Quality of life in elderly men with androgen deficiency
Summary The partial androgen deficiency in aging male (PADAM) has been of great interest to investigators and the public in the last few years. For males, androgens are said to be essential for the maintenance of quality of life (QoL) but there are no data available with respect to QoL and PADAM yet...
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| Veröffentlicht in: | Andrologia 2006-04, Vol.38 (2), p.48-53 |
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| creator | Finas, D. Bals-Pratsch, M. Sandmann, J. Eichenauer, R. Jocham, D. Diedrich, K. Schmucker, P. Hüppe, M. |
| description | Summary
The partial androgen deficiency in aging male (PADAM) has been of great interest to investigators and the public in the last few years. For males, androgens are said to be essential for the maintenance of quality of life (QoL) but there are no data available with respect to QoL and PADAM yet. In order to evaluate changes of individual well‐being of males older than 50 years and with subnormal levels of free testosterone (FT) ( |
| doi_str_mv | 10.1111/j.1439-0272.2006.00684.x |
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The partial androgen deficiency in aging male (PADAM) has been of great interest to investigators and the public in the last few years. For males, androgens are said to be essential for the maintenance of quality of life (QoL) but there are no data available with respect to QoL and PADAM yet. In order to evaluate changes of individual well‐being of males older than 50 years and with subnormal levels of free testosterone (FT) (<200 pmol l−1), these men were asked to fill in a questionnaire regarding QoL. The objective of this study was to compare age‐matched males with androgen deficiency (group 1; n = 24) and normoandrogenic elderly men (group 2; n = 24) with respect to QoL and somatic indicators of the endocrine status. Participants suffered from benign prostatic hyperplasia (BPH) and were hospitalized for prostate surgery. Health‐related QoL was assessed by the SF‐12 Health Survey, including the physical health index and the mental health index. The SF‐12 was enlarged by the scales ‘vitality’ and ‘psychological well‐being’ of the SF‐36. Additionally, patients were asked about social and clinical items. There were no statistically significant differences between the two groups regarding social and clinical parameters. The physical health index was reduced in group 1 (P < 0.05; effect size was medium (d = 0.57)) whereas the mental health index was similar in both groups. The correlation between the two health indices was very low and not statistically significant (r = 0.05, P = 0.72). Patients of group 1 described a lower vitality compared to group 2 (P < 0.05), but no differences could be observed regarding psychological well‐being. Therefore, androgen‐deficient patients seem to have the impression of a reduced physical ability. Our data emphasize that the subjective description of health‐related aspects of QoL is a very sensitive methodological approach to discover psychological differences between patients. For the differentiation between androgen‐deficient patients and those with normal testosterone levels the physical health index seems to be more sensitive than the mental health index. A question of interest is whether this difference remains detectable if testosterone is supplemented to androgen‐deficient men. Whether testosterone supplementation is beneficial to these patients has to be carefully considered.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/j.1439-0272.2006.00684.x</identifier><identifier>PMID: 16529575</identifier><identifier>CODEN: ANDRDQ</identifier><language>eng</language><publisher>Berlin, Germany: Blackwell Verlag GmbH</publisher><subject>Aged ; Androgens - deficiency ; Benign prostatic hyperplasia (BPH) ; Biological and medical sciences ; Case-Control Studies ; free testosterone ; Gynecology. Andrology. Obstetrics ; Hormones - blood ; Humans ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; PADAM ; Prostatic Hyperplasia - blood ; Quality of Life ; SF-12 Health Survey ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>Andrologia, 2006-04, Vol.38 (2), p.48-53</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4844-e271455c56712fa47cabddb9c6d6b5cdeccd2d1c259c2d22d1a0c9bb3e2d13d83</citedby><cites>FETCH-LOGICAL-c4844-e271455c56712fa47cabddb9c6d6b5cdeccd2d1c259c2d22d1a0c9bb3e2d13d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0272.2006.00684.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0272.2006.00684.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17590297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16529575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finas, D.</creatorcontrib><creatorcontrib>Bals-Pratsch, M.</creatorcontrib><creatorcontrib>Sandmann, J.</creatorcontrib><creatorcontrib>Eichenauer, R.</creatorcontrib><creatorcontrib>Jocham, D.</creatorcontrib><creatorcontrib>Diedrich, K.</creatorcontrib><creatorcontrib>Schmucker, P.</creatorcontrib><creatorcontrib>Hüppe, M.</creatorcontrib><title>Quality of life in elderly men with androgen deficiency</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
The partial androgen deficiency in aging male (PADAM) has been of great interest to investigators and the public in the last few years. For males, androgens are said to be essential for the maintenance of quality of life (QoL) but there are no data available with respect to QoL and PADAM yet. In order to evaluate changes of individual well‐being of males older than 50 years and with subnormal levels of free testosterone (FT) (<200 pmol l−1), these men were asked to fill in a questionnaire regarding QoL. The objective of this study was to compare age‐matched males with androgen deficiency (group 1; n = 24) and normoandrogenic elderly men (group 2; n = 24) with respect to QoL and somatic indicators of the endocrine status. Participants suffered from benign prostatic hyperplasia (BPH) and were hospitalized for prostate surgery. Health‐related QoL was assessed by the SF‐12 Health Survey, including the physical health index and the mental health index. The SF‐12 was enlarged by the scales ‘vitality’ and ‘psychological well‐being’ of the SF‐36. Additionally, patients were asked about social and clinical items. There were no statistically significant differences between the two groups regarding social and clinical parameters. The physical health index was reduced in group 1 (P < 0.05; effect size was medium (d = 0.57)) whereas the mental health index was similar in both groups. The correlation between the two health indices was very low and not statistically significant (r = 0.05, P = 0.72). Patients of group 1 described a lower vitality compared to group 2 (P < 0.05), but no differences could be observed regarding psychological well‐being. Therefore, androgen‐deficient patients seem to have the impression of a reduced physical ability. Our data emphasize that the subjective description of health‐related aspects of QoL is a very sensitive methodological approach to discover psychological differences between patients. For the differentiation between androgen‐deficient patients and those with normal testosterone levels the physical health index seems to be more sensitive than the mental health index. A question of interest is whether this difference remains detectable if testosterone is supplemented to androgen‐deficient men. Whether testosterone supplementation is beneficial to these patients has to be carefully considered.</description><subject>Aged</subject><subject>Androgens - deficiency</subject><subject>Benign prostatic hyperplasia (BPH)</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>free testosterone</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>PADAM</subject><subject>Prostatic Hyperplasia - blood</subject><subject>Quality of Life</subject><subject>SF-12 Health Survey</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtP3DAUha2qFYyAv4CyKbsEP-NY6gZNeVQaQZFALC3Hvmk99SRgz4jJv8dhRrDtlSwfy9-5vj4IFQRXJNf5siKcqRJTSSuKcV3l1fBq-wXNPi6-ohlmmJVc1OoQnaS0xLm4kJLzA3RIakGVkGKG5P3GBL8ei6Ergu-g8H0BwUEMY7GCvnj167-F6V0c_uSTg85bD70dj9G3zoQEJ_v9CD1eXT7Mb8rF3fWv-cWitLzhvAQqCRfCiloS2hkurWmda5WtXd0K68BaRx2xVChLHc3SYKvalkGWzDXsCJ3t-j7H4WUDaa1XPlkIwfQwbJKupWRc1TKDzQ60cUgpQqefo1-ZOGqC9ZSbXuopHj3Fo6fc9Htueputp_s3Nu0K3Kdxn1IGvu8Bk6wJXTS99emTk0JhqqYZfuy4Vx9g_O8B9MXtzyyyvdzZfVrD9sNu4r_8TSaFfrq91pw05GH--14v2BtcpZcF</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Finas, D.</creator><creator>Bals-Pratsch, M.</creator><creator>Sandmann, J.</creator><creator>Eichenauer, R.</creator><creator>Jocham, D.</creator><creator>Diedrich, K.</creator><creator>Schmucker, P.</creator><creator>Hüppe, M.</creator><general>Blackwell Verlag GmbH</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Quality of life in elderly men with androgen deficiency</title><author>Finas, D. ; Bals-Pratsch, M. ; Sandmann, J. ; Eichenauer, R. ; Jocham, D. ; Diedrich, K. ; Schmucker, P. ; Hüppe, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4844-e271455c56712fa47cabddb9c6d6b5cdeccd2d1c259c2d22d1a0c9bb3e2d13d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Androgens - deficiency</topic><topic>Benign prostatic hyperplasia (BPH)</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>free testosterone</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>PADAM</topic><topic>Prostatic Hyperplasia - blood</topic><topic>Quality of Life</topic><topic>SF-12 Health Survey</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finas, D.</creatorcontrib><creatorcontrib>Bals-Pratsch, M.</creatorcontrib><creatorcontrib>Sandmann, J.</creatorcontrib><creatorcontrib>Eichenauer, R.</creatorcontrib><creatorcontrib>Jocham, D.</creatorcontrib><creatorcontrib>Diedrich, K.</creatorcontrib><creatorcontrib>Schmucker, P.</creatorcontrib><creatorcontrib>Hüppe, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finas, D.</au><au>Bals-Pratsch, M.</au><au>Sandmann, J.</au><au>Eichenauer, R.</au><au>Jocham, D.</au><au>Diedrich, K.</au><au>Schmucker, P.</au><au>Hüppe, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life in elderly men with androgen deficiency</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2006-04</date><risdate>2006</risdate><volume>38</volume><issue>2</issue><spage>48</spage><epage>53</epage><pages>48-53</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><coden>ANDRDQ</coden><abstract>Summary
The partial androgen deficiency in aging male (PADAM) has been of great interest to investigators and the public in the last few years. For males, androgens are said to be essential for the maintenance of quality of life (QoL) but there are no data available with respect to QoL and PADAM yet. In order to evaluate changes of individual well‐being of males older than 50 years and with subnormal levels of free testosterone (FT) (<200 pmol l−1), these men were asked to fill in a questionnaire regarding QoL. The objective of this study was to compare age‐matched males with androgen deficiency (group 1; n = 24) and normoandrogenic elderly men (group 2; n = 24) with respect to QoL and somatic indicators of the endocrine status. Participants suffered from benign prostatic hyperplasia (BPH) and were hospitalized for prostate surgery. Health‐related QoL was assessed by the SF‐12 Health Survey, including the physical health index and the mental health index. The SF‐12 was enlarged by the scales ‘vitality’ and ‘psychological well‐being’ of the SF‐36. Additionally, patients were asked about social and clinical items. There were no statistically significant differences between the two groups regarding social and clinical parameters. The physical health index was reduced in group 1 (P < 0.05; effect size was medium (d = 0.57)) whereas the mental health index was similar in both groups. The correlation between the two health indices was very low and not statistically significant (r = 0.05, P = 0.72). Patients of group 1 described a lower vitality compared to group 2 (P < 0.05), but no differences could be observed regarding psychological well‐being. Therefore, androgen‐deficient patients seem to have the impression of a reduced physical ability. Our data emphasize that the subjective description of health‐related aspects of QoL is a very sensitive methodological approach to discover psychological differences between patients. For the differentiation between androgen‐deficient patients and those with normal testosterone levels the physical health index seems to be more sensitive than the mental health index. A question of interest is whether this difference remains detectable if testosterone is supplemented to androgen‐deficient men. Whether testosterone supplementation is beneficial to these patients has to be carefully considered.</abstract><cop>Berlin, Germany</cop><pub>Blackwell Verlag GmbH</pub><pmid>16529575</pmid><doi>10.1111/j.1439-0272.2006.00684.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Androgens - deficiency Benign prostatic hyperplasia (BPH) Biological and medical sciences Case-Control Studies free testosterone Gynecology. Andrology. Obstetrics Hormones - blood Humans Male Male genital diseases Medical sciences Middle Aged Nephrology. Urinary tract diseases PADAM Prostatic Hyperplasia - blood Quality of Life SF-12 Health Survey Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Quality of life in elderly men with androgen deficiency |
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