Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach

Background & Aims: The epithelial zinc-finger transcription factor Klf4 (formerly GKLF) regulates cellular proliferation and differentiation in vitro. Klf4 null mice die by postnatal day 1 and show changes in epithelial differentiation of skin and colon. Methods: We used tissue-specific gene abl...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2005-04, Vol.128 (4), p.935-945
Hauptverfasser:	Katz, Jonathan P., Perreault, Nathalie, Goldstein, Bree G., Actman, Lori, McNally, Sara R., Silberg, Debra G., Furth, Emma E., Kaestner, Klaus H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CDX2 Transcription Factor Cell Cycle Proteins - metabolism Cell Differentiation Cell Proliferation Cyclin-Dependent Kinase Inhibitor p21 DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gastric Mucosa - pathology Homeodomain Proteins - metabolism Homeostasis Kruppel-Like Transcription Factors Mice Mutation Precancerous Conditions - genetics Precancerous Conditions - metabolism Precancerous Conditions - pathology Stomach - pathology Stomach Neoplasms - metabolism Tissue Distribution Transcription Factors - genetics Transcription Factors - metabolism Trefoil Factor-2
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