29yrf7kn9stsOtadbvbkHHQCvs4ABAW29dArE_acSMcwKfYcqFA9u9H3KYv_LHwH0UGc7Q</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>El Fray, Miroslawa</creator><creator>Prowans, Piotr</creator><creator>Puskas, Judit E</creator><creator>Altstädt, Volker</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Biocompatibility and Fatigue Properties of Polystyrene−Polyisobutylene−Polystyrene, an Emerging Thermoplastic Elastomeric Biomaterial</title><author>El Fray, Miroslawa ; Prowans, Piotr ; Puskas, Judit E ; Altstädt, Volker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a343t-9c4d523ca016000aaa7e6dfa8ae8ae119df5e3ccf95a31444b9ada079f4243c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Applied sciences</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biological and medical sciences</topic><topic>Biological properties</topic><topic>Elasticity</topic><topic>Exact sciences and technology</topic><topic>Hemolysis</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Materials Testing - instrumentation</topic><topic>Medical sciences</topic><topic>Models, Chemical</topic><topic>Models, Molecular</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><topic>Properties and characterization</topic><topic>Sheep</topic><topic>Silicones - chemistry</topic><topic>Styrenes - chemistry</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Fray, Miroslawa</creatorcontrib><creatorcontrib>Prowans, Piotr</creatorcontrib><creatorcontrib>Puskas, Judit E</creatorcontrib><creatorcontrib>Altstädt, Volker</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomacromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Fray, Miroslawa</au><au>Prowans, Piotr</au><au>Puskas, Judit E</au><au>Altstädt, Volker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatibility and Fatigue Properties of Polystyrene−Polyisobutylene−Polystyrene, an Emerging Thermoplastic Elastomeric Biomaterial</atitle><jtitle>Biomacromolecules</jtitle><addtitle>Biomacromolecules</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>7</volume><issue>3</issue><spage>844</spage><epage>850</epage><pages>844-850</pages><issn>1525-7797</issn><eissn>1526-4602</eissn><abstract>This paper will discuss the biocompatibility and dynamic fatigue properties of polystyrene-b-polyisobutylene-b-polystyrene thermoplastic elastomer with 30 wt % polystyrene (SIBS30), an emerging FDA-approved biomaterial. SIBS30 is a very soft, transparent biomaterial resembling silicone rubber, with superior mechanical properties. Using the hysteresis method adopted for soft biomaterials, the dynamic fatigue properties of SIBS30 were found to be between those of polyurethane and silicone rubber, with fatigue life twice as long as that of silicone. Under single load testing (SLT, 1.25 MPa), SIBS30 displayed less than half the dynamic creep compared to silicone, both in air and in vitro (37 °C, simulated body fluid). Hemolysis and 30- and 180-day implantation studies revealed excellent biocompatibility of the new biomaterial. The results presented in this paper indicate that, in comparison with silicone rubber, SIBS30 has similar biocompatibility and superior dynamic fatigue properties.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>16529422</pmid><doi>10.1021/bm050971c</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Applied sciences Biocompatible Materials - chemistry Biological and medical sciences Biological properties Elasticity Exact sciences and technology Hemolysis Hot Temperature Humans Materials Testing - instrumentation Medical sciences Models, Chemical Models, Molecular Organic polymers Physicochemistry of polymers Properties and characterization Sheep Silicones - chemistry Styrenes - chemistry Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tensile Strength |
| title | Biocompatibility and Fatigue Properties of Polystyrene−Polyisobutylene−Polystyrene, an Emerging Thermoplastic Elastomeric Biomaterial |
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