Neural basis of fear conditioning induced by video clip: Positron emission tomography study
In patients with post‐traumatic stress disorder (PTSD), re‐experiencing the trauma is often induced by external cues in the environment. The cues, which were emotionally neutral for the patients before the traumatic event, become fearful ones after the event. This phenomenon is considered to be asso...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2005-04, Vol.59 (2), p.155-162 |
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| creator | DORONBEKOV, TALANT K. TOKUNAGA, HIROMASA IKEJIRI, YOSHITAKA KAZUI, HIROAKI HATTA, NAOKI MASAKI, YOSHIHIRO OGINO, ATSUSHI MIYOSHI, NORIKO OKU, NAOHIKO NISHIKAWA, TAKASHI TAKEDA, MASATOSHI |
| description | In patients with post‐traumatic stress disorder (PTSD), re‐experiencing the trauma is often induced by external cues in the environment. The cues, which were emotionally neutral for the patients before the traumatic event, become fearful ones after the event. This phenomenon is considered to be associated with fear conditioning. The paradigm was set up so that the emotionality changes in the patients with PTSD would be reproduced, and the regional cerebral blood flow (rCBF) measured with positron emission tomography (PET) was compared during exposure to the same stimuli before and after acquisition of fear conditioning. Ten healthy male subjects were asked to look at some emotionally neutral photos, then to watch a video with fearful content that also contained images similar to that presented in the photos, and afterwards to look at the photos again. Five of the 10 subjects felt that the object in the photos was more fearful after watching the video than before, and they were considered to have acquired fear conditioning. In those five subjects, the rCBF in the right amygdala and the left posterior cingulate gyrus after acquisition of fear conditioning significantly increased relative to the rCBF before conditioning. Thus, these regions seem to have a critical role in fear conditioning. |
| doi_str_mv | 10.1111/j.1440-1819.2005.01351.x |
| format | Article |
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The cues, which were emotionally neutral for the patients before the traumatic event, become fearful ones after the event. This phenomenon is considered to be associated with fear conditioning. The paradigm was set up so that the emotionality changes in the patients with PTSD would be reproduced, and the regional cerebral blood flow (rCBF) measured with positron emission tomography (PET) was compared during exposure to the same stimuli before and after acquisition of fear conditioning. Ten healthy male subjects were asked to look at some emotionally neutral photos, then to watch a video with fearful content that also contained images similar to that presented in the photos, and afterwards to look at the photos again. Five of the 10 subjects felt that the object in the photos was more fearful after watching the video than before, and they were considered to have acquired fear conditioning. In those five subjects, the rCBF in the right amygdala and the left posterior cingulate gyrus after acquisition of fear conditioning significantly increased relative to the rCBF before conditioning. Thus, these regions seem to have a critical role in fear conditioning.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1111/j.1440-1819.2005.01351.x</identifier><identifier>PMID: 15823161</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Adult ; Adult and adolescent clinical studies ; amygdala ; Anxiety disorders. 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The cues, which were emotionally neutral for the patients before the traumatic event, become fearful ones after the event. This phenomenon is considered to be associated with fear conditioning. The paradigm was set up so that the emotionality changes in the patients with PTSD would be reproduced, and the regional cerebral blood flow (rCBF) measured with positron emission tomography (PET) was compared during exposure to the same stimuli before and after acquisition of fear conditioning. Ten healthy male subjects were asked to look at some emotionally neutral photos, then to watch a video with fearful content that also contained images similar to that presented in the photos, and afterwards to look at the photos again. Five of the 10 subjects felt that the object in the photos was more fearful after watching the video than before, and they were considered to have acquired fear conditioning. In those five subjects, the rCBF in the right amygdala and the left posterior cingulate gyrus after acquisition of fear conditioning significantly increased relative to the rCBF before conditioning. Thus, these regions seem to have a critical role in fear conditioning.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>amygdala</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Conditioning</subject><subject>Conditioning (Psychology) - physiology</subject><subject>Data Interpretation, Statistical</subject><subject>Emotions - physiology</subject><subject>Fear</subject><subject>Fear - physiology</subject><subject>fear conditioning</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Japan</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Positron emission tomography</subject><subject>Post-traumatic stress disorder</subject><subject>posterior cingulate gyrus</subject><subject>Posttraumatic stress disorder</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>PTSD</subject><subject>retrosplenial cortex</subject><subject>Stress Disorders, Post-Traumatic - diagnostic imaging</subject><subject>Stress Disorders, Post-Traumatic - physiopathology</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Videotape Recording</subject><subject>Videotapes</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkU9v1DAQxS0Eon_gKyBf4JbgsWM7RuKAVi1FqkoPcOJgOY5dvMrGi51A8-1x2FV7LHOZkf0b--k9hDCQGkq939bQNKSCFlRNCeE1Acahvn-GTh8unpeZUVYBA3GCznLeEkIYE_ASnQBvaTmGU_Tjxs3JDLgzOWQcPfbOJGzj2IcpxDGMdziM_Wxdj7sF_w69i9gOYf8B38YcphRH7HYh58LiKe7iXTL7nwvO09wvr9ALb4bsXh_7Ofp-efFtc1Vdf_38ZfPpurJcKai4BaeMtL1QouNUSJBEMN43bWONZ56qVhJrWudkS4F2BFTnPFAPjVCdB3aO3h3e3af4a3Z50kWRdcNgRhfnrIWUjLXkaZBLShpoRQHbA2hTzDk5r_cp7ExaNBC9JqC3ejVar0brNQH9LwF9X1bfHP-Yu53rHxePlhfg7REw2ZrBJzPakB85IZTkRBbu44H7Ewa3_LcAfbu5WSf2F1HwoSs</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>DORONBEKOV, TALANT K.</creator><creator>TOKUNAGA, HIROMASA</creator><creator>IKEJIRI, YOSHITAKA</creator><creator>KAZUI, HIROAKI</creator><creator>HATTA, NAOKI</creator><creator>MASAKI, YOSHIHIRO</creator><creator>OGINO, ATSUSHI</creator><creator>MIYOSHI, NORIKO</creator><creator>OKU, NAOHIKO</creator><creator>NISHIKAWA, TAKASHI</creator><creator>TAKEDA, MASATOSHI</creator><general>Blackwell Science Pty</general><general>Blackwell Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>Neural basis of fear conditioning induced by video clip: Positron emission tomography study</title><author>DORONBEKOV, TALANT K. ; TOKUNAGA, HIROMASA ; IKEJIRI, YOSHITAKA ; KAZUI, HIROAKI ; HATTA, NAOKI ; MASAKI, YOSHIHIRO ; OGINO, ATSUSHI ; MIYOSHI, NORIKO ; OKU, NAOHIKO ; NISHIKAWA, TAKASHI ; TAKEDA, MASATOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5991-5c1e9a7cd696b5267170635d484caf3f29870ca8ee78212b019bef12f1469bf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>amygdala</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Conditioning</topic><topic>Conditioning (Psychology) - physiology</topic><topic>Data Interpretation, Statistical</topic><topic>Emotions - physiology</topic><topic>Fear</topic><topic>Fear - physiology</topic><topic>fear conditioning</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Japan</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Positron emission tomography</topic><topic>Post-traumatic stress disorder</topic><topic>posterior cingulate gyrus</topic><topic>Posttraumatic stress disorder</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>PTSD</topic><topic>retrosplenial cortex</topic><topic>Stress Disorders, Post-Traumatic - diagnostic imaging</topic><topic>Stress Disorders, Post-Traumatic - physiopathology</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>Videotape Recording</topic><topic>Videotapes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DORONBEKOV, TALANT K.</creatorcontrib><creatorcontrib>TOKUNAGA, HIROMASA</creatorcontrib><creatorcontrib>IKEJIRI, YOSHITAKA</creatorcontrib><creatorcontrib>KAZUI, HIROAKI</creatorcontrib><creatorcontrib>HATTA, NAOKI</creatorcontrib><creatorcontrib>MASAKI, YOSHIHIRO</creatorcontrib><creatorcontrib>OGINO, ATSUSHI</creatorcontrib><creatorcontrib>MIYOSHI, NORIKO</creatorcontrib><creatorcontrib>OKU, NAOHIKO</creatorcontrib><creatorcontrib>NISHIKAWA, TAKASHI</creatorcontrib><creatorcontrib>TAKEDA, MASATOSHI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DORONBEKOV, TALANT K.</au><au>TOKUNAGA, HIROMASA</au><au>IKEJIRI, YOSHITAKA</au><au>KAZUI, HIROAKI</au><au>HATTA, NAOKI</au><au>MASAKI, YOSHIHIRO</au><au>OGINO, ATSUSHI</au><au>MIYOSHI, NORIKO</au><au>OKU, NAOHIKO</au><au>NISHIKAWA, TAKASHI</au><au>TAKEDA, MASATOSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural basis of fear conditioning induced by video clip: Positron emission tomography study</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2005-04</date><risdate>2005</risdate><volume>59</volume><issue>2</issue><spage>155</spage><epage>162</epage><pages>155-162</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>In patients with post‐traumatic stress disorder (PTSD), re‐experiencing the trauma is often induced by external cues in the environment. The cues, which were emotionally neutral for the patients before the traumatic event, become fearful ones after the event. This phenomenon is considered to be associated with fear conditioning. The paradigm was set up so that the emotionality changes in the patients with PTSD would be reproduced, and the regional cerebral blood flow (rCBF) measured with positron emission tomography (PET) was compared during exposure to the same stimuli before and after acquisition of fear conditioning. Ten healthy male subjects were asked to look at some emotionally neutral photos, then to watch a video with fearful content that also contained images similar to that presented in the photos, and afterwards to look at the photos again. Five of the 10 subjects felt that the object in the photos was more fearful after watching the video than before, and they were considered to have acquired fear conditioning. In those five subjects, the rCBF in the right amygdala and the left posterior cingulate gyrus after acquisition of fear conditioning significantly increased relative to the rCBF before conditioning. Thus, these regions seem to have a critical role in fear conditioning.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>15823161</pmid><doi>10.1111/j.1440-1819.2005.01351.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies amygdala Anxiety disorders. Neuroses Biological and medical sciences Conditioning Conditioning (Psychology) - physiology Data Interpretation, Statistical Emotions - physiology Fear Fear - physiology fear conditioning Humans Image Processing, Computer-Assisted Japan Male Medical sciences Positron emission tomography Post-traumatic stress disorder posterior cingulate gyrus Posttraumatic stress disorder Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry PTSD retrosplenial cortex Stress Disorders, Post-Traumatic - diagnostic imaging Stress Disorders, Post-Traumatic - physiopathology Stress Disorders, Post-Traumatic - psychology Videotape Recording Videotapes |
| title | Neural basis of fear conditioning induced by video clip: Positron emission tomography study |
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