Oncogenic osteomalacia: localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy
To highlight a strategy for potential detection of mesenchymal tumors in oncogenic malacia, as illustrated by 3 cases. Three case reports are presented in which successful localization of the offending neoplasm was accomplished by using whole-body Tc 99m sestamibi scanning. Alternative localization...
Gespeichert in:
| Veröffentlicht in: | Endocrine practice 2006-01, Vol.12 (1), p.35-42 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 42 |
|---|---|
| container_issue | 1 |
| container_start_page | 35 |
| container_title | Endocrine practice |
| container_volume | 12 |
| creator | Hodgson, Stephen F Clarke, Bart L Tebben, Peter J Mullan, Brian P Cooney, 3rd, William P Shives, Thomas C |
| description | To highlight a strategy for potential detection of mesenchymal tumors in oncogenic malacia, as illustrated by 3 cases.
Three case reports are presented in which successful localization of the offending neoplasm was accomplished by using whole-body Tc 99m sestamibi scanning. Alternative localization techniques are also reviewed.
Oncogenic osteomalacia occurs infrequently and is caused by neoplasms that secrete phosphatonins, substances that interfere with proximal tubular resorption of phosphorus and can result in phosphaturia, hypophosphatemia, reduced 1,25-dihydroxyvitamin D concentration, and osteomalacia. Removal of the underlying neoplasm results in complete resolution of all biochemical, pathologic, and physical manifestations of this disorder, as shown in our 3 patients. Because the neoplasms are small and can occur in any tissue compartment, they are difficult to localize, a feature that often results in therapeutic failure.
We conclude that use of whole-body Tc 99m sestamibi scanning may be an appropriate and cost-effective initial strategy for the localization of peripheral phosphatonin-secreting tumors. |
| doi_str_mv | 10.4158/EP.12.1.35 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67736512</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1709169002</sourcerecordid><originalsourceid>FETCH-LOGICAL-c261t-b40cbf7331ba8d90628d7f06d71f81e68cce61bc0517fca60952ef64b6bb58303</originalsourceid><addsrcrecordid>eNp90U9rFDEUAPAgiq2tFz-ABAQRYbZ5ySSTeJOyWqHQHip4C0kms5syk4zJDLL99KZ0QfDQ03uH33u8Pwi9A7JpgcuL7e0G6AY2jL9Ap6BY29CWsJc154w0UsGvE_SmlHtCKFEgX6MTEJy2UsAperiJLu18DA6nsvg0mdG4YL7gMTkzhgezhBRxGvAae5_HQ4g7PPsc5r3PZsSTLz66_aGW4WWdUi74T1j2eC3-sejOYaUmXHxZzBRswMWFuIRdNvP-cI5eDWYs_u0xnqGf37Z3l1fN9c33H5dfrxtHBSyNbYmzQ8cYWCN7RQSVfTcQ0XcwSPBCOucFWEc4dIMzgihO_SBaK6zlkhF2hj4-9Z1z-r3WUfQUivPjaKJPa9Gi65jgQCv89CyErp5PqHrGSj_8R-_TmmNdQ1fREaBtq6r6_KRcTqVkP-g5h8nkgwaiH1-nt7caqAbNeMXvjy1XO_n-Hz3-iv0FGieVCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1697012449</pqid></control><display><type>article</type><title>Oncogenic osteomalacia: localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy</title><source>MEDLINE</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Hodgson, Stephen F ; Clarke, Bart L ; Tebben, Peter J ; Mullan, Brian P ; Cooney, 3rd, William P ; Shives, Thomas C</creator><creatorcontrib>Hodgson, Stephen F ; Clarke, Bart L ; Tebben, Peter J ; Mullan, Brian P ; Cooney, 3rd, William P ; Shives, Thomas C</creatorcontrib><description>To highlight a strategy for potential detection of mesenchymal tumors in oncogenic malacia, as illustrated by 3 cases.
Three case reports are presented in which successful localization of the offending neoplasm was accomplished by using whole-body Tc 99m sestamibi scanning. Alternative localization techniques are also reviewed.
Oncogenic osteomalacia occurs infrequently and is caused by neoplasms that secrete phosphatonins, substances that interfere with proximal tubular resorption of phosphorus and can result in phosphaturia, hypophosphatemia, reduced 1,25-dihydroxyvitamin D concentration, and osteomalacia. Removal of the underlying neoplasm results in complete resolution of all biochemical, pathologic, and physical manifestations of this disorder, as shown in our 3 patients. Because the neoplasms are small and can occur in any tissue compartment, they are difficult to localize, a feature that often results in therapeutic failure.
We conclude that use of whole-body Tc 99m sestamibi scanning may be an appropriate and cost-effective initial strategy for the localization of peripheral phosphatonin-secreting tumors.</description><identifier>ISSN: 1530-891X</identifier><identifier>EISSN: 1934-2403</identifier><identifier>DOI: 10.4158/EP.12.1.35</identifier><identifier>PMID: 16524861</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Aged ; Bone Neoplasms - complications ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - pathology ; Bone Neoplasms - surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Mesoderm - pathology ; Middle Aged ; Neoplasms, Adipose Tissue - complications ; Neoplasms, Adipose Tissue - diagnostic imaging ; Neoplasms, Adipose Tissue - pathology ; Neoplasms, Adipose Tissue - surgery ; Neoplasms, Connective Tissue - complications ; Neoplasms, Connective Tissue - diagnostic imaging ; Neoplasms, Connective Tissue - pathology ; Neoplasms, Connective Tissue - surgery ; Osteomalacia - diagnostic imaging ; Osteomalacia - etiology ; Osteomalacia - pathology ; Radionuclide Imaging ; Risk Assessment ; Sampling Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Technetium Tc 99m Sestamibi</subject><ispartof>Endocrine practice, 2006-01, Vol.12 (1), p.35-42</ispartof><rights>Copyright Allen Press Publishing Services Jan/Feb 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c261t-b40cbf7331ba8d90628d7f06d71f81e68cce61bc0517fca60952ef64b6bb58303</citedby><cites>FETCH-LOGICAL-c261t-b40cbf7331ba8d90628d7f06d71f81e68cce61bc0517fca60952ef64b6bb58303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1697012449?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16524861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hodgson, Stephen F</creatorcontrib><creatorcontrib>Clarke, Bart L</creatorcontrib><creatorcontrib>Tebben, Peter J</creatorcontrib><creatorcontrib>Mullan, Brian P</creatorcontrib><creatorcontrib>Cooney, 3rd, William P</creatorcontrib><creatorcontrib>Shives, Thomas C</creatorcontrib><title>Oncogenic osteomalacia: localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy</title><title>Endocrine practice</title><addtitle>Endocr Pract</addtitle><description>To highlight a strategy for potential detection of mesenchymal tumors in oncogenic malacia, as illustrated by 3 cases.
Three case reports are presented in which successful localization of the offending neoplasm was accomplished by using whole-body Tc 99m sestamibi scanning. Alternative localization techniques are also reviewed.
Oncogenic osteomalacia occurs infrequently and is caused by neoplasms that secrete phosphatonins, substances that interfere with proximal tubular resorption of phosphorus and can result in phosphaturia, hypophosphatemia, reduced 1,25-dihydroxyvitamin D concentration, and osteomalacia. Removal of the underlying neoplasm results in complete resolution of all biochemical, pathologic, and physical manifestations of this disorder, as shown in our 3 patients. Because the neoplasms are small and can occur in any tissue compartment, they are difficult to localize, a feature that often results in therapeutic failure.
We conclude that use of whole-body Tc 99m sestamibi scanning may be an appropriate and cost-effective initial strategy for the localization of peripheral phosphatonin-secreting tumors.</description><subject>Aged</subject><subject>Bone Neoplasms - complications</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Mesoderm - pathology</subject><subject>Middle Aged</subject><subject>Neoplasms, Adipose Tissue - complications</subject><subject>Neoplasms, Adipose Tissue - diagnostic imaging</subject><subject>Neoplasms, Adipose Tissue - pathology</subject><subject>Neoplasms, Adipose Tissue - surgery</subject><subject>Neoplasms, Connective Tissue - complications</subject><subject>Neoplasms, Connective Tissue - diagnostic imaging</subject><subject>Neoplasms, Connective Tissue - pathology</subject><subject>Neoplasms, Connective Tissue - surgery</subject><subject>Osteomalacia - diagnostic imaging</subject><subject>Osteomalacia - etiology</subject><subject>Osteomalacia - pathology</subject><subject>Radionuclide Imaging</subject><subject>Risk Assessment</subject><subject>Sampling Studies</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Technetium Tc 99m Sestamibi</subject><issn>1530-891X</issn><issn>1934-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90U9rFDEUAPAgiq2tFz-ABAQRYbZ5ySSTeJOyWqHQHip4C0kms5syk4zJDLL99KZ0QfDQ03uH33u8Pwi9A7JpgcuL7e0G6AY2jL9Ap6BY29CWsJc154w0UsGvE_SmlHtCKFEgX6MTEJy2UsAperiJLu18DA6nsvg0mdG4YL7gMTkzhgezhBRxGvAae5_HQ4g7PPsc5r3PZsSTLz66_aGW4WWdUi74T1j2eC3-sejOYaUmXHxZzBRswMWFuIRdNvP-cI5eDWYs_u0xnqGf37Z3l1fN9c33H5dfrxtHBSyNbYmzQ8cYWCN7RQSVfTcQ0XcwSPBCOucFWEc4dIMzgihO_SBaK6zlkhF2hj4-9Z1z-r3WUfQUivPjaKJPa9Gi65jgQCv89CyErp5PqHrGSj_8R-_TmmNdQ1fREaBtq6r6_KRcTqVkP-g5h8nkgwaiH1-nt7caqAbNeMXvjy1XO_n-Hz3-iv0FGieVCw</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Hodgson, Stephen F</creator><creator>Clarke, Bart L</creator><creator>Tebben, Peter J</creator><creator>Mullan, Brian P</creator><creator>Cooney, 3rd, William P</creator><creator>Shives, Thomas C</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Oncogenic osteomalacia: localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy</title><author>Hodgson, Stephen F ; Clarke, Bart L ; Tebben, Peter J ; Mullan, Brian P ; Cooney, 3rd, William P ; Shives, Thomas C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c261t-b40cbf7331ba8d90628d7f06d71f81e68cce61bc0517fca60952ef64b6bb58303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Bone Neoplasms - complications</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Mesoderm - pathology</topic><topic>Middle Aged</topic><topic>Neoplasms, Adipose Tissue - complications</topic><topic>Neoplasms, Adipose Tissue - diagnostic imaging</topic><topic>Neoplasms, Adipose Tissue - pathology</topic><topic>Neoplasms, Adipose Tissue - surgery</topic><topic>Neoplasms, Connective Tissue - complications</topic><topic>Neoplasms, Connective Tissue - diagnostic imaging</topic><topic>Neoplasms, Connective Tissue - pathology</topic><topic>Neoplasms, Connective Tissue - surgery</topic><topic>Osteomalacia - diagnostic imaging</topic><topic>Osteomalacia - etiology</topic><topic>Osteomalacia - pathology</topic><topic>Radionuclide Imaging</topic><topic>Risk Assessment</topic><topic>Sampling Studies</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Technetium Tc 99m Sestamibi</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hodgson, Stephen F</creatorcontrib><creatorcontrib>Clarke, Bart L</creatorcontrib><creatorcontrib>Tebben, Peter J</creatorcontrib><creatorcontrib>Mullan, Brian P</creatorcontrib><creatorcontrib>Cooney, 3rd, William P</creatorcontrib><creatorcontrib>Shives, Thomas C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hodgson, Stephen F</au><au>Clarke, Bart L</au><au>Tebben, Peter J</au><au>Mullan, Brian P</au><au>Cooney, 3rd, William P</au><au>Shives, Thomas C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oncogenic osteomalacia: localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy</atitle><jtitle>Endocrine practice</jtitle><addtitle>Endocr Pract</addtitle><date>2006-01</date><risdate>2006</risdate><volume>12</volume><issue>1</issue><spage>35</spage><epage>42</epage><pages>35-42</pages><issn>1530-891X</issn><eissn>1934-2403</eissn><abstract>To highlight a strategy for potential detection of mesenchymal tumors in oncogenic malacia, as illustrated by 3 cases.
Three case reports are presented in which successful localization of the offending neoplasm was accomplished by using whole-body Tc 99m sestamibi scanning. Alternative localization techniques are also reviewed.
Oncogenic osteomalacia occurs infrequently and is caused by neoplasms that secrete phosphatonins, substances that interfere with proximal tubular resorption of phosphorus and can result in phosphaturia, hypophosphatemia, reduced 1,25-dihydroxyvitamin D concentration, and osteomalacia. Removal of the underlying neoplasm results in complete resolution of all biochemical, pathologic, and physical manifestations of this disorder, as shown in our 3 patients. Because the neoplasms are small and can occur in any tissue compartment, they are difficult to localize, a feature that often results in therapeutic failure.
We conclude that use of whole-body Tc 99m sestamibi scanning may be an appropriate and cost-effective initial strategy for the localization of peripheral phosphatonin-secreting tumors.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>16524861</pmid><doi>10.4158/EP.12.1.35</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-891X |
| ispartof | Endocrine practice, 2006-01, Vol.12 (1), p.35-42 |
| issn | 1530-891X 1934-2403 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67736512 |
| source | MEDLINE; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Aged Bone Neoplasms - complications Bone Neoplasms - diagnostic imaging Bone Neoplasms - pathology Bone Neoplasms - surgery Female Follow-Up Studies Humans Male Mesoderm - pathology Middle Aged Neoplasms, Adipose Tissue - complications Neoplasms, Adipose Tissue - diagnostic imaging Neoplasms, Adipose Tissue - pathology Neoplasms, Adipose Tissue - surgery Neoplasms, Connective Tissue - complications Neoplasms, Connective Tissue - diagnostic imaging Neoplasms, Connective Tissue - pathology Neoplasms, Connective Tissue - surgery Osteomalacia - diagnostic imaging Osteomalacia - etiology Osteomalacia - pathology Radionuclide Imaging Risk Assessment Sampling Studies Sensitivity and Specificity Severity of Illness Index Technetium Tc 99m Sestamibi |
| title | Oncogenic osteomalacia: localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T07%3A49%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oncogenic%20osteomalacia:%20localization%20of%20underlying%20peripheral%20mesenchymal%20tumors%20with%20use%20of%20Tc%2099m%20sestamibi%20scintigraphy&rft.jtitle=Endocrine%20practice&rft.au=Hodgson,%20Stephen%20F&rft.date=2006-01&rft.volume=12&rft.issue=1&rft.spage=35&rft.epage=42&rft.pages=35-42&rft.issn=1530-891X&rft.eissn=1934-2403&rft_id=info:doi/10.4158/EP.12.1.35&rft_dat=%3Cproquest_cross%3E1709169002%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1697012449&rft_id=info:pmid/16524861&rfr_iscdi=true |